Combination of ferroptosis and pyroptosis dual induction by triptolide nano-MOFs for immunotherapy of Melanoma DOI Creative Commons

Shengmei Wang,

Qiuyan Guo,

Rubing Xu

и другие.

Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)

Опубликована: Окт. 19, 2023

Abstract Immunotherapy has good potential to eradicate tumors in the long term. However, due low immunogenicity of tumor cells, current cancer immunotherapies are not effective. To address this limitation, we constructed a BSA-FA functionalized iron-containing metal-organic framework (TPL@TFBF) that triggers potent systemic anti-tumor immune response by inducing ferroptosis and pyroptosis cells releasing large quantities damage-associated molecular patterns (DAMPs) induce immunogenicity, showing excellent efficacy against melanoma lung metastases vivo. This nanoplatform forms through coordination between tannic acid (TA) Fe 3+ is then loaded with triptolide (TPL), which coated FA-modified BSA. The nanoparticles target FA modification, TPL, TA. reduced 2+ TA, triggering Fenton reaction resulting ROS production. Moreover, TPL increases production intracellular inhibiting expression nuclear factor erythroid-2 related (Nrf2). Such simultaneous amplification induces undergo pyroptosis, amounts DAMPs, stimulate antigen presentation dendritic (DCs) proliferation cytotoxic T lymphocytes (CD4+/CD8 + cells) inhibit metastasis. In addition, combining nanoparticle treatment checkpoint blockade (ICB) further inhibits growth. work provides new strategy for immunotherapy based on various combinations cell death mechanisms.

Язык: Английский

Programmed Cell Death Tunes Tumor Immunity DOI Creative Commons
Jing Liu,

Minjing Hong,

Yijia Li

и другие.

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Март 30, 2022

The demise of cells in various ways enables the body to clear unwanted cells. Studies over years revealed distinctive molecular mechanisms and functional consequences several key cell death pathways. Currently, most intensively investigated programmed (PCD) includes apoptosis, necroptosis, pyroptosis, ferroptosis, PANoptosis, autophagy, which has been discovered play crucial roles modulating immunosuppressive tumor microenvironment (TME) determining clinical outcomes cancer therapeutic approaches. PCD can dual roles, either pro-tumor or anti-tumor, partly depending on intracellular contents released during process. also regulates enrichment effector regulatory immune cells, thus participating fine-tuning anti-tumor immunity TME. In this review, we focused primarily discussed messengers regulating their intricate crosstalk with response TME, explored immunological consequence its implications future therapy developments.

Язык: Английский

Процитировано

232

ZIF‐8 Nanoparticles Evoke Pyroptosis for High‐Efficiency Cancer Immunotherapy DOI
Binbin Ding, Hao Chen, Jia Tan

и другие.

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(10)

Опубликована: Янв. 11, 2023

Although zeolitic imidazolate framework-8 (ZIF-8) has been applied in various tumor therapies, the intrinsic immunogenicity remains unclear. Here, we initiatively discover that ZIF-8 nanoparticles (NPs) can intrinsically induce pyroptosis by a caspase-1/gasdermin D (GSDMD)-dependent pathway. The pyroptotic cell death is accompanied necrosis and immunogenic (ICD) simultaneously for efficient situ immunity initiation. Meanwhile, carbonyl cyanide m-chlorophenyl hydrazone (CCCP), mitochondrial depolarizing agent, successfully loaded into NPs found to further enhance process. Collectively, obtained Pluronic F127-modified CCCP-incorporated (F127 ZIF-8CCCP NPs) activate antitumor reprogram immunosuppressive microenvironment (TME), realizing high-efficiency growth inhibition. This work will facilitate biomedicine applications of provide good inspiration pyroptosis-induced cancer therapy.

Язык: Английский

Процитировано

205

Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy DOI Creative Commons
Qiang Lü,

Dongquan Kou,

Shenghan Lou

и другие.

