European Journal of Inorganic Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Фев. 18, 2025
Abstract Difficulties to abate the vehemence of deleterious triple‐negative breast cancer (TNBC) is an ardent issue in current context anticancer research due lack a selective treatment modality. To address this issue, herein we have endeavored establish imidazophenanthroline‐based Ir(III)‐cyclometallated heteroleptic complexes, suited for one‐photon photodynamic therapy (OP‐PDT) under irradiation visible light (400–700 nm) possessing long‐lived excited triplet state and significant photostability. Among three synthesized [ L1Ir ], L2Ir L3Ir complex ] has been recognized as most competent exhibit phototoxicity (IC 50 =3.8 μ M; PI c =78.94) MDA‐MB‐231 cells. The complexes arisen production reactive singlet oxygen ( 1 O 2 ) following type‐II pathway (Φ s =0.26). Also, shown proficiency oxidation reduced nicotinamide adenine dinucleotide (NADH) (TOF=4.35 h −1 indicating possibility species (O ⋅ − , ⋅OH) generation through type‐I upon irradiation. Along with this, intracellular glutathione (GSH) depletion capabilities endued unarm TNBC cells front profuse amount ROS instigating programmed cell death (PCD) substantial DNA damage.
Язык: Английский