Exploring tumor-associated macrophages in glioblastoma: from diversity to therapy DOI Creative Commons
Wenwen Zhao, Zhang Zhi, Mingyuan Xie

и другие.

npj Precision Oncology, Год журнала: 2025, Номер 9(1)

Опубликована: Май 2, 2025

Glioblastoma is the most aggressive and lethal cancer of central nervous system, presenting substantial treatment challenges. The current standard treatment, which includes surgical resection followed by temozolomide radiation, offers limited success. While immunotherapies, such as immune checkpoint inhibitors, have proven effective in other cancers, they not demonstrated significant efficacy GBM. Emerging research highlights pivotal role tumor-associated macrophages (TAMs) supporting tumor growth, fostering resistance, shaping an immunosuppressive microenvironment. Preclinical studies show promising results for therapies targeting TAMs, suggesting potential overcoming these barriers. TAMs consist brain-resident microglia bone marrow-derived macrophages, both exhibiting diverse phenotypes functions within This review delves into origin, heterogeneity, functional roles GBM, underscoring their dual promotion suppression. It also summarizes recent progress TAM-targeted therapies, may, combination with treatments like immunotherapy, pave way more personalized strategies against this malignancy.

Язык: Английский

Exploring tumor-associated macrophages in glioblastoma: from diversity to therapy DOI Creative Commons
Wenwen Zhao, Zhang Zhi, Mingyuan Xie

и другие.

npj Precision Oncology, Год журнала: 2025, Номер 9(1)

Опубликована: Май 2, 2025

Glioblastoma is the most aggressive and lethal cancer of central nervous system, presenting substantial treatment challenges. The current standard treatment, which includes surgical resection followed by temozolomide radiation, offers limited success. While immunotherapies, such as immune checkpoint inhibitors, have proven effective in other cancers, they not demonstrated significant efficacy GBM. Emerging research highlights pivotal role tumor-associated macrophages (TAMs) supporting tumor growth, fostering resistance, shaping an immunosuppressive microenvironment. Preclinical studies show promising results for therapies targeting TAMs, suggesting potential overcoming these barriers. TAMs consist brain-resident microglia bone marrow-derived macrophages, both exhibiting diverse phenotypes functions within This review delves into origin, heterogeneity, functional roles GBM, underscoring their dual promotion suppression. It also summarizes recent progress TAM-targeted therapies, may, combination with treatments like immunotherapy, pave way more personalized strategies against this malignancy.

Язык: Английский

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