Journal of Hematology & Oncology, Год журнала: 2024, Номер 17(1)

Опубликована: Апрель 2, 2024

Abstract Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in clinical delivery of immunomodulatory compounds. The tumor microenvironment (TME), comprising macrophages, fibroblasts, immune cells, plays a crucial role response modulation. Nanoparticles, engineered to reshape TME, shown promising results enhancing by facilitating targeted These nanoparticles can suppress fibroblast activation, promote M1 macrophage polarization, aid dendritic cell maturation, encourage T infiltration. Biomimetic further enhance increasing internalization agents cells such as cells. Moreover, exosomes, whether naturally secreted body or bioengineered, been explored regulate TME immune-related affect cancer immunotherapy. Stimuli-responsive nanocarriers, activated pH, redox, light conditions, exhibit potential accelerate co-application with checkpoint inhibitors is an emerging strategy boost anti-tumor immunity. With their ability induce long-term immunity, nanoarchitectures are structures development. This review underscores critical overcoming current driving advancement modification.

Язык: Английский

Процитировано

161

Biodegradable Ca2+ Nanomodulators Activate Pyroptosis through Mitochondrial Ca2+ Overload for Cancer Immunotherapy DOI
Pan Zheng, Binbin Ding, Guo‐Qing Zhu

и другие.

Angewandte Chemie International Edition, Год журнала: 2022, Номер 61(36)

Опубликована: Июнь 10, 2022

Abstract Pyroptosis provides a new direction and broad prospects for cancer immunotherapy. However, the development of nanoplatform as pyroptosis inducer is limited, discovery type nano‐pyroptosis immunotherapy still imminent. Herein, biodegradable Ca 2+ nanomodulators (CaNMs) are prepared inducers via mitochondrial overload. The obtained CaNMs can decompose under low pH to release curcumin, leading sudden surge in ions, eventually resulting pyroptosis. We not only confirm occurrence overload‐triggered first time but also reveal robust immune responses CaNMs, along with remarkably suppressing tumor proliferation lung metastasis. This work will provide strategies inspiration pyroptosis‐mediated treatments, greatly contributing further nanomodulators.

Язык: Английский

Процитировано

157

Bioactive inorganic nanomaterials for cancer theranostics DOI
Zifan Pei,

Huali Lei,

Liang Cheng

и другие.

Chemical Society Reviews, Год журнала: 2023, Номер 52(6), С. 2031 - 2081

Опубликована: Янв. 1, 2023

Bioactive materials are a special class of biomaterials that can react in vivo to induce biological response or regulate functions, thus achieving better curative effect than traditional inert biomaterials. For cancer theranostics, compared with organic polymer nanomaterials, inorganic nanomaterials possess unique physical and chemical properties, have stronger mechanical stability on the basis maintaining certain bioactivity, easy be compounded various carriers (polymer carriers, etc.), so as achieve specific antitumor efficacy. After entering nanoscale, due nano-size effect, high surface area nanostructures, exhibit effects, which significantly influence interaction organisms. Therefore, research applications bioactive theranostics attracted wide attention. In this review, we mainly summarize recent progress also introduce definition, synthesis modification strategies nanomaterials. Thereafter, tumor imaging therapy, including microenvironment (TME) regulation, catalytic gas regulatory cell death immunotherapy, discussed. Finally, biosafety challenges mentioned, their future development opportunities prospected. This review highlights bioapplication

Язык: Английский

Процитировано

137

Recent progress of metal‐based nanomaterials with anti‐tumor biological effects for enhanced cancer therapy DOI Creative Commons

Huali Lei,

Zifan Pei, Chenyu Jiang

и другие.

