Doxorubicin prodrug-based nanomedicines for the treatment of cancer

European Journal of Medicinal Chemistry, Год журнала: 2023, Номер 258, С. 115612 - 115612

Опубликована: Июль 5, 2023

Язык: Английский

---

Spleen-selective co-delivery of mRNA and TLR4 agonist-loaded LNPs for synergistic immunostimulation and Th1 immune responses

Journal of Controlled Release, Год журнала: 2023, Номер 357, С. 133 - 148

Опубликована: Март 29, 2023

Язык: Английский

---

Hyaluronan-decorated copper-doxorubicin-anlotinib nanoconjugate for targeted synergistic chemo/chemodynamic/antiangiogenic tritherapy against hepatocellular carcinoma

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 662, С. 857 - 869

Опубликована: Фев. 11, 2024

Язык: Английский

---

Nanotechnology-based drug delivery for breast cancer treatment: Current applications and future directions

European Journal of Medicinal Chemistry Reports, Год журнала: 2025, Номер unknown, С. 100268 - 100268

Опубликована: Апрель 1, 2025

Язык: Английский

---

Albumin is a reliable drug-delivering molecule: Highlighting points in cancer therapy

Medicine in Drug Discovery, Год журнала: 2024, Номер 22, С. 100186 - 100186

Опубликована: Март 28, 2024

As the most abundant protein in blood, albumin binds and transports hydrophilic, hydrophobic, lipophilic molecules required for growth development of cells tissues. Due to surface location charged groups inner hydrophobic site, it proteins, peptides, amino acids, fatty nutrients, other biomolecules. It is a multi-domain involved various functions including contribution oncotic pressure. Because its unique sequence structure, can be efficiently utilized develop drug delivery systems against diseases, cancer. protein, rich both negative positive charges on surface, attracts great attention discipline. Inner sites were proven an efficient delivering drugs. Albumin binding domains, widely distributed among receptors matricellular molecules, ease penetration into cells. A high ratio cysteine provides stability molecule causes thiol-disulfide interactions, which play essential role release. In this work, we highlighted several points nature as drug-carrying regarding biochemical physical properties: self-assembling, formation covalent bonds, situ corona, etc. Research publications searched NCBI database by keywords related sections/subsections review topic. Tens research works have been dedicated enhancing therapeutic efficacy anticancer drugs using last two decades contributed clarifying mechanistic action albumin. We discussed mechanisms first section. another section, reviewed enhanced antitumor/anticancer efficacies those fabricated DDSs terms contribution. The results vitro vivo experiments merged that section consisting subsections individual means. Clinical trials three separate approaches used enhance albumin-based final devoted strategies could significantly improve cancer delivery.

Язык: Английский

---

Paclitaxel prodrug nanoparticles boost antitumor efficacy via hitchhiking of human serum albumin

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 679, С. 144 - 154

Опубликована: Окт. 16, 2024

Язык: Английский

---

Balancing efficacy and safety of doxorubicin-loaded albumin nanoparticles utilizing pH-sensitive doxorubicin-fatty acid prodrugs

Nano Research, Год журнала: 2024, Номер 17(6), С. 5491 - 5500

Опубликована: Фев. 29, 2024

Язык: Английский

---

Protein-nanoparticle co-assembly supraparticles for drug delivery: Ultrahigh drug loading and colloidal stability, and instant and complete lysosomal drug release

International Journal of Pharmaceutics, Год журнала: 2024, Номер 658, С. 124231 - 124231

Опубликована: Май 15, 2024

Язык: Английский

---

Thermal effects and drugs competition on the palmitate binding capacity of human serum albumin

Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 722, С. 150168 - 150168

Опубликована: Май 23, 2024

Human serum albumin (HSA) is the most abundant plasma protein of circulatory system. It a multidomain, multifunctional that, combining diverse affinities and wide specificity, binds, stores, transports variety biological compounds, pharmacores, fatty acids. HSA finding increasing uses in drug-delivery due to its ability carry functionalized ligands prodrugs. All this raises question competition for binding sites occupancy case multiple ligands, which turn influences structure/dynamic/function relationship also has an impact on biomedical applications. In work, effects interactive palmitic acid (PA), warfarin (War) ibuprofen (Ibu) thermal stability were studied using DSC, ATR-FTIR, EPR. PA high-affinity physiological ligand, while two drugs are widely used their anticoagulant anti-inflammatory efficacy, exogenous compounds that accommodate deputed drug site DS1 DS2, respectively overlapping with some sites. The results indicate acquires highest when it fully saturated PA. ligand does not hamper War or Ibu native state protein. addition, three bind simultaneously, suggesting synergic cooperative influence allosteric effects. increased subsequent binary moderates aggregation propensity restricts dynamics. biophysics findings provide interesting features about stability, aggregation, dynamics interaction relevant drug-delivery.

Язык: Английский

---

Cisplatin-loaded mesoporous polydopamine nanoparticles capped with MnO2 and coated with platelet membrane provide synergistic anti-tumor therapy

International Journal of Pharmaceutics, Год журнала: 2024, Номер 656, С. 124093 - 124093

Опубликована: Апрель 6, 2024

Язык: Английский

---