Asian Journal of Pharmaceutical Sciences,
Год журнала:
2023,
Номер
18(4), С. 100827 - 100827
Опубликована: Июль 1, 2023
Nano-targeted
delivery
systems
have
been
widely
used
for
breast
tumor
drug
delivery.
Estrogen
receptors
are
considered
to
be
significant
target
due
their
overexpression
in
a
variety
of
cells.
However,
targeted
ligands
impact
on
the
safety
and
effectiveness
active
systems,
limiting
clinical
transformation
nanoparticles.
Phytoestrogens
shown
good
biosafety
characteristics
some
affinity
with
estrogen
receptor.
In
present
study,
molecular
docking
was
select
tanshinone
IIA
(Tan
IIA)
among
phytoestrogens
as
ligand
nanodelivery
modifications.
Modified
Tan
(Tan-NH2)
showed
profile
demonstrated
tumor-targeting,
anti-tumor
metastasis
effects.
Moreover,
utilized
Dox-loaded
mesoporous
silica
nanoparticles
via
chemical
modification
generate
nanocomposite
Tan-Dox-MSN.
Tan-Dox-MSN
had
uniform
particle
size,
dispersibility
high
loading
capacity.
Validation
experiments
vivo
vitro
that
it
also
better
targeting
ability,
effect
lower
toxicity
normal
organs.
These
results
supported
idea
receptor
could
improve
therapeutic
efficacy
nano-targeted
tumors.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(19)
Опубликована: Янв. 4, 2024
Abstract
The
blood–brain
barrier
(BBB)
is
a
tailored
system
of
capillary
endothelial
cells
intermixed
with
tight
junctions
and
adherent
that
regulates
the
transport
various
materials
substances
between
blood
vasculature
central
nervous
(CNS).
However,
in
cases
brain
diseases,
BBB's
protective
regulatory
effects
hamper
therapeutics
from
reaching
affected
sites
sufficient
quantities.
This
has
so
far
been
leading
challenge
treating
CNS
diseases
disorders.
For
this
problem
to
be
overcome,
recent
research
sought
develop
novel
modalities
achieve
efficient
therapy
alleviate
associated
symptoms.
Therefore,
numerous
strategies
have
operated
years
address
limitations
traditional
invasive
methods,
including
poor
penetration
serious
side
effects.
As
desperately
in‐demand
technology,
nanotheranostics
particularly
shown
promising
results.
Herein,
review
reports
advancements
techniques
nanotechnology‐based
developed
for
neurodegenerative
study
provides
comprehensive
data
on
subject
used
future
studies
management
disorders
diseases.
Abstract
The
blood–brain
barrier
(BBB)
severely
blocks
the
intracranial
accumulation
of
most
systemic
drugs.
Inspired
by
contribution
bacterial
outer
membrane
to
Escherichia
coli
K1
(EC‐K1)
binding
and
invasion
BBB
endothelial
cells
in
meningitis,
utilization
ability
EC‐K1
for
brain‐targeted
drug
delivery
construction
a
biomimetic
self‐assembled
nanoparticle
with
surface
featuring
lipopolysaccharide‐free
are
proposed.
penetration
nanoparticles
is
demonstrated
occur
through
transcellular
vesicle
transport
pathway,
which
at
least
partially
dependent
on
internalization,
endosomal
escape,
transcytosis
mediated
interactions
between
protein
A
gp96
cells.
This
nanoengineering
strategy
endows
loaded
drugs
prolonged
circulation,
interstitial
distribution,
extremely
high
biocompatibility.
Based
critical
roles
cancer
biology,
this
reveals
enormous
potential
delivering
therapeutics
treat
gp96‐overexpressing
malignancies.
Accounts of Chemical Research,
Год журнала:
2023,
Номер
56(12), С. 1578 - 1590
Опубликована: Май 23, 2023
ConspectusTheranostic
nanoparticles'
potential
in
tumor
treatment
has
been
widely
acknowledged
thanks
to
their
capability
of
integrating
multifaceted
functionalities
into
a
single
nanosystem.
Theranostic
nanoparticles
are
typically
equipped
with
an
inorganic
core
exploitable
physical
properties
for
imaging
and
therapeutic
functions,
bioinert
coatings
improved
biocompatibility
immunological
stealth,
controlled
drug-loading–release
modules,
the
ability
recognize
specific
cell
type
uptake.
Integrating
multiple
nanosized
construct
require
sophisticated
molecular
design
precise
execution
assembly
procedures.
Underlying
multifunctionality
theranostic
nanoparticles,
ligand
chemistry
plays
decisive
role
translating
theoretical
designs
fully
functionalized
nanoparticles.
The
hierarchy
is
usually
threefold.