Exploration, Год журнала: 2023, Номер 3(5)

Опубликована: Июнь 30, 2023

Abstract Metal‐based nanomaterials have attracted broad attention recently due to their unique biological physical and chemical properties after entering tumor cells, namely effects. In particular, the abilities of Ca 2+ modulate T cell receptors activation, K + regulate stem differentiation, Mn activate STING pathway, Fe 2+/3+ induce ferroptosis enhance catalytic therapy, make metal ions metal‐based play crucial roles in cancer treatments. Therefore, superior advantages characteristics microenvironment, we will summarize recent progress anti‐tumor effects nanomaterials. Based on different this review mainly focuses following five aspects: (1) metal‐enhanced radiotherapy sensitization, (2) (3) ferroptosis, (4) pyroptosis, (5) immunotherapy. At same time, shortcomings therapy are also discussed, future research directions been prospected. The highlights promising biosafety, potent efficacy for in‐depth various mechanism studies provide novel ideas application

Язык: Английский

Процитировано

101

Surface modified lanthanide upconversion nanoparticles for drug delivery, cellular uptake mechanism, and current challenges in NIR-driven therapies DOI
Anees A. Ansari, Abdul K. Parchur, Guanying Chen

и другие.

Coordination Chemistry Reviews, Год журнала: 2022, Номер 457, С. 214423 - 214423

Опубликована: Янв. 31, 2022

Язык: Английский

Процитировано

92

State of the art advancements in sonodynamic therapy (SDT): Metal-Organic frameworks for SDT DOI

Zuoxiu Xiao,

Qiaohui Chen, Yuqi Yang

и другие.

Chemical Engineering Journal, Год журнала: 2022, Номер 449, С. 137889 - 137889

Опубликована: Июль 4, 2022

Язык: Английский

Процитировано

76

Sodium Bicarbonate Nanoparticles for Amplified Cancer Immunotherapy by Inducing Pyroptosis and Regulating Lactic Acid Metabolism DOI
Binbin Ding, Pan Zheng, Jia Tan

и другие.

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(40)

Опубликована: Авг. 17, 2023

Abstract Although immunotherapy has a broad clinical application prospect, it is still hindered by low immune responses and immunosuppressive tumor microenvironment. Herein, simple drug‐free inorganic nanomaterial, alkalescent sodium bicarbonate nanoparticles (NaHCO 3 NPs), prepared via fast microemulsion method for amplified cancer immunotherapy. The obtained NaHCO regulates lactic acid metabolism through acid‐base neutralization so as to reverse the mildly acidic environment. Additionally, can further release high amounts of Na + ions inside cells induce surge in intracellular osmolarity, thus activate pyroptosis pathway immunogenic cell death (ICD), damage‐associated molecular patterns (DAMPs) inflammatory factors, improve responses. Collectively, NPs observably inhibit primary/distal growth metastasis remitted immunosuppression induced activation, showing an enhanced antitumor immunity efficiency. This work provides new paradigm mediated treatment, which potential

Язык: Английский

Процитировано

64

Interrelation between Programmed Cell Death and Immunogenic Cell Death: Take Antitumor Nanodrug as an Example DOI
Qi Meng, Binbin Ding,

Ping’an Ma

и другие.

Small Methods, Год журнала: 2023, Номер 7(5)

Опубликована: Янв. 27, 2023

Abstract Programmed cell death (PCD, mainly including apoptosis, necrosis, ferroptosis, pyroptosis, and autophagy) immunogenic (ICD), as important mechanisms, are widely reported in cancer therapy, understanding the relationship between two is significant for clinical tumor treatments. Considering that vast nanodrugs developed to induce PCD ICD simultaneously, this review, interrelationship described using nanomedicines examples. First, an overview of patterns focus on morphological differences interconnections among them provided. Then apoptosis terms endoplasmic reticulum stress by introducing various treatments recent developments with inducible immunogenicity. Next, crosstalk non‐apoptotic (including signaling pathways introduced their through examples further illustrated. Finally, its application prospects development new nanomaterials summarized. This review believed deepen ICD, extend biomedical applications nanodrugs, promote progress therapy.

Язык: Английский

Процитировано

51