Cited by Biodegradable Nanobowls with Controlled Dents

Biodegradable Nanobowls with Controlled Dents DOI

и другие.

ACS Macro Letters, Год журнала: 2024, Номер unknown, С. 35 - 42

Опубликована: Дек. 19, 2024

Nanobowls show promising potential in biomedical applications, such as bioimaging, cargo delivery, and disease theranostics, due to their unique concave structure interior cavities. However, the lack of biodegradable nanobowls with manipulable size (especially dent size) still exists an obstacle for in-depth exploration application fields. Herein, polypeptide-based are successfully obtained by self-assembly a graft polypeptide [named TPE-P(GAAzo

Язык: Английский

[Cu^II(l-Phe)₂–H]⁺ Complex: A Versatile Selector for Wide Enantiomeric Excess Determination and Chiral Recognition in Complicated Matrices by Post-column Infusion LC–Energy-resolved MS/MS DOI

Xingcheng Gong,

Yang Yang, Ke Zhang

и другие.

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 8, 2025

Enantiomeric measurement of complicated matrices always challenges LC–MS/MS. Efforts were made here to pursue a fit-for-purpose chiral selector (CS) for LC–MS/MS and clarify the enantioselective mechanisms. After assaying diverse candidates 22 pairs enantiomers, differentiation was successful 15 when employing [CuII(l-Phe)2–H]+ as CS. With d- vs l-proline (Pro) representatives, diastereomeric complex ions such [CuII(d-Pro)(l-Phe)2–H]+ [CuII(l-Pro)(l-Phe)2–H]+ formed their featured fragment [CuII(d/l-Pro)(l-Phe)–H]+ exhibited different abundance ratios (R). R linearly correlated with enantiomeric excess (ee %), Rmax, termed value at optimal collision energy, enabled recognition. Crystallization both [CuII(d-Pro)(l-Phe)–2H] [CuII(l-Phe)2–2H] complexes, X-ray spectroscopy revealed that distorted square planar configuration by tetrahedrally coordinating Cu2+ two nitrogen atoms oxygen from (Phe)2 or (d-Pro)(l-Phe) led enantioselectivity. The constructed an octahedron core consisting six spatially orthometric coordination bonds around nuclear CuII. ΔG differences generations contributed MS/MS behaviors. Because mirror images between [CuII(l-Pro)(d-Phe)2–H]+, l-Pro solely completed ee % determination. By correlating %, simultaneous determination nine amino acid (AA) enantiomers reached in cell medium extracts. Through Rmax ΔG, recognition, even configurational determination, achieved AA pyranocoumarin matrices. Together, is eligible CS facilitate post-column infusion LC–energy-resolved allowing wide recognition samples.

Язык: Английский

Процитировано

Harnessing chirality: A new dawn in inorganic nanomaterial synthesis and biomedical applications DOI