As
they
serve
passivate
nanoparticle's
surface,
capping
ligands
form
first
layer
directly
interfacing
crystalline
lattice
core.
size
shape
largely
determined
by
property
so
that
have
profound
influences
on
surface
properties.
Capping
mostly
chemically
inert,
which
necessitates
presence
additional
drug
loading
targeting.
second
commonly
utilized
loading.
Therapeutic
drugs
can
either
be
covalently
conjugated
onto
or
noncovalently
loaded
via
drug-loading
ligands.
Drug-loading
need
equally
versatile
accommodate
diversity
drugs.
Biodegradable
moieties
often
incorporated
enable
smart
release.
With
aid
targeting
stand
tallest
nanoparticle
seek
bind
corresponding
receptors
target,
preferentially
accumulate
at
site
attain
higher
precision
quantity
delivery.
In
this
Account,
utilities
representative
ligands,
reviewed.
Since
these
types
assembled
close
vicinity
each
other,
it
essential
them
compatible
able
function
tandem
other.
Relevant
conjugation
strategies
critical
factors
significant
impact
ligands'
performance
discussed.
Representative
presented
showcase
how
different
synergistically
from
Finally,
technological
outlook
evolving
provided.
Aging and Disease,
Год журнала:
2024,
Номер
15(1), С. 169 - 169
Опубликована: Янв. 1, 2024
Brain
metastases
and
related
complications
are
one
of
the
major
fatal
factors
in
cancer.
Patients
with
breast
cancer,
lung
melanoma
at
a
high
risk
developing
brain
metastases.
However,
mechanisms
underlying
metastatic
cascade
remain
poorly
understood.
Microglia,
resident
macrophages
parenchyma,
involved
multiple
processes
associated
metastasis,
including
inflammation,
angiogenesis,
immune
modulation.
They
also
closely
interact
cancer
cells,
astrocytes,
other
cells.
Current
therapeutic
approaches
against
cancers,
small-molecule
drugs,
antibody-coupled
drugs
(ADCs),
immune-checkpoint
inhibitors
(ICIs),
have
compromised
efficacy
owing
to
impermeability
blood-brain
barrier
(BBB)
complex
microenvironment.
Targeting
microglia
is
strategies
for
treating
In
this
review,
we
summarize
multifaceted
roles
highlight
them
as
potential
targets
future
interventions.
Pharmaceutics,
Год журнала:
2021,
Номер
13(12), С. 2024 - 2024
Опубликована: Ноя. 27, 2021
The
blood-brain
barrier
(BBB)
precisely
controls
brain
microenvironment
and
neural
activity
by
regulating
substance
transport
into
out
of
the
brain.
However,
it
severely
hinders
drug
entry
brain,
efficiency
various
systemic
therapies
against
diseases.
Modulation
BBB
via
opening
tight
junctions,
inhibiting
active
efflux
and/or
enhancing
transcytosis,
possesses
potential
to
increase
permeability
improve
intracranial
concentrations
therapeutic
efficiency.
Various
strategies
modulation
have
been
reported
investigated
preclinically
clinically.
This
review
describes
conventional
emerging
related
mechanisms,
safety
issues
according
structures
functions,
try
give
more
promising
directions
for
designing
reasonable
preclinical
clinical
studies.
Pharmaceutics,
Год журнала:
2022,
Номер
14(10), С. 2092 - 2092
Опубликована: Сен. 30, 2022
Cancer
cells
normally
develop
the
ability
to
rewire
or
reprogram
themselves
become
resistant
treatments
that
were
previously
effective.
Despite
progress
in
understanding
drug
resistance,
knowledge
gaps
remain
regarding
underlying
biological
causes
of
resistance
and
design
cancer
overcome
it.
So,
acquisition
remains
a
major
problem
treatment.
Targeted
therapeutics
are
considered
next
generation
therapy
because
they
many
limitations
traditional
treatments.
Numerous
tumor
overexpress
several
receptors
have
high
binding
affinity
for
hyaluronic
acid
(HA),
while
poorly
expressed
normal
body
cells.
HA
its
derivatives
advantage
being
biocompatible
biodegradable
may
be
conjugated
with
variety
drugs
carriers
developing
various
formulations
as
anticancer
therapies
such
micelles,
nanogels,
inorganic
nanoparticles.
Due
their
stability
blood
circulation
predictable
delivery
patterns,
enhanced
tumor-selective
accumulation,
decreased
toxicity
tissues,
tumor-targeting
nanomaterial-based
systems
been
shown
represent
an
efficacious
approach
treatment
cancer.
In
this
review,
we
aim
provide
overview
some
vitro
vivo
studies
related
potential
ligand
targeted
nanovehicles
future
biomedical
applications
