A Multifunctional MIL-101-NH2(Fe) Nanoplatform for Synergistic Melanoma Therapy

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 969 - 988

Опубликована: Янв. 1, 2025

Melanoma is an aggressive form of skin cancer, and single-modality treatments often fail to prevent tumor recurrence metastasis. Combination therapy has emerged as effective approach improve treatment outcomes. In this study, we developed a multifunctional nanoplatform, MIL@DOX@ICG, utilizing MIL-101-NH2(Fe) carrier co-deliver the chemotherapeutic agent doxorubicin (DOX) photosensitizer indocyanine green (ICG). was synthesized via hydrothermal method. Drug release evaluated under different pH conditions, photothermal effect tested near-infrared (NIR) laser irradiation. Hydroxyl radical reactive oxygen species generation capacities were quantified. Cellular studies using B16F10 cells assessed cytotoxicity, cellular uptake, migration inhibition, colony formation suppression. vivo experiments in melanoma-bearing mice antitumor efficacy systemic safety through growth histological analyses, toxicity assessments. MIL@DOX@ICG exhibited uniform octahedral structure with particle size approximately 139 nm high drug loading efficiencies for DOX (33.70%) ICG (30.59%). The nanoplatform demonstrated pH-responsive potent effects. hydroxyl radicals Fenton reaction production NIR irradiation by confirmed. vitro assessments revealed significant cytotoxicity against irradiation, improved inhibiting cell proliferation migration. confirmed superior + treatment, synergistically harnessing chemotherapy, therapy, photodynamic chemodynamic effects while maintaining excellent biocompatibility. Our findings underscore potential nanoparticles versatile platform synergistic melanoma offering promising strategy overcoming limitations conventional modalities.

Язык: Английский

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Progress of metal-organic frameworks in improving the effect of sonodynamic therapy

Biomedical Technology, Год журнала: 2025, Номер 9, С. 100070 - 100070

Опубликована: Фев. 14, 2025

Язык: Английский

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GSH-Responsive Prodrug Nanoassembly as a Carrier-Free Nanoplatform for Tumor-Targeting Delivery and Chemo-Photothermal Therapy

Molecular Pharmaceutics, Год журнала: 2023, Номер 20(8), С. 4210 - 4218

Опубликована: Июль 18, 2023

Photothermal therapy, combined with chemotherapy, holds promising prospects for the therapeutic outcome of malignant tumors. However, synergistic effect suffers from low coloading capacity and inefficient synchronous tumor-targeting delivery chemodrug photothermal photosensitizers. Herein, we designed a versatile carrier-free nanoplatform to seek improvement chemo-photothermal therapy. An NIR photosensitizer IR-808 was used noninvasive cancer imaging, diagnosis, imaging-guided A reduction-sensitive paclitaxel prodrug (PTX-SS-PEG2k) rationally synthesized by covalently linking polyethylene glycol 2000 via disulfide bond. Then, nanoassemblies were constructed an inner core amphiphilic shell. PTX-SS-PEG2k served as stabilizer could facilitate self-assembly nanoparticles high efficiency drug release. The exhibited multiple advantages, including payload, release, delivery, potent antitumor effect. We provide theranostic nanoplatform, which improves effectiveness synergetic therapy reduces off-target toxicity.

Язык: Английский

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Novel micro/nanomotors for tumor diagnosis and therapy: Motion mechanisms, advantages and applications

Journal of Science Advanced Materials and Devices, Год журнала: 2024, Номер 9(2), С. 100718 - 100718

Опубликована: Апрель 16, 2024

The lack of effective diagnostic and therapeutic techniques is a crucial cause the high clinical mortality for malignancy. Notably, self-propelled micro/nanomotors are expected to address drawbacks by conventional nanoparticles in tumor diagnosis therapy. special locomotion property ensures efficiency on rapid distribution, deep penetration targeting delivery. Hence, this review, motion mechanism controllability speed direction were described, as well advantages regarding enhancement biological barrier crossing (overcoming blood flow obstacles, microenvironment barriers), delivery tumor. most recent advances micro/nanomotor contributions comprehensively summarized various medical imaging technologies, biosensing techniques, approaches, especially combination therapy integration treatment based multifunctional micro/nanomotors. Furthermore, challenges developing practical discussed along with future directions from clinicians' perspective, which promised up translation process contribute efficient

Язык: Английский

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Coassembled Nanoparticles Constructed from Trisulfide Bond-Modified Docetaxel and Hematoporphyrin for Treating 4T1 Breast Tumors

ACS Applied Nano Materials, Год журнала: 2024, Номер unknown

Опубликована: Окт. 25, 2024

Язык: Английский

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