Shaping Polarization Of Tumor-Associated Macrophages In Cancer Immunotherapy

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Июнь 30, 2022

Different stimuli can polarize macrophages into two basic types, M1 and M2. Tumor-associated (TAMs) in the tumor microenvironment (TME) are composed of heterogeneous subpopulations, which include anti-tumor M2 pro-tumor phenotypes. TAMs predominantly play a M2-like tumor-promoting role TME regulate various malignant effects, such as angiogenesis, immune suppression, metastasis; hence, have emerged hot topic research cancer therapy. This review focuses on three main aspects TAMs. First, we summarize macrophage polarization along with effects TME. Second, recent advances challenges treatment checkpoint blockade CAR-T cell therapy emphasized. Finally, factors, signaling pathways, associated TAM potential strategies for targeting repolarization to pro-inflammatory phenotype discussed.

Язык: Английский

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Tumor-associated macrophages in cancer: recent advancements in cancer nanoimmunotherapies

Journal of Experimental & Clinical Cancer Research, Год журнала: 2022, Номер 41(1)

Опубликована: Фев. 19, 2022

Abstract Cancer immunotherapy has emerged as a novel cancer treatment, although recent trials have produced suboptimal outcomes, with durable responses seen only in small number of patients. The tumor microenvironment (TME) been shown to be responsible for immune escape and therapy failure. vital component the TME is tumor-associated macrophages (TAMs), which are usually associated poor prognosis drug resistance, including immunotherapies, promising targets immunotherapy. Recently, nanoparticles, because their unique physicochemical characteristics, crucial translational moieties tackling tumor-promoting TAMs that amplify sensitize tumors immunotherapies safe effective manner. In this review, we mainly described current potential nanomaterial-based therapeutic strategies target TAMs, restricting survival, inhibiting recruitment functionally repolarizing tumor-supportive antitumor type. understanding origin polarization role progression prognostic significance was also discussed review. We highlighted evolution chimeric antigen receptor (CAR)-macrophage cell therapy.

Язык: Английский

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Targeting M2-like tumor-associated macrophages is a potential therapeutic approach to overcome antitumor drug resistance

npj Precision Oncology, Год журнала: 2024, Номер 8(1)

Опубликована: Фев. 10, 2024

Abstract Tumor drug resistance emerges from the interaction of two critical factors: tumor cellular heterogeneity and immunosuppressive nature microenvironment (TME). Tumor-associated macrophages (TAMs) constitute essential components TME. M2-like TAMs are in facilitating metastasis as well augmenting tumors. This review encapsulates mechanisms that use to promote resistance. We also describe emerging therapeutic strategies currently targeting combination with other antitumor drugs, some still undergoing clinical trial evaluation. Furthermore, we summarize analyze various existing approaches for developing novel drugs target overcome resistance, highlighting how can effectively stop growth, metastasis,

Язык: Английский

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Biomedical polymers: synthesis, properties, and applications

Science China Chemistry, Год журнала: 2022, Номер 65(6), С. 1010 - 1075

Опубликована: Апрель 24, 2022

Язык: Английский

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Regulatory cells and the effect of cancer immunotherapy

Molecular Cancer, Год журнала: 2023, Номер 22(1)

Опубликована: Фев. 4, 2023

Abstract Several mechanisms and cell types are involved in the regulation of immune response. These include mostly regulatory T cells (Tregs), macrophages (Mregs), myeloid suppressor (MDSCs) other such as tolerogenic dendritic (tolDCs), B (Bregs), mesenchymal stem (MSCs). cells, known for their ability to suppress responses, can also anti-tumor The infiltration many into tumor tissues is therefore associated with a poor prognosis. There growing evidence that elimination Tregs enhances responses. However, systemic depletion Treg simultaneously cause deleterious autoimmunity. Furthermore, since characterized by high level expression checkpoints, it expected checkpoint inhibitors perform part function blocking these molecules enhancing This indicates immunotherapy does not only act activating specific effector but directly or indirectly attenuate suppressive activity tissues. review aims draw together our current knowledge about effect on various how effects may be beneficial response immunotherapy.

Язык: Английский

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Orchestrated Yolk–Shell Nanohybrids Regulate Macrophage Polarization and Dendritic Cell Maturation for Oncotherapy with Augmented Antitumor Immunity

Advanced Materials, Год журнала: 2022, Номер 34(9)

Опубликована: Янв. 12, 2022

The protumoral and immunosuppressive tumor microenvironments greatly limit the antitumor immune responses of nanoparticles for cancer immunotherapy. Here, intrinsic immunomodulatory effects orchestrated their ability to simultaneously trigger antigen release, thereby reversing immunosuppression achieving potent immunity augmented therapy, are explored. By optimizing both composition morphology, a facile strategy is proposed construct yolk-shell nanohybrids (Fe3 O4 @C/MnO2 -PGEA, FCMP). FCMP utilized reprogram macrophages M1 phenotype induce maturation dendritic cells. In addition, chemical, magnetic, optical properties contribute amplified immunogenic cell death induced by multiaugmented chemodynamic therapy (CDT) synergistic treatment. Taking advantage unique structure, accurate T1 -T2 dual-mode magnetic resonance imaging can be realized CDT maximized through sufficient exposure Fe3 core MnO2 shell. Potent found substantially inhibit growth primary distant tumors. Furthermore, extended synthesis other with tailored properties. This work establishes novel fabrication multifunctional nanoplatforms structure effective immunomodulation-enhanced immunity.

