The role of organic acid counterions in modulating the in-vitro dissolution and permeability profiles of procaine salts DOI Creative Commons

Paola Disisto,

Laura Baraldi, Luca Fornasari

и другие.

European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2025, Номер 213, С. 114758 - 114758

Опубликована: Май 26, 2025

Язык: Английский

Prodrug Approach as a Strategy to Enhance Drug Permeability DOI Creative Commons
Mariana Moraes Dionysio de Souza, Ana Luísa Rodriguez Gini,

Jhonnathan Alves Moura

и другие.

Pharmaceuticals, Год журнала: 2025, Номер 18(3), С. 297 - 297

Опубликована: Фев. 21, 2025

Absorption and permeability are critical physicochemical parameters that must be balanced to achieve optimal drug uptake. These key factors closely linked the maximum absorbable dose required provide appropriate plasma levels of drugs. Among various strategies employed enhance solubility permeability, prodrug design stands out as a highly effective versatile approach for improving properties enabling optimization biopharmaceutical pharmacokinetic while mitigating adverse effects. Prodrugs compounds with reduced or no activity that, through bio-reversible chemical enzymatic processes, release an active parental drug. The application this technology has led significant advancements in during phase, it offers broad potential further development. Notably, approximately 13% drugs approved by U.S. Food Drug Administration (FDA) between 2012 2022 were prodrugs. In review article, we will explore describing examples market We also describe use optimize PROteolysis TArgeting Chimeras (PROTACs) using conjugation technologies. highlight some new technologies prodrugs enrich properties, contributing developing safe

Язык: Английский

Процитировано

0
Development of novel amino-benzenesulfonamide derivatives and their analogues as carbonic anhydrase inhibitors: Design, synthesis, anticancer activity assessment, and pharmacokinetic studies using UPLC-MS/MS DOI
Khaled Elsayad, Ghada F. Elmasry, Sally Tarek Mahmoud

и другие.

Bioorganic Chemistry, Год журнала: 2025, Номер 159, С. 108335 - 108335

Опубликована: Март 6, 2025

Язык: Английский

Процитировано

0
Crystal Engineering Strategies for Optimizing Skin Permeation DOI
Ali Samie, Hoda Alavian

Crystal Growth & Design, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Язык: Английский

Процитировано

0
Three Indomethacin cocrystals: preparation, characterization and formation thermodynamics DOI
Ying Zhang, Jingjing Liu,

Ling Yin

и другие.

Process Safety and Environmental Protection, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Enhancing the Oral Bioavailability of an Antiviral Drug Acyclovir by Crystal Engineering of Novel Pharmaceutical Cocrystals DOI

Lohith Kotte,

Anshu Gupta,

Hari Priya Sripadi

и другие.

Crystal Growth & Design, Год журнала: 2025, Номер unknown

Опубликована: Май 13, 2025

Язык: Английский

Процитировано

0
The role of organic acid counterions in modulating the in-vitro dissolution and permeability profiles of procaine salts DOI Creative Commons

Paola Disisto,

Laura Baraldi, Luca Fornasari

и другие.

European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2025, Номер 213, С. 114758 - 114758

Опубликована: Май 26, 2025

Язык: Английский

Процитировано

0