Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 3, 2025
Abstract
Fabricating
hydrogel‐based
channels
with
diameters
below
200
µm
remains
challenging
in
advanced
vitro
modeling
and
tissue
engineering.
To
address
this
challenge,
thermoshrinkable
hydrogels
that
undergo
reversible
isotropic
dimensional
changes
temperature
are
developed.
A
thermoresponsive
polymer
methacrylate
groups
(PNH‐MA)
is
synthesized
from
polyethylene
glycol
(PEG),
N–isopropylacrylamide
(NIPAM),
2‐hydroxyethyl
acrylate
(HEA),
enabling
photo‐cross‐linking
precise
material
tuning.
PNH‐MA
can
shrink
up
to
90%
volume
(50%
diameter)
remain
transparent
allowing
cellular
imaging.
In
a
four‐dimension
(4D)
fabrication
strategy,
seeded
proximal
tubule
epithelial
cells
shrunk
reduce
diameters.
Using
pin
pull‐out
mold
casting,
of
120
410
65
µm,
respectively.
While
needle
injection
for
smaller
than
volumetric
printing
addresses
limitation.
The
shrinkage
properties
enable
leak‐proof
perfusion,
cell
seeding
continuous
unilateral
flow
as
small
100170
µm.
polymers
represent
one
the
few
examples
low‐viscosity
resins
successfully
used
hydrogel
complex
scaffolds.
This
study
highlights
potential
scalable,
high‐precision
tubular
scaffold
modeling.
Molecules,
Год журнала:
2025,
Номер
30(3), С. 686 - 686
Опубликована: Фев. 4, 2025
Chronic
wounds
pose
a
substantial
healthcare
concern
due
to
their
prevalence
and
cost
burden.
This
paper
presents
detailed
overview
of
chronic
emphasizes
the
critical
need
for
novel
therapeutic
solutions.
The
pathophysiology
wound
healing
is
discussed,
including
stages
factors
contributing
chronicity.
focus
on
diverse
types
wounds,
such
as
diabetic
foot
necrosis,
pressure
ulcers,
venous
leg
highlighting
etiology,
consequences,
issues
they
provide.
Further,
modern
care
solutions,
particularly
hydrogels,
are
highlighted
tackling
challenges
management.
Hydrogels
characterized
multipurpose
materials
that
possess
vital
characteristics
like
capacity
retain
moisture,
biocompatibility,
incorporation
active
drugs.
Hydrogels’
effectiveness
in
applications
demonstrated
by
how
support
healing,
preserving
ideal
moisture
levels,
promoting
cellular
migration,
possessing
antibacterial
properties.
Thus,
this
hydrogel
technology’s
latest
developments,
emphasizing
drug-loaded
stimuli-responsive
underscoring
these
advanced
formulations
greatly
improve
therapy
outcomes
enabling
dynamic
focused
reactions
environment.
Future
directions
research
promote
development
customized
treatments
digital
health
tools
treatment
wounds.
Recently,
researchers
have
been
exploring
the
use
of
dynamic
covalent
bonds
(DCBs)
in
construction
exchangeable
liquid
crystal
elastomers
(LCEs)
for
biomimetic
actuators
and
devices.
However,
a
significant
challenge
remains
achieving
LCEs
with
both
excellent
properties
superior
mechanical
strength
stability.
In
this
study,
diacrylate-functionalized
monomer
containing
hindered
urea
(DA-HUB)
is
employed
to
prepare
through
self-catalytic
Michael
addition
reaction.
By
incorporating
DA-HUB,
LCE
system
benefits
from
DCBs
hydrogen
bonding,
leading
materials
high
range
such
as
programmability,
self-healing,
recyclability.
Leveraging
these
characteristics,
bilayer
controlled
reversible
thermal
deformation
outstanding
dimensional
stability
are
successfully
fabricated
using
simple
welding
method.
Moreover,
triangular
plum,
inspired
by
blooming
flowers,
created
showcase
color
shape
changes
triggered
light
heat.
This
innovative
approach
opens
new
possibilities
development
smart
devices
multiple
functionalities.
Materials,
Год журнала:
2024,
Номер
17(17), С. 4255 - 4255
Опубликована: Авг. 28, 2024
Today,
smart
materials
are
commonly
used
in
various
fields
of
science
and
technology,
such
as
medicine,
electronics,
soft
robotics,
the
chemical
industry,
automotive
field,
many
others.
Smart
polymeric
hold
good
promise
for
future
due
to
their
endless
possibilities.
This
group
advanced
can
be
sensitive
changes
or
presence
chemical,
physical,
biological
stimuli,
e.g.,
light,
temperature,
pH,
magnetic/electric
pressure,
microorganisms,
bacteria,
viruses,
toxic
substances,
review
concerns
newest
achievements
area
materials.
The
recent
advances
designing
stimuli-responsive
polymers
described
this
paper.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 3, 2025
Abstract
Hydrogels,
which
mimic
the
properties
of
natural
tissues,
are
essential
for
flexible
electronics
in
human‐machine
interfaces
(HMIs).
However,
traditional
hydrogels
suffer
from
dehydration,
compromising
stability
and
functionality.
To
address
this
issue,
a
stratum
corneum‐inspired,
water‐retaining
hydrogel
is
developed
using
hygroscopic
polymers
bound
water.
Three
types
hydrophilic
monomers
(non‐ionic,
mono‐ionic,
zwitterionic)
explored,
with
polyzwitterions,
particularly
N,N‐dimethyl
(acrylamidopropyl)
ammonium
propane
sulfonate
(DMAAPS),
forming
quasi‐hydrogel
that
retains
softness
flexibility
conventional
hydrogels.