Язык: Английский

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An acid-responsive MOF nanomedicine for augmented anti-tumor immunotherapy via a metal ion interference-mediated pyroptotic pathway

Biomaterials, Год журнала: 2023, Номер 302, С. 122333 - 122333

Опубликована: Сен. 16, 2023

Язык: Английский

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Biodegradable NIR‐II Pseudo Conjugate Polymeric Nanoparticles Amplify Photodynamic Immunotherapy via Alleviation of Tumor Hypoxia and Tumor‐Associated Macrophage Reprogramming

Advanced Materials, Год журнала: 2023, Номер 35(31)

Опубликована: Июнь 7, 2023

Photodynamic therapy (PDT) has achieved great success in cancer treatment. Despite its promise, the efficacy of photodynamic immunotherapy can be limited by hypoxia solid tumors which is closely related to abnormal tumor vasculature. These vasculatures are a hallmark most and facilitate immune evasion. Therefore, vascular normalization developed as promising strategy overcome hypoxia, resulting improved therapy. Here, NIR-II bio-degradable pseudo-conjugate polymer (PSP)-based designed deliver agent, i.e., regorafenib (Reg) nanoparticles (NP-PDT@Reg). NP-PDT@Reg under 808 nm laser irradiation (NP-PDT@Reg + L) efficiently release Reg improve via normalization, making more oxygen enter tumors. Moreover, L further result generation reactive species (ROS) eradicate cells while inducing immunogenic cell death (ICD) activate anti-tumor responses. In addition, reprogram TAM from pro-tumor M2 phenotype tumor-killing M1 well, thereby reversing immunosuppressive microenvironment. Taken together, current study provides an innovative perspective on development novel nanomaterials limitations immunotherapy.

Язык: Английский

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Biomedical applications of PLGA nanoparticles in nanomedicine: advances in drug delivery systems and cancer therapy

Expert Opinion on Drug Delivery, Год журнала: 2023, Номер 20(7), С. 937 - 954

Опубликована: Июнь 9, 2023

During the last decades, ever-increasing proportion of patients with cancer has been led to serious concerns worldwide. Therefore, development and use novel pharmaceuticals, like nanoparticles (NPs)-based drug delivery systems (DDSs), can be potentially effective in therapy.Poly lactic-co-glycolic acid (PLGA) NPs, as a kind bioavailable, biocompatible, biodegradable polymers, have approved by Food Drug Administration (FDA) for some biomedical pharmaceutical applications. PLGA is comprised lactic (LA) glycolic (GA) their ratio could controlled during various syntheses preparation approaches. LA/GA determines stability degradation time PLGA; lower content GA results fast degradation. There are several approaches preparing NPs that affect aspects, such size, solubility, stability, loading, pharmacokinetics, pharmacodynamics, so on.These indicated sustained release site passive active (via surface modification) DDSs. This review aims provide an overview approach physicochemical mechanism cellular fate, DDSs efficient therapy, status industry nanomedicine.

Язык: Английский

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Microbe‐Mediated Biosynthesis of Multidimensional Carbon‐Based Materials for Energy Storage Applications

Advanced Energy Materials, Год журнала: 2023, Номер 13(19)

Опубликована: Апрель 5, 2023

Abstract Biosynthesis methods are considered to be a promising technology for engineering new carbon‐based materials or redesigning the existing ones specific purposes with aid of synthetic biology. Lots biosynthetic processes including metabolism, fermentation, biological mineralization, and gene editing have been adopted prepare novel exceptional properties that cannot realized by traditional chemical methods, because microbes evolved possess special abilities modulate components/structure materials. In this review, recent development on prepared via different biosynthesis various microbe factories (such as bacteria, yeasts, fungus, viruses, proteins) systematically reviewed. The types biotechniques corresponding mechanisms synthesis outlined. This review also focuses structural design compositional nanostructures (e.g., metals, semiconductors, metal oxides, sulfides, phosphates, Mxenes) derived from biotechnology their applications in electrochemical energy storage devices. Moreover, relationship architecture–composition–electrochemical behavior performance enhancement mechanism is deeply discussed analyzed. Finally, perspectives challenges carbons proposed may pave avenue rational advanced low‐carbon economy.

Язык: Английский

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