Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Окт. 19, 2023
Abstract
Immunotherapy
has
good
potential
to
eradicate
tumors
in
the
long
term.
However,
due
low
immunogenicity
of
tumor
cells,
current
cancer
immunotherapies
are
not
effective.
To
address
this
limitation,
we
constructed
a
BSA-FA
functionalized
iron-containing
metal-organic
framework
(TPL@TFBF)
that
triggers
potent
systemic
anti-tumor
immune
response
by
inducing
ferroptosis
and
pyroptosis
cells
releasing
large
quantities
damage-associated
molecular
patterns
(DAMPs)
induce
immunogenicity,
showing
excellent
efficacy
against
melanoma
lung
metastases
vivo.
This
nanoplatform
forms
through
coordination
between
tannic
acid
(TA)
Fe
3+
is
then
loaded
with
triptolide
(TPL),
which
coated
FA-modified
BSA.
The
nanoparticles
target
FA
modification,
TPL,
TA.
reduced
2+
TA,
triggering
Fenton
reaction
resulting
ROS
production.
Moreover,
TPL
increases
production
intracellular
inhibiting
expression
nuclear
factor
erythroid-2
related
(Nrf2).
Such
simultaneous
amplification
induces
undergo
pyroptosis,
amounts
DAMPs,
stimulate
antigen
presentation
dendritic
(DCs)
proliferation
cytotoxic
T
lymphocytes
(CD4+/CD8
+
cells)
inhibit
metastasis.
In
addition,
combining
nanoparticle
treatment
checkpoint
blockade
(ICB)
further
inhibits
growth.
work
provides
new
strategy
for
immunotherapy
based
on
various
combinations
cell
death
mechanisms.
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Март 30, 2022
The
demise
of
cells
in
various
ways
enables
the
body
to
clear
unwanted
cells.
Studies
over
years
revealed
distinctive
molecular
mechanisms
and
functional
consequences
several
key
cell
death
pathways.
Currently,
most
intensively
investigated
programmed
(PCD)
includes
apoptosis,
necroptosis,
pyroptosis,
ferroptosis,
PANoptosis,
autophagy,
which
has
been
discovered
play
crucial
roles
modulating
immunosuppressive
tumor
microenvironment
(TME)
determining
clinical
outcomes
cancer
therapeutic
approaches.
PCD
can
dual
roles,
either
pro-tumor
or
anti-tumor,
partly
depending
on
intracellular
contents
released
during
process.
also
regulates
enrichment
effector
regulatory
immune
cells,
thus
participating
fine-tuning
anti-tumor
immunity
TME.
In
this
review,
we
focused
primarily
discussed
messengers
regulating
their
intricate
crosstalk
with
response
TME,
explored
immunological
consequence
its
implications
future
therapy
developments.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(10)
Опубликована: Янв. 11, 2023
Although
zeolitic
imidazolate
framework-8
(ZIF-8)
has
been
applied
in
various
tumor
therapies,
the
intrinsic
immunogenicity
remains
unclear.
Here,
we
initiatively
discover
that
ZIF-8
nanoparticles
(NPs)
can
intrinsically
induce
pyroptosis
by
a
caspase-1/gasdermin
D
(GSDMD)-dependent
pathway.
The
pyroptotic
cell
death
is
accompanied
necrosis
and
immunogenic
(ICD)
simultaneously
for
efficient
situ
immunity
initiation.
Meanwhile,
carbonyl
cyanide
m-chlorophenyl
hydrazone
(CCCP),
mitochondrial
depolarizing
agent,
successfully
loaded
into
NPs
found
to
further
enhance
process.
Collectively,
obtained
Pluronic
F127-modified
CCCP-incorporated
(F127
ZIF-8CCCP
NPs)
activate
antitumor
reprogram
immunosuppressive
microenvironment
(TME),
realizing
high-efficiency
growth
inhibition.
This
work
will
facilitate
biomedicine
applications
of
provide
good
inspiration
pyroptosis-induced
cancer
therapy.
Journal of Hematology & Oncology,
Год журнала:
2024,
Номер
17(1)
Опубликована: Апрель 2, 2024
Abstract
Cancer
immunotherapy
and
vaccine
development
have
significantly
improved
the
fight
against
cancers.
Despite
these
advancements,
challenges
remain,
particularly
in
clinical
delivery
of
immunomodulatory
compounds.
The
tumor
microenvironment
(TME),
comprising
macrophages,
fibroblasts,
immune
cells,
plays
a
crucial
role
response
modulation.
Nanoparticles,
engineered
to
reshape
TME,
shown
promising
results
enhancing
by
facilitating
targeted
These
nanoparticles
can
suppress
fibroblast
activation,
promote
M1
macrophage
polarization,
aid
dendritic
cell
maturation,
encourage
T
infiltration.
Biomimetic
further
enhance
increasing
internalization
agents
cells
such
as
cells.
Moreover,
exosomes,
whether
naturally
secreted
body
or
bioengineered,
been
explored
regulate
TME
immune-related
affect
cancer
immunotherapy.
Stimuli-responsive
nanocarriers,
activated
pH,
redox,
light
conditions,
exhibit
potential
accelerate
co-application
with
checkpoint
inhibitors
is
an
emerging
strategy
boost
anti-tumor
immunity.
With
their
ability
induce
long-term
immunity,
nanoarchitectures
are
structures
development.
This
review
underscores
critical
overcoming
current
driving
advancement
modification.
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(36)
Опубликована: Июнь 10, 2022
Abstract
Pyroptosis
provides
a
new
direction
and
broad
prospects
for
cancer
immunotherapy.
