Coordination Chemistry Reviews, Год журнала: 2024, Номер 525, С. 216306 - 216306
Опубликована: Ноя. 22, 2024
Язык: Английский
Dalton Transactions, Год журнала: 2024, Номер 53(32), С. 13591 - 13601
Опубликована: Янв. 1, 2024
Here, we have synthesized and characterized three visible light responsive terpyridine based-Re(I)-tricarbonyl complexes; [Re(CO)
Язык: Английский
Процитировано
5
Molecules, Год журнала: 2025, Номер 30(4), С. 915 - 915
Опубликована: Фев. 16, 2025
The 'wire-like' acetylenic moiety is an important building block in organic and coordination chemistry that can facilitate electron transfer donor-acceptor compounds, contributing to the enhancement of their photophysical properties. 2,6-Bis-(thiazol-2-yl)pyridine (dtpy) functionalized with a 4-phenylacetylene group (Ph-C≡C-dtpy) was, for first time, used preparation [ReCl(CO)3(Ph-C≡C-dtpy)] [Pt(Ph-C≡C-dtpy)Cl]CF3SO3 order understand properties derived from use substituent. ability Ph-C≡C-dtpy toward Pt(II) Re(I) centers was determined. All studied compounds were characterized using FT-IR, 1H NMR, 13C NMR spectroscopies, elemental analysis and, case free ligand rhenium(I) complex, single-crystal X-ray also used. Their electrochemical, photophysical, thermal compared previously described similar systems. photoluminescence spectra Ph-C≡C-dtpy, investigated solution solid state at 298 K 77 K. experimental results supported by DFT TD-DFT calculations. As result introduction -C≡C- into skeleton, complexes display room-temperature emission. In [Pt(Ph-C≡C-dtpy)Cl]CF3SO3, lifetime microsecond regime observed, whereas nanosecond comparable lifetimes observed 4-substituted dtpys.
Язык: Английский
Процитировано
0
Inorganic Chemistry Communications, Год журнала: 2025, Номер 175, С. 114155 - 114155
Опубликована: Фев. 20, 2025
Язык: Английский
Процитировано
0
European Journal of Inorganic Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Фев. 18, 2025
Abstract Difficulties to abate the vehemence of deleterious triple‐negative breast cancer (TNBC) is an ardent issue in current context anticancer research due lack a selective treatment modality. To address this issue, herein we have endeavored establish imidazophenanthroline‐based Ir(III)‐cyclometallated heteroleptic complexes, suited for one‐photon photodynamic therapy (OP‐PDT) under irradiation visible light (400–700 nm) possessing long‐lived excited triplet state and significant photostability. Among three synthesized [ L1Ir ], L2Ir L3Ir complex ] has been recognized as most competent exhibit phototoxicity (IC 50 =3.8 μ M; PI c =78.94) MDA‐MB‐231 cells. The complexes arisen production reactive singlet oxygen ( 1 O 2 ) following type‐II pathway (Φ s =0.26). Also, shown proficiency oxidation reduced nicotinamide adenine dinucleotide (NADH) (TOF=4.35 h −1 indicating possibility species (O ⋅ − , ⋅OH) generation through type‐I upon irradiation. Along with this, intracellular glutathione (GSH) depletion capabilities endued unarm TNBC cells front profuse amount ROS instigating programmed cell death (PCD) substantial DNA damage.
Язык: Английский
Процитировано
0
Journal of the American Chemical Society, Год журнала: 2025, Номер 147(9), С. 7161 - 7181
Опубликована: Фев. 20, 2025
Photocatalytic cancer therapy (PCT) has emerged as a cutting-edge anticancer mechanism of action, harnessing light energy to mediate the catalytic oxidation intracellular substrates. PCT is significant current importance due its potential address limitations conventional chemotherapy, particularly drug resistance and side effects. This approach offers noninvasive, targeted treatment option by utilizing metal-based photocatalysts induce redox metabolic disorders within cells. The disrupt cell metabolism converting NADH/NAD(P)H NAD+/NAD(P)+ via photoredox processes, altering NAD+/NADH or NAD(P)+/NAD(P)H ratios, which are crucial for cellular metabolism. Ir(III), Ru(II), Re(I), Os(II) demonstrated promising efficacy. Despite these developments, gaps remain in literature translating this new into clinical trials. Perspective critically examines developments research area provides future directions designing efficient PCT.
Язык: Английский
Процитировано
0
Coordination Chemistry Reviews, Год журнала: 2025, Номер 537, С. 216689 - 216689
Опубликована: Апрель 13, 2025
Язык: Английский
Процитировано
0
Chemistry - An Asian Journal, Год журнала: 2025, Номер unknown
Опубликована: Апрель 14, 2025
Abstract Fluorine and nonfluorine substituted rhenium(I) metallocycles, fac ‐[{Re(CO) 3 } 2 ( μ ‐SO 4 )(L1) ] C1 ) )(L2) C2 ), respectively, were synthesized using Re (CO) 10 , sodium bisulfite, fluorobenzimidazolyl/benzimidazolyl‐based ditopic nitrogen‐donor ligands (L1/L2), toluene–acetone via coordination‐driven one‐pot solvothermal approach. The metallocycles characterized elemental analysis, ESI‐TOF‐MS, ATR‐IR, NMR, PXRD methods. molecular structures of ·9(DMSO), ·(toluene)(acetone), ·(toluene) determined SCXRD analysis. in vitro cytotoxicity study was performed against cervical (HeLa) skin (B16) cancer cells. Murine fibroblast (L929) mouse myoblast (C2C12) cells used as noncarcinogenic model cell lines for biocompatibility determination. exhibited potent anticancer activity both lines, showing greater efficacy than the commonly cisplatin. Moreover, fluorine‐substituted metallocycle significantly higher nonfluorinated metallocycle, indicating a fluorine effect. Further, in‐depth studies on HeLa showed elevated intracellular ROS generation, disruption mitochondrial membrane potential, antiproliferative properties. also revealed its ability to bind with DNA induce changes cellular morphology, thus leading damage death by apoptosis. Molecular docking B‐DNA macromolecule binding sites, affinity, type noncovalent interactions.
Язык: Английский
Процитировано
0
Medicinal Chemistry Research, Год журнала: 2025, Номер unknown
Опубликована: Апрель 16, 2025
Язык: Английский
Процитировано
0
Coordination Chemistry Reviews, Год журнала: 2024, Номер 525, С. 216306 - 216306
Опубликована: Ноя. 22, 2024
Язык: Английский
Процитировано
2