Exploring the Chemistry and Applications of Thio-, Seleno-, and Tellurosugars DOI Creative Commons
Roxana Martínez-Pascual, M. Valera‐Zaragoza, José G. Fernández‐Bolaños

и другие.

Molecules, Год журнала: 2025, Номер 30(9), С. 2053 - 2053

Опубликована: Май 5, 2025

Given the crucial roles of carbohydrates in energy supply, biochemical processes, signaling events and pathogenesis several diseases, development carbohydrate analogues, called glycomimetics, is a key research area Glycobiology, Pharmacology, Medicinal Chemistry. Among many structural transformations explored, replacement endo- exocyclic oxygen atoms by carbon (carbasugars) or heteroatoms, such as nitrogen (aza- iminosugars), phosphorous (phosphasugars), sulfur (thiosugars), selenium (selenosugars) tellurium (tellurosugars) have garnered significant attention. These isosteric substitutions can modulate bioavailability, stability, bioactivity, while introducing new properties, redox activity, interactions with pathological lectins enzymes, cytotoxic effects. In this manuscript we focused on three major families glycomimetics: thio-, seleno-, tellurosugars. We provide comprehensive review most relevant synthetic pathways leading to primarily at endocyclic glycosidic positions. The scope includes metal-catalyzed reactions, organocatalysis, electro- photochemical transformations, free-radical automated syntheses. Additionally, mechanistic insights, stereoselectivity, biological properties are also discussed. diversity promising bioactivities these glycomimetics underscore their significance area.

Язык: Английский

Exploring the Chemistry and Applications of Thio-, Seleno-, and Tellurosugars DOI Creative Commons
Roxana Martínez-Pascual, M. Valera‐Zaragoza, José G. Fernández‐Bolaños

и другие.

Molecules, Год журнала: 2025, Номер 30(9), С. 2053 - 2053

Опубликована: Май 5, 2025

Given the crucial roles of carbohydrates in energy supply, biochemical processes, signaling events and pathogenesis several diseases, development carbohydrate analogues, called glycomimetics, is a key research area Glycobiology, Pharmacology, Medicinal Chemistry. Among many structural transformations explored, replacement endo- exocyclic oxygen atoms by carbon (carbasugars) or heteroatoms, such as nitrogen (aza- iminosugars), phosphorous (phosphasugars), sulfur (thiosugars), selenium (selenosugars) tellurium (tellurosugars) have garnered significant attention. These isosteric substitutions can modulate bioavailability, stability, bioactivity, while introducing new properties, redox activity, interactions with pathological lectins enzymes, cytotoxic effects. In this manuscript we focused on three major families glycomimetics: thio-, seleno-, tellurosugars. We provide comprehensive review most relevant synthetic pathways leading to primarily at endocyclic glycosidic positions. The scope includes metal-catalyzed reactions, organocatalysis, electro- photochemical transformations, free-radical automated syntheses. Additionally, mechanistic insights, stereoselectivity, biological properties are also discussed. diversity promising bioactivities these glycomimetics underscore their significance area.

Язык: Английский

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