ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 18, 2025
Diabetic
wounds
are
blocked
in
the
inflammatory
stage,
growth
factors
degraded,
and
blood
vessels
difficult
to
regenerate,
leading
continuous
necrosis
nonhealing
of
wound.
Hydrogen
sulfide
(H2S)
plays
an
important
role
pathophysiological
process
wound
healing
has
a
long
history
treating
skin
diseases.
Although
salt
solution
is
preferred
donor
exogenous
H2S,
its
rapid
release
rate,
excess
production,
difficulty
accurately
controlling
dose
limit
use.
Herein,
we
developed
H2S
sustained-release
nanospheres
NaHS@MS@LP
for
treatment
diabetic
wounds.
nanosphere
was
composed
NaHS-loaded
mesoporous
silicon
core
DSPE-PEG
liposome
outer
membrane.
When
were
used
treat
rats,
delivered
into
cells
loaded
NaHS
slowly
released
through
hydrolysis,
participating
all
stages
healing.
In
conclusion,
regulated
microenvironment
by
inducing
transformation
macrophages
M2
type
promoted
angiogenesis
collagen
deposition
accelerate
rats.
Our
findings
provide
strategies
chronic
wounds,
including
but
not
limited
Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 9, 2025
With
the
dilemma
of
limited
efficacy
individual
therapies,
it
is
crucial
to
develop
innovative
combination
therapy
systems
target
complex
pathogenesis
cancer.
In
this
study,
we
designed
a
nanoprodrug
ISL@MIL-101-ADT
facilitate
synergistic
delivery
hydrogen
sulfide
(H2S)
and
prodrug
ISL
for
specific
eradication
tumor
cells
with
minimal
toxicity
maximal
efficacy.
The
passively
targeted
tumors
through
enhanced
permeation
retention
effects,
followed
by
disintegration
release
IR780,
lonidamine
(LND),
H2S.
IR780
localizes
LND
mitochondria
enhance
therapeutic
effects
turn
on
phototherapy
chemotherapy
when
exposed
laser;
H2S
inhibits
procancer
signaling
pathways
mitochondrial
function.
vivo
experiments
have
demonstrated
that
exhibits
excellent
pharmacokinetic
properties
significant
inhibitory
effects.
Additionally,
possesses
outstanding
photothermal
fluorescence
imaging
capabilities.
Therefore,
strongly
believe
present
herein
holds
great
potential
application
in
cancer
therapy.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 7, 2025
Abstract
Chronic
wounds
are
a
common
complication
of
diabetes,
causing
significant
inconvenience,
persistent
pain,
and
economic
burden
to
patients.
Real‐time
monitoring
wound
status
timely
treatment
with
intelligent
dressings
is
promising
way
treat
infection
accelerate
healing.
However,
the
traditional
make
it
difficult
simultaneously
maintain
true
state
meet
dynamic
needs
chronic
wounds.
Herein,
multifunctional
self‐powered
patch
(MSPP)
featured
antibacterial,
hypoglycemic,
electrical
stimulation
designed
promote
healing
real‐time
status,
in
which
laser‐induced
nanozyme
electrodes
prepared
situ
through
laser
scanning
technology
construct
highly
stable
nanozyme‐based
glucose
biofuel
cells
(GBFCs).
Enzymatic
cascade
reaction
GBFCs
can
use
local
hyperglycemia
produce
reactive
oxygen
species
effective
antibacterial
properties,
reduce
while
generating
microcurrent,
further
diabetes
In
just
10
days,
patch‐treated
group
achieves
100%
shrinkage.
Meanwhile,
pH
sensing
module
MSPP
also
monitor
fluctuations
correct
test
results,
improving
accuracy.
brief,
construction
provides
solutions
for
developing
closed‐loop
biomedical
systems
that
integrate
monitoring,
diagnosis,
treatment.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 23, 2024
Abstract
Diabetic
wounds
are
a
major
devastating
complication
of
diabetes
due
to
hyperglycemia,
bacterial
invasion,
and
persistent
inflammation,
the
current
antibiotic
treatments
can
lead
emergence
multidrug‐resistant
bacteria.
Herein,
bimetallic
nanozyme‐based
biomimetic
bio‐cocklebur
(GNR@CeO
2
@GNPs)
is
designed
synthesized
for
diabetic
wound
management
by
depositing
spiky
ceria
(CeO
)
shells
gold
nanoparticles
(GNPs)
on
nanorod
(GNR)
nanoantenna.
The
plasmonic‐enhanced
nanozyme
catalysis
self‐cascade
reaction
properties
simultaneously
boost
two‐step
enzyme‐mimicking
catalytic
activity
GNR@CeO
@GNPs,
leading
significant
improvement
in
overall
therapeutic
efficacy
rather
than
mere
additive
effects.
Under
glucose
activation
808
nm
laser
irradiation,
@GNPs
material
captures
photons
promotes
transfer
hot
electrons
from
GNR
GNPs
into
CeO
,
realizing
“butterfly
effect”
consuming
local
glucose,
overcoming
limited
antibacterial
efficiency
an
individual
PTT
modality,
providing
substantial
reactive
oxygen
species.
In
vitro
vivo
experiments
demonstrate
material's
exceptional
antibiofilm
against
Gram‐negative
Gram‐positive
bacteria,
which
reduce
promote
collagen
deposition,
facilitate
angiogenesis,
thereby
accelerating
healing.
This
study
provides
promising
new
strategy
develop
nanozymes
with
cascade
mode
antibiotic‐free
synergistic
treatment
infected
wounds.
Journal of Tissue Engineering,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 1, 2024
The
rising
prevalence
of
diabetes
has
underscored
concerns
surrounding
diabetic
wounds
and
their
potential
to
induce
disability.
intricate
healing
mechanisms
are
multifaceted,
influenced
by
ambient
microenvironment,
including
prolonged
hyperglycemia,
severe
infection,
inflammation,
elevated
levels
reactive
oxygen
species
(ROS),
ischemia,
impaired
vascularization,
altered
wound
physicochemical
properties.
In
recent
years,
hydrogels
have
emerged
as
promising
candidates
for
treatment
owing
exceptional
biocompatibility
resemblance
the
extracellular
matrix
(ECM)
through
a
three-dimensional
(3D)
porous
network.
This
review
will
first
summarize
microenvironment
alterations
occurring
in
wounds,
aiming
provide
comprehensive
understanding
its
pathogenesis,
then
classification
recently
developed
be
presented,
encompassing
properties
such
hypoglycemic
effects,
anti-inflammatory
capabilities,
antibacterial
attributes,
ROS
scavenging
abilities,
promotion
angiogenesis,
pH
responsiveness,
more.
primary
objective
is
offer
valuable
reference
repairing
based
on
unique
microenvironment.
Moreover,
this
paper
outlines
avenues
future
advancements
hydrogel
dressings
facilitate
expedite
process
wounds.
ACS Applied Engineering Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 31, 2024
Constitutionally
isomeric
peptides
are
a
class
of
molecules
with
the
same
composition
but
different
connections,
ultimately
exhibiting
significant
variation
in
properties.
In
this
review,
we
survey
recent
advances
rational
design
constitutionally
and
preparation
discrete
assemblies.
Then,
examine
their
applications
as
templates
for
inorganic
nanoparticle
growth,
biofilm
elimination,
or
carriers
on-demand
gas/drug
delivery.
At
end,
both
future
outlooks
upcoming
challenges
emerging
research
topic
also
discussed.
It
is
our
hope
that
review
will
give
insight
into
how
subtle
modulation
peptide
sequence
would
generate
dramatic
change
resultant
property.