Water
acts
as
plasticizer,
enhancing
polymer
chain
mobility
reducing
stiffness.
The
DMAAPS
maintains
100%
weight
retention
under
specific
humidity
conditions
shows
skin‐like
across
wide
range.
Young's
modulus
increases
54
to
118
kPa
relative
decreases
80%
40%.
absence
free
water
confers
intrinsic
anti‐freezing
properties.
A
triple
crosslinking
mechanism
conductive
endow
stretchability
(>
2000%),
toughness,
elasticity,
self‐healing,
stable
sensing
capabilities.
functions
an
excellent
sensor
real‐time,
sensitive
detection
human
motion
physiological
signals.
An
intelligent
handwriting
recognition
platform
high
accuracy
also
established
double‐channel
signal
collection
machine
learning
algorithms,
offering
insights
next‐generation
durable,
biomimetic,
smart
HMIs.
Polymer Chemistry,
Год журнала:
2024,
Номер
15(27), С. 2719 - 2739
Опубликована: Янв. 1, 2024
This
paper
explores
the
innovative
realm
of
thermoresponsive
ionogels,
which
leverage
unique
properties
ionic
liquids,
such
as
high
conductivity,
robust
stability,
and
minimal
volatility.
Materials,
Год журнала:
2024,
Номер
17(19), С. 4792 - 4792
Опубликована: Сен. 29, 2024
Hydrogels,
known
for
their
unique
ability
to
retain
large
amounts
of
water,
have
emerged
as
pivotal
materials
in
both
tissue
engineering
and
biosensing
applications.
This
review
provides
an
updated
comprehensive
examination
cutting-edge
hydrogel
technologies
multifaceted
roles
these
fields.
Initially,
the
chemical
composition
intrinsic
properties
natural
synthetic
hydrogels
are
discussed,
highlighting
biocompatibility
biodegradability.
The
manuscript
then
probes
into
innovative
scaffold
designs
fabrication
techniques
such
3D
printing,
electrospinning,
self-assembly
methods,
emphasizing
applications
regenerating
bone,
cartilage,
skin,
neural
tissues.
In
realm
biosensing,
hydrogels’
responsive
nature
is
explored
through
integration
optical,
electrochemical,
piezoelectric
sensors.
These
sensors
instrumental
medical
diagnostics
glucose
monitoring,
pathogen
detection,
biomarker
identification,
well
environmental
industrial
like
pollution
food
quality
monitoring.
Furthermore,
explores
cross-disciplinary
innovations,
including
use
wearable
devices,
hybrid
systems,
potential
personalized
medicine.
By
addressing
current
challenges
future
directions,
this
aims
underscore
transformative
impact
advancing
healthcare
practices,
thereby
providing
a
vital
resource
researchers
practitioners
field.
Polymer Reviews,
Год журнала:
2024,
Номер
unknown, С. 1 - 65
Опубликована: Ноя. 20, 2024
The
biomedical
industry
has
witnessed
a
transformative
evolution
with
the
advent
of
3D
printing
technology.
However,
inherent
limitations,
such
as
inability
to
produce
dynamic
human
tissues
due
absence
temporal
dimension,
have
persisted,
resulting
in
static
and
inanimate
printed
products.
To
address
this
challenge
enable
creation
living
constructs,
concept
4D
emerged,
marking
paradigm
shift
additive
manufacturing.
In
printing,
time
becomes
fourth
breathing
life
into
previously
creations.
This
review
paper
explores
journey
from
pivotal
role
manufacturing
process.
Specifically,
it
highlights
integration
time-dependent
responsive
materials,
focusing
on
stimuli-responsive
hydrogels,
cornerstone
advancements.
These
materials
exhibit
remarkable
ability
adapt
respond
various
stimuli,
encompassing
physical,
chemical,
biological
signals.
delves
recent
publications
synergy
between
these
stimuli
shedding
light
their
intricate
interactions
potential
applications.
One
primary
areas
interest
lies
medical
applications,
notably
tissue
engineering,
where
holds
immense
promise.
utilization
creating
biomimetic
scaffolds
that
can
dynamically
complex
environments.
Furthermore,
discusses
technical
considerations
prospects
technology,
emphasizing
its
revolutionize
landscape.
amalgamation
opens
new
avenues
for
personalized
medicine,
localized
drug
delivery,
regenerative
therapies,
bridging
gap
requirements
modern
healthcare.
present
offers
complete
examination
evolution,
challenges,
paving
way
innovations
field.
Gels,
Год журнала:
2024,
Номер
10(2), С. 122 - 122
Опубликована: Фев. 2, 2024
Gels
are
attracting
materials
for
energy
storage
technologies.
The
strategic
development
of
hydrogels
with
enhanced
physicochemical
properties,
such
as
superior
mechanical
strength,
flexibility,
and
charge
transport
capabilities,
introduces
novel
prospects
advancing
next-generation
batteries,
fuel
cells,
supercapacitors.
Through
a
refined
comprehension
gelation
chemistry,
researchers
have
achieved
notable
progress
in
fabricating
endowed
stimuli-responsive,
self-healing,
highly
stretchable
characteristics.
This
mini-review
delineates
the
integration
into
supercapacitors,
showcasing
compelling
instances
that
underscore
versatility
hydrogels,
including
tailorable
architectures,
conductive
nanostructures,
3D
frameworks,
multifunctionalities.
ongoing
application
creative
combinatorial
approaches
functional
hydrogel
design
is
poised
to
yield
immense
potential
within
domain
storage.
