A tensegrity-based mechanochemical model for capturing cell oscillation and reorientation DOI Creative Commons
Weihua Zhou, Xu Yin, Shejuan Xie

и другие.

Journal of Applied Physics, Год журнала: 2024, Номер 136(7)

Опубликована: Авг. 16, 2024

The cytoskeleton, a dynamic network of structural proteins within cells, is essential for cellular deformation and responds to external mechanical cues. Here, based on the structure combined with biochemical reactions activator RhoA inhibitor F-actin, we develop novel mechanochemical cytoskeleton model investigate behavior cells. Interestingly, find that active stress fibers exhibit diverse dynamical modes at specific concentration thresholds. existence differences sustained feedback in activators inhibitors trigger global oscillation isolated In addition, under uniaxial biaxial stretches, preferentially diffuse toward more significantly deformed cytoskeletal elements, their interactions regulate cell align main stretching direction. Our findings, consistent many experimental results, provide fundamental insights into remodeling mechanosensing mechanisms.

Язык: Английский

Simultaneous manipulation of elastic and acoustic waves in acousto-elastic metamaterial beams DOI

Chang Fu,

Xiaolei Tang, Ying Liu

и другие.

Extreme Mechanics Letters, Год журнала: 2025, Номер unknown, С. 102286 - 102286

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Spontaneous oscillation in collective microswimmers: Insights from a chiral self-propelled rod model DOI
Shuangquan He, Xu Yin,

Dong Liang

и другие.

Physical review. E, Год журнала: 2025, Номер 111(1)

Опубликована: Янв. 13, 2025

Active systems exhibit fascinating self-organized structures and rich motility patterns, yet the underlying mechanisms governing their emergence characteristics remain elusive. Here, we develop a chiral self-propelled rod (CSPR) model with mechanical contact-induced quorum sensing to investigate spatiotemporal dynamics of dense bacteria populations. Our findings show that CSPR showcases spontaneous nonequilibrium oscillatory clustering active systems. The motion these clusters depend on colony features (microswimmers' morphology density) (polarization alignment angular velocity CSPR). Interestingly, reinforced strength polar accelerates formation stable oscillations, while decreased density modify pattern. Significantly, our study identifies three distinct oscillation patterns: global oscillation, bistable multistable reveals phase transitions are driven by variations in spatial correlation CSPR. These insights provide new perspective understanding intricate evolution matter, opening possible avenues for emerging applications.

Язык: Английский

Процитировано

0
Fluidization and anomalous density fluctuations in 2D Voronoi cell tissues with pulsating activity DOI Creative Commons

Zhu-Qin Li,

Qun‐Li Lei,

Yu‐qiang Ma

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2025, Номер 122(10)

Опубликована: Март 5, 2025

Cells not only can be motile by crawling but are also capable of nonmotility active motions like periodic contraction or pulsation. In this work, based on a Voronoi cell model, we show how activity affects the structure, dynamic, and density fluctuations cellular monolayers. Our model shows that random pulsation fluidizes solid epithelial tissues into hyperuniform fluid state, while synchronization inhibits fluidity causes reverse solidification. results indicate solidification is Berezinskii-Kosterlitz-Thouless-type transition, characterized strong density/dynamic heterogeneity arising from annihilation topological defects in pulsating phase space. The magnitude length scale diverge with period, resulting an opposite giant fluctuation anti-hyperuniformity. We propose fluctuating hydrodynamic theory unify two anomalous phenomena. findings help to understand recent experimental observations Madin-Darby canine kidney

Язык: Английский

Процитировано

0
Designing hydrogel dimensionality to investigate mechanobiology DOI
Marine Luciano, Sylvain Gabriele

Soft Matter, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This review highlights innovative hydrogel platforms—from 2D to 3D, including 2.5D and sandwich systems—that reveal how mechanical cues regulate cell behavior, with translational potential in tissue engineering disease modeling.

Язык: Английский

Процитировано

0
Local Mechanical Modulation-Driven Evagination in Invaginated Epithelia DOI
Yin Xu,

Dong Liang,

Shuang-Quan He

и другие.

