Recent Advances in the Development of Sigma Receptor (Radio)Ligands and Their Application in Tumors

ACS Pharmacology & Translational Science, Год журнала: 2025, Номер 8(4), С. 951 - 977

Опубликована: Март 7, 2025

Cancer ranks among the top triumvirate leading causes of human deaths worldwide. The pathological mechanisms are notably intricate, demonstrating proliferative and metastatic capabilities, which complicate therapeutic interventions. sigma-1 receptor (σ1R) plays a crucial role in tumor survival migration, while sigma-2 (σ2R) is intimately associated with proliferation. This review encapsulated investigation concerning σ1R σ2R neoplasms rigorously summarized ligands radio-ligands development their applications, such as antitumor cell proliferation PET/SPECT imaging tumors. A comprehensive classification discussion was undertaken regarding chemical structures emphasized possibility dual/multitargeted ligands. Ultimately, we discussed effects chiral pharmacological characteristics on affinity pharmacokinetic features vivo, particularly radiopharmaceuticals. functions beneficial resource, fostering ligand deployment stimulating generation innovative ideas for developing

Язык: Английский

Neuroreceptor Mapping in 2024

ACS Chemical Neuroscience, Год журнала: 2024, Номер unknown

Опубликована: Дек. 9, 2024

Neuroreceptor mapping provides insights into neurotransmitter changes and receptor dynamics that improve the understanding of brain functions. This Viewpoint highlights advancements in development novel radiotracers (imaging tools) quantification based on presentations from

Язык: Английский