Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 3, 2024
Abstract
Inflammatory
bowel
disease
(IBD)
is
an
idiopathic
gastrointestinal
with
drastically
increasing
incidence
rates.
Due
to
its
multifactorial
etiology,
a
precise
investigation
of
the
pathogenesis
extremely
difficult.
Although
reductionist
cell
culture
models
and
more
complex
in
animals
have
clarified
understanding
individual
mechanisms
contributing
factors
IBD
past,
it
remains
challenging
bridge
research
clinical
practice.
Conventional
2D
cannot
replicate
host–microbiota
interactions
stable
long‐term
microbial
culture.
Further,
extrapolating
data
from
animal
patients
due
genetic
environmental
diversity
leading
differences
immune
responses.
Human
intestine
organ‐on‐chip
(OoC)
emerged
as
alternative
vitro
model
approach
investigate
IBD.
OoC
not
only
recapitulate
human
intestinal
microenvironment
accurately
than
cultures
yet
may
also
be
advantageous
for
identification
important
disease‐driving
pharmacological
interventions
targets
possibility
emulating
different
complexities.
The
predispositions
biological
hallmarks
focusing
on
at
mucosal
barrier
are
elucidated
here.
Additionally,
potential
OoCs
explore
microbiota‐related
therapies
personalized
medicine
treatment
discussed.
Current Opinion in Endocrinology Diabetes and Obesity,
Год журнала:
2024,
Номер
31(3), С. 122 - 130
Опубликована: Апрель 8, 2024
This
review
critically
examines
interconnected
health
domains
like
gut
microbiome,
bone
health,
interleukins,
chronic
periodontitis,
and
coronavirus
disease
2019
(COVID-19),
offering
insights
into
fundamental
mechanisms
clinical
implications,
contributing
significantly
to
healthcare
biomedical
research.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(27), С. 15092 - 15105
Опубликована: Июнь 26, 2024
Probiotics
are
indispensable
for
maintaining
the
structure
of
gut
microbiota
and
promoting
human
health,
yet
their
survivability
is
frequently
compromised
by
environmental
stressors
such
as
temperature
fluctuations,
pH
variations,
mechanical
agitation.
In
response
to
these
challenges,
microfluidic
technology
emerges
a
promising
avenue.
This
comprehensive
review
delves
into
utilization
encapsulation
delivery
probiotics
within
gastrointestinal
tract,
with
focus
on
mitigating
obstacles
associated
probiotic
viability.
Initially,
it
elucidates
design
application
devices,
providing
precise
platform
encapsulation.
Moreover,
scrutinizes
carriers
fabricated
through
including
emulsions,
microspheres,
gels,
nanofibers,
intent
bolstering
stability.
Subsequently,
assesses
efficacy
methodologies
in
vitro
simulations
vivo
experimentation,
underscoring
potential
amplifying
efficiency
health
outcomes.
sum,
represents
pioneering
approach
stabilization,
offering
avenues
cater
consumer
preferences
diverse
array
functional
food
options.
The
human
microbiome
is
vital
for
health.
Droplet
microfluidics
offers
a
versatile
toolbox
research,
enabling
single-cell
sequencing,
cultivation,
and
functional
analyses
to
deepen
our
understanding
drive
innovations.
Comprehensive Reviews in Food Science and Food Safety,
Год журнала:
2024,
Номер
23(5)
Опубликована: Авг. 13, 2024
The
demand
for
functional
food
is
rising
in
tandem
with
the
prevalence
of
chronic
diseases.
Probiotics
play
a
crucial
role
development,
yet
their
ability
to
confer
health
benefits
host
remains
topic
debate
according
Food
and
Agriculture
Organization/World
Health
Organization
requirements.
application
culturomics,
innovative
isolation
techniques,
within
realm
probiotics
increasingly
deemed
essential
fully
harnessing
latent
potential
microbial
reservoirs.
Nevertheless,
its
confined
predominantly
human
fecal
sources.
Following
integration
probiogenomics,
significant
advancements
have
been
made
safety
assessment
probiotics.
However,
adoption
novel
probiotic
microorganisms
has
match
requisite
pace.
Progress
research
concerning
host-probiotic
interactions
by
employing
omics
technologies,
particularly
animal
models,
notable.
Nonetheless,
comprehensive
elucidation
mechanisms
action
trial
studies
are
lagging
behind.
Additionally,
viability
probiotics,
spanning
from
production
as
foods
transit
colon,
markedly
improved
through
encapsulation
techniques.
opportunities
exploration
persist
regarding
alternative
coating
materials
diverse
methodologies.
Furthermore,
there
discernible
transition
domain
probiotic-based
foods,
shifting
away
primarily
dairy-centric
focus
toward
inclusion
broader
array
categories.
This
review
addresses
critical
issues
ranging
sources
techniques
final
developments.
while
doing
so,
it
explores
probiogenomics
applications
characterization,
investigations
into
interactions,
strategies
stabilization
under
harsh
environmental
conditions.
Biosensors,
Год журнала:
2024,
Номер
14(9), С. 449 - 449
Опубликована: Сен. 19, 2024
Gastrointestinal
cell
culture
technology
has
evolved
in
the
past
decade
with
integration
of
microfluidic
technologies,
bringing
advantages
greater
selectivity
and
cost
effectiveness.
Herein,
these
technologies
are
sorted
into
three
categories,
namely
cell-culture
insert
devices,
conventional
3D-printed
devices.
Each
category
is
discussed
brief
improvements
also
here.
Introduction
different
companies
applications
derived
from
each
provided
to
encourage
uptake.
Subsequently,
future
perspectives
integrating
microfluidics
trending
topics
like
stool-derived
vitro
communities
gut-immune-tumor
axis
investigations
discussed.
Insights
on
modular
its
implications
gastrointestinal
cultures
Future
point-of-care
(POC)
relations
devices
In
conclusion,
this
review
presents
an
introduction
platform
insight
contribution
cultures.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 10, 2025
Radiation
colitis
is
an
inflammatory
response
induced
by
damage
to
colonic
tissue
from
radiation
therapy
that
primarily
affects
patients
undergoing
abdominal
or
pelvic
treatments.
In
this
study,
we
designed
a
selenium-loaded
probiotic
(EcN-Se@SA)
encapsulated
in
sodium
alginate
gel
for
the
oral
treatment
of
colitis.
Selenium
nanoparticles
(Se
NPs)
exhibit
antioxidant,
anti-inflammatory,
ferroptosis,
and
repair-promoting
properties.
To
enhance
therapeutic
efficacy
Se
NPs
radiation-induced
colitis,
combined
with
Escherichia
coli
Nissle
1917
them
hydrogel.
The
resulting
EcN-Se@SA
formulation
not
only
withstands
gastric
acid
intestinal
fluids
but
also
remains
colon
cecum
extended
periods.
Oral
administration
attenuates
X-ray-induced
mice
through
its
antioxidant
anti-inflammatory
effects,
macrophage
reprogramming,
inhibition
ferroptosis
histiocytes.
This
work
introduces
promising
candidate