Nano Letters, Год журнала: 2024, Номер 24(23), С. 7069 - 7076

Опубликована: Май 29, 2024

Local cells can actively create reverse bending (evagination) in invaginated epithelia, which plays a crucial role the formation of elaborate organisms. However, precise physical mechanism driving evagination remains elusive. Here, we present three-dimensional vertex model, incorporating intrinsic cell polarity, to explore complex morphogenesis induced by local mechanical modulations. We find that tissues spontaneously generate due shift apicobasal polarity. Their exact shapes be analytically determined differential tension and internal stress. Our continuum theory exhibits three regions phase diagram controlled these two parameters, showing curvature transitions from ordered disordered states. Additionally, delve into epithelial transition nucleus repositioning, revealing its active contribution force generation. The uncovered principles could potentially guide more studies on folding diverse systems.

Язык: Английский

Процитировано

2
The Cellular Potts Model on Disordered Lattices DOI Creative Commons
Hossein Nemati, Joost de Graaf

Soft Matter, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

The cellular Potts model, also known as the Glazier-Graner-Hogeweg is a lattice-based approach by which biological tissues at level of individual cells can be numerically studied. Traditionally, square or hexagonal underlying lattice structure assumed for two-dimensional systems, and this to introduce artifacts in dynamics model tissues. That is, on regular lattices, assume shapes that are dictated symmetries lattice. Here, we developed variant method applied broad class (ir)regular lattices. We show an irregular deriving from fluid-like configuration, two types removed. further report transition between disordered solid-like hexagonally ordered phase present monodisperse confluent function their surface tension. This shows hallmarks first-order different glass/jamming transitions commonly reported vertex active Voronoi models. emphasize analyzing distribution shape parameters found our state space. Our analysis provides useful reference future study epithelia using model.

Язык: Английский

Процитировано

1
Hybrid Materials for Vascular Applications: A Preliminary In Vitro Assessment DOI Creative Commons
Martina Todesco, Martina Casarin,

Deborah Sandrin

и другие.

Bioengineering, Год журнала: 2024, Номер 11(5), С. 436 - 436

Опубликована: Апрель 28, 2024

The production of biomedical devices able to appropriately interact with the biological environment is still a great challenge. Synthetic materials are often employed, but they fail replicate and functional properties native tissues, leading variety adverse effects. Several commercial products based on chemically treated xenogeneic tissues: their principal drawback due weak mechanical stability low durability. Recently, decellularization has been proposed bypass drawbacks both synthetic materials. Acellular can integrate host tissues avoiding/mitigating any foreign body response, lack sufficient patency impermeability. present paper investigates an innovative approach realization hybrid that combine decellularized bovine pericardium polycarbonate urethanes. These benefit from superior biocompatibility tissue polymers. They were assessed physicochemical, structural, mechanical, points view; ability promote cell growth was also investigated. polymer appeared well adhere each other, two sides distinguishable. maximum elongation mainly affected by pericardium, which allows for lower than polymer; this latter, in turn, influenced strength achieved. results confirmed promising features vascular grafts be repopulated circulating cells, thus, improving blood compatibility.

Язык: Английский

Процитировано

0
Mechanochemical patterning and wave propagation in multicellular tubes DOI

Pengyu Yu,

Bo Li

Journal of the Mechanics and Physics of Solids, Год журнала: 2024, Номер 192, С. 105801 - 105801

Опубликована: Июль 30, 2024

Язык: Английский

Процитировано

0
A tensegrity-based mechanochemical model for capturing cell oscillation and reorientation DOI Creative Commons
Weihua Zhou, Xu Yin, Shejuan Xie

и другие.

Journal of Applied Physics, Год журнала: 2024, Номер 136(7)

Опубликована: Авг. 16, 2024

The cytoskeleton, a dynamic network of structural proteins within cells, is essential for cellular deformation and responds to external mechanical cues. Here, based on the structure combined with biochemical reactions activator RhoA inhibitor F-actin, we develop novel mechanochemical cytoskeleton model investigate behavior cells. Interestingly, find that active stress fibers exhibit diverse dynamical modes at specific concentration thresholds. existence differences sustained feedback in activators inhibitors trigger global oscillation isolated In addition, under uniaxial biaxial stretches, preferentially diffuse toward more significantly deformed cytoskeletal elements, their interactions regulate cell align main stretching direction. Our findings, consistent many experimental results, provide fundamental insights into remodeling mechanosensing mechanisms.

Язык: Английский

Процитировано

0