Efficient Cytosolic Delivery of Single-Chain Polymeric Artificial Enzymes for Intracellular Catalysis and Chemo-Dynamic Therapy DOI
Di Zheng, Jing Tao, Liping Jiang

и другие.

Journal of the American Chemical Society, Год журнала: 2024, Номер 147(1), С. 998 - 1007

Опубликована: Дек. 30, 2024

Designing artificial enzymes for in vivo catalysis presents a great challenge due to biomacromolecule contamination, poor biodistribution, and insufficient substrate interaction. Herein, we developed single-chain polymeric nanoparticles with Cu/N-heterocyclic carbene active sites (SCNP-Cu) function as peroxidase mimics chemo-dynamic therapy (CDT). Compared the enzyme based on unfolded linear polymer scaffold multichain cross-linked scaffold, SCNP-Cu exhibits improved tumor accumulation CDT efficiency both vitro vivo. Protein-like size of SCNP promotes passive diffusion, whereas positive surface charge allows its transcytosis deep penetration hence site. The submolecular compartments effectively protect from protein bindings, thereby providing "cleaner" microenvironment within living system. folded structure facilitates their cytosolic delivery free diffusion cytosol, ensuring efficient contact endogenous H2O2, situ generation toxic hydroxyl radicals (·OH), effective damage intracellular targets (i.e., lipids, nucleic acids). This work establishes versatile SCNP-based nanoplatforms developing catalysis.

Язык: Английский

Cyclized/Knotted Polydivinylbenzene (Pdvb) Antibacterial Coatings DOI
J. F. Sun,

Long Huang,

Yi Cai

и другие.

Опубликована: Янв. 1, 2025

In the medical industry, minimizing biofouling is of utmost importance as it helps to reduce bacterial adhesion and prevent cross-infection. this study, cyclized/knotted polydivinylbenzene (PDVB), a polymer with distinctive structural features, proposed for first time be utilized in preparation antibacterial coatings. Firstly, (PDVB) synthesized via deactivation-enhanced atom transfer radical polymerization (DE-ATRP). Subsequently, processed into coatings by employing "grafting to" method. The obtained PDVB display remarkable activity on both glass titanium alloy substrates owing their unique structure, effectively inhibiting proliferation common pathogenic bacteria. Additionally, also exhibit excellent hydrophobicity, strong adhesion, superior thermal stability. These research findings suggest that possess outstanding physicochemical properties demonstrate powerful performance. It anticipated open up new avenues materials.

Язык: Английский

Процитировано

0
Cyclized/knotted Polydivinylbenzene (PDVB) antibacterial coatings DOI
J. F. Sun,

Long Huang,

Yi Cai

и другие.

Progress in Organic Coatings, Год журнала: 2025, Номер 205, С. 109304 - 109304

Опубликована: Апрель 10, 2025

Язык: Английский

Процитировано

0
Biobased Cyclic Polycarbonate: Synthesis and Applications via Dynamic Bis(hindered amino)disulfide Linkers DOI
Hirogi Yokochi, Takumi Abe,

Shunsuke Fujimata

и другие.

ACS Macro Letters, Год журнала: 2025, Номер unknown, С. 750 - 756

Опубликована: Май 17, 2025

Cyclic polymers have garnered significant interest due to their unique structure; however, synthesis remains challenging, often hindered by low yields and limited selectivity. Considering that the cyclization step during of cyclic is presumably most using a spontaneous selective system ideal. Here, we present topology transformation from linear cyclic, which achieved through error-checking ability provided dynamic covalent bonding between bis(2,2,6,6-tetramethylpiperidin-1-yl)disulfide (BiTEMPS) its stable radicals with high bond exchange rate. When applying this method biobased poly(isosorbide carbonate) (PIC), an attractive alternative conventional petroleum-based polycarbonates, high-molecular-weight were unexpectedly obtained. Since functionalization PICs has been traditionally copolymerization techniques, aimed introduce bonds establish novel methods for PICs. Interestingly, intramolecular in heterogeneous proceeded via ring-expansion polymerization-like mechanism, affording consisting PIC backbone BiTEMPS units as units. The resulting PIC-based applied reactions, providing effective approach block end-functionalized skeleton. These results demonstrate potential chemistry polymer synthesis.

Язык: Английский

Процитировано

0
Novel All-Polymer Nanocomposites Enable Manipulation of Mechanical Properties via Self-Assembly DOI

Jiajun Qu,

Tongkui Yue,

Hengheng Zhao

и другие.

Macromolecules, Год журнала: 2025, Номер unknown

Опубликована: Май 18, 2025

Язык: Английский

Процитировано

0
Efficient Cytosolic Delivery of Single-Chain Polymeric Artificial Enzymes for Intracellular Catalysis and Chemo-Dynamic Therapy DOI
Di Zheng, Jing Tao, Liping Jiang

и другие.

Journal of the American Chemical Society, Год журнала: 2024, Номер 147(1), С. 998 - 1007

Опубликована: Дек. 30, 2024

Designing artificial enzymes for in vivo catalysis presents a great challenge due to biomacromolecule contamination, poor biodistribution, and insufficient substrate interaction. Herein, we developed single-chain polymeric nanoparticles with Cu/N-heterocyclic carbene active sites (SCNP-Cu) function as peroxidase mimics chemo-dynamic therapy (CDT). Compared the enzyme based on unfolded linear polymer scaffold multichain cross-linked scaffold, SCNP-Cu exhibits improved tumor accumulation CDT efficiency both vitro vivo. Protein-like size of SCNP promotes passive diffusion, whereas positive surface charge allows its transcytosis deep penetration hence site. The submolecular compartments effectively protect from protein bindings, thereby providing "cleaner" microenvironment within living system. folded structure facilitates their cytosolic delivery free diffusion cytosol, ensuring efficient contact endogenous H2O2, situ generation toxic hydroxyl radicals (·OH), effective damage intracellular targets (i.e., lipids, nucleic acids). This work establishes versatile SCNP-based nanoplatforms developing catalysis.

Язык: Английский

Процитировано

2