However,
the
development
of
nanoplatform
as
pyroptosis
inducer
is
limited,
discovery
type
nano‐pyroptosis
immunotherapy
still
imminent.
Herein,
biodegradable
Ca
2+
nanomodulators
(CaNMs)
are
prepared
inducers
via
mitochondrial
overload.
The
obtained
CaNMs
can
decompose
under
low
pH
to
release
curcumin,
leading
sudden
surge
in
ions,
eventually
resulting
pyroptosis.
We
not
only
confirm
occurrence
overload‐triggered
first
time
but
also
reveal
robust
immune
responses
CaNMs,
along
with
remarkably
suppressing
tumor
proliferation
lung
metastasis.
This
work
will
provide
strategies
inspiration
pyroptosis‐mediated
treatments,
greatly
contributing
further
nanomodulators.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(6), С. 2031 - 2081
Опубликована: Янв. 1, 2023
Bioactive
materials
are
a
special
class
of
biomaterials
that
can
react
in
vivo
to
induce
biological
response
or
regulate
functions,
thus
achieving
better
curative
effect
than
traditional
inert
biomaterials.
For
cancer
theranostics,
compared
with
organic
polymer
nanomaterials,
inorganic
nanomaterials
possess
unique
physical
and
chemical
properties,
have
stronger
mechanical
stability
on
the
basis
maintaining
certain
bioactivity,
easy
be
compounded
various
carriers
(polymer
carriers,
etc.),
so
as
achieve
specific
antitumor
efficacy.
After
entering
nanoscale,
due
nano-size
effect,
high
surface
area
nanostructures,
exhibit
effects,
which
significantly
influence
interaction
organisms.
Therefore,
research
applications
bioactive
theranostics
attracted
wide
attention.
In
this
review,
we
mainly
summarize
recent
progress
also
introduce
definition,
synthesis
modification
strategies
nanomaterials.
Thereafter,
tumor
imaging
therapy,
including
microenvironment
(TME)
regulation,
catalytic
gas
regulatory
cell
death
immunotherapy,
discussed.
Finally,
biosafety
challenges
mentioned,
their
future
development
opportunities
prospected.
This
review
highlights
bioapplication
Abstract
Metal‐based
nanomaterials
have
attracted
broad
attention
recently
due
to
their
unique
biological
physical
and
chemical
properties
after
entering
tumor
cells,
namely
effects.
In
particular,
the
abilities
of
Ca
2+
modulate
T
cell
receptors
activation,
K
+
regulate
stem
differentiation,
Mn
activate
STING
pathway,
Fe
2+/3+
induce
ferroptosis
enhance
catalytic
therapy,
make
metal
ions
metal‐based
play
crucial
roles
in
cancer
treatments.
Therefore,
superior
advantages
characteristics
microenvironment,
we
will
summarize
recent
progress
anti‐tumor
effects
nanomaterials.
Based
on
different
this
review
mainly
focuses
following
five
aspects:
(1)
metal‐enhanced
radiotherapy
sensitization,
(2)
(3)
ferroptosis,
(4)
pyroptosis,
(5)
immunotherapy.
At
same
time,
shortcomings
therapy
are
also
discussed,
future
research
directions
been
prospected.
The
highlights
promising
biosafety,
potent
efficacy
for
in‐depth
various
mechanism
studies
provide
novel
ideas
application
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(40)
Опубликована: Авг. 17, 2023
Abstract
Although
immunotherapy
has
a
broad
clinical
application
prospect,
it
is
still
hindered
by
low
immune
responses
and
immunosuppressive
tumor
microenvironment.
Herein,
simple
drug‐free
inorganic
nanomaterial,
alkalescent
sodium
bicarbonate
nanoparticles
(NaHCO
3
NPs),
prepared
via
fast
microemulsion
method
for
amplified
cancer
immunotherapy.
The
obtained
NaHCO
regulates
lactic
acid
metabolism
through
acid‐base
neutralization
so
as
to
reverse
the
mildly
acidic
environment.
Additionally,
can
further
release
high
amounts
of
Na
+
ions
inside
cells
induce
surge
in
intracellular
osmolarity,
thus
activate
pyroptosis
pathway
immunogenic
cell
death
(ICD),
damage‐associated
molecular
patterns
(DAMPs)
inflammatory
factors,
improve
responses.
Collectively,
NPs
observably
inhibit
primary/distal
growth
metastasis
remitted
immunosuppression
induced
activation,
showing
an
enhanced
antitumor
immunity
efficiency.
This
work
provides
new
paradigm
mediated
treatment,
which
potential
Abstract
Programmed
cell
death
(PCD,
mainly
including
apoptosis,
necrosis,
ferroptosis,
pyroptosis,
and
autophagy)
immunogenic
(ICD),
as
important
mechanisms,
are
widely
reported
in
cancer
therapy,
understanding
the
relationship
between
two
is
significant
for
clinical
tumor
treatments.
Considering
that
vast
nanodrugs
developed
to
induce
PCD
ICD
simultaneously,
this
review,
interrelationship
described
using
nanomedicines
examples.
First,
an
overview
of
patterns
focus
on
morphological
differences
interconnections
among
them
provided.
Then
apoptosis
terms
endoplasmic
reticulum
stress
by
introducing
various
treatments
recent
developments
with
inducible
immunogenicity.
Next,
crosstalk
non‐apoptotic
(including
signaling
pathways
introduced
their
through
examples
further
illustrated.
Finally,
its
application
prospects
development
new
nanomaterials
summarized.
This
review
believed
deepen
ICD,
extend
biomedical
applications
nanodrugs,
promote
progress
therapy.