Tailoring polymer architectures to drive molecular sieving in protein-polymer hybrids
Sustainable Chemistry and Pharmacy,
Год журнала:
2025,
Номер
45, С. 101988 - 101988
Опубликована: Март 14, 2025
Язык: Английский
Better Together: Photoredox/Copper Dual Catalysis in Atom Transfer Radical Polymerization
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 29, 2024
Abstract
Photomediated
Atom
Transfer
Radical
Polymerization
(photoATRP)
is
an
activator
regeneration
method,
which
allows
for
the
controlled
synthesis
of
well‐defined
polymers
via
light
irradiation.
Traditional
photoATRP
often
limited
by
need
high‐energy
ultraviolet
or
violet
light.
These
could
negatively
affect
control
and
selectivity
polymerization,
promote
side
reactions,
may
not
be
applicable
to
biologically
relevant
systems.
This
drawback
can
circumvented
introduction
catalytic
amount
photocatalysts,
absorb
visible
and/or
NIR
and,
therefore,
controlled,
regenerative
ATRP
performed
with
dual‐catalytic
cycle.
Herein,
a
critical
summary
recent
developments
in
field
dual‐catalysis
concerning
Cu‐catalyzed
provided.
Contributions
involved
species
are
examined
mechanistically,
followed
challenges
future
directions
towards
next
generation
advanced
functional
macromolecular
materials.
Язык: Английский
Heterogenous catalysis for oxygen tolerant photoredox atom transfer radical polymerization and small-molecule dehalogenation
Polymer Chemistry,
Год журнала:
2024,
Номер
15(41), С. 4264 - 4280
Опубликована: Янв. 1, 2024
Heterogeneous
photocatalysts
(PCs)
have
garnered
attention
for
their
sustainability
and
cost-effectiveness.
Язык: Английский
Artificial Zymogen Based on Protein–Polymer Hybrids
Biomacromolecules,
Год журнала:
2024,
Номер
25(11), С. 7433 - 7445
Опубликована: Окт. 18, 2024
This
study
explores
the
synthesis
and
application
of
artificial
zymogens
using
protein-polymer
hybrids
to
mimic
controlled
enzyme
activation
observed
in
natural
zymogens.
Pro-trypsin
(pro-TR)
pro-chymotrypsin
(pro-CT)
were
engineered
by
modifying
surfaces
trypsin
(TR)
chymotrypsin
(CT)
with
cleavable
peptide
inhibitors
utilizing
surface-initiated
atom
transfer
radical
polymerization.
These
exhibited
70
90%
reductions
catalytic
efficiency
for
pro-TR
pro-CT,
respectively,
due
inhibitory
effect
grafted
inhibitors.
The
CT
pro-CT
TR
resulted
1.5-
2.5-fold
increases
enzymatic
activity,
respectively.
Furthermore,
activated
triggered
an
cascade,
enabling
amplification
activity
through
a
dual
pro-protease
hybrid
system.
highlights
potential
therapeutic
interventions
biodetection
platforms
harnessing
cascades
precise
control
activity.
Язык: Английский
Modeling Hyperbranched Polymer Formation Via Atrp Using Dissipative Particle Dynamics
Опубликована: Янв. 1, 2024
Язык: Английский
Modeling Hyperbranched Polymer Formation via ATRP Using Dissipative Particle Dynamics
Polymer,
Год журнала:
2024,
Номер
312, С. 127620 - 127620
Опубликована: Сен. 11, 2024
Язык: Английский
Better Together: Photoredox/Copper Dual Catalysis in Atom Transfer Radical Polymerization
Angewandte Chemie,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 29, 2024
Abstract
Photomediated
Atom
Transfer
Radical
Polymerization
(photoATRP)
is
an
activator
regeneration
method,
which
allows
for
the
controlled
synthesis
of
well‐defined
polymers
via
light
irradiation.
Traditional
photoATRP
often
limited
by
need
high‐energy
ultraviolet
or
violet
light.
These
could
negatively
affect
control
and
selectivity
polymerization,
promote
side
reactions,
may
not
be
applicable
to
biologically
relevant
systems.
This
drawback
can
circumvented
introduction
catalytic
amount
photocatalysts,
absorb
visible
and/or
NIR
and,
therefore,
controlled,
regenerative
ATRP
performed
with
dual‐catalytic
cycle.
Herein,
a
critical
summary
recent
developments
in
field
dual‐catalysis
concerning
Cu‐catalyzed
provided.
Contributions
involved
species
are
examined
mechanistically,
followed
challenges
future
directions
towards
next
generation
advanced
functional
macromolecular
materials.
Язык: Английский