Aging, Год журнала: 2024, Номер unknown
Опубликована: Окт. 17, 2024
Precursor T-cell acute lymphoblastic leukemia (Pre-T ALL) is a malignant neoplastic disease in which T-cells proliferate the bone marrow. Single-cell sequencing technology could identify characteristic cell types, facilitating study of therapeutic mechanisms Pre-T ALL.
Язык: Английский
Nano Letters, Год журнала: 2024, Номер 24(25), С. 7698 - 7705
Опубликована: Июнь 13, 2024
Highly efficient recognition of cancer cells by immune is important for successful therapeutic-cell-based immunotherapy. Herein, we present a facile NIR-II nanoadaptor [hyaluronic acid (HA)/dibenzocyclooctyne (DBCO)-Au:Ag2Te quantum dots (QDs)] enhancing the tumor and binding ability natural killer (NK) via bio-orthogonal click reaction in vivo. The Nanoadaptor possesses superior tumor-targeting capacity, facilitating accumulation chemical receptor DBCO at sites. Subsequently, enrichment on cell surfaces provides multivalent sites capturing pretreated azide engineered NK92 (NK92-N3) through an reaction, thereby significantly therapeutical efficiency. dynamic process nanoadaptor-mediated NK to could be vividly observed using multiplexed fluorescence imaging mouse model lung cancer. Such strategy can extended other therapeutic cellular systems holds promise future clinical applications.
Язык: Английский
Процитировано
4
Current Oncology, Год журнала: 2025, Номер 32(2), С. 79 - 79
Опубликована: Янв. 30, 2025
Chimeric antigen receptor (CAR)-T cell therapy yields good results in the treatment of various hematologic malignancies. However, efficacy CAR-T against solid tumors has proven to be limited, primarily because tumor-associated extracellular matrix (ECM) creates an intractable barrier for cytotoxic cells that are supposed kill cancer cells. This review unravels multifaceted role ECM impeding infiltration, survival, and functions within tumors. We analyze situations when intratumoral limits by being a purely physical complicates lymphocyte penetration/migration also acts as immunosuppressive factor impairs antitumor activities In addition, we highlight promising approaches such engineering with improved capabilities penetrate migrate into/through ECM, combination therapies aimed at attenuating high density potential others enable overcoming ECM-related obstacles. A detailed overview data relevant studies not only helps better understand interactions between but outlines ways more effectively use
Язык: Английский
Процитировано
0
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Фев. 23, 2025
Chimeric antigen receptor (CAR)-T cells have shown unparalleled efficacy in treating hematologic cancers, but their application solid tumor treatment remains challenging due to the immunosuppressive microenvironment (TME). It is highly significant develop safe and efficient TME regulatory strategies for adoptive cellular immunotherapy of tumors. Herein, a TME-responsive nanoimmunomodulator (FMANAC) designed using multicomponent coordination self-assembly method reconstruct immune chemokine gradient overcome suppression CAR-T cell immunoactivity, thereby improving infiltration killing efficiency within The acidic induces disassembly FMANAC, followed by drug release, which C–C ligand 5 (CCL5) improves disrupted chemotactic tumors, increasing recruitment into deep tissue; NLG919 reverses indoleamine 2,3-dioxygenase (IDO)-mediated immunosuppression create favorable environment exert function. In H460 lung cancer animal model, this nanoregulatory strategy combined with engineered CD276 cells, guided multiplexed near-infrared-II fluorescence imaging programmed administration, achieved significantly enhanced efficacy.
Язык: Английский
Процитировано
0
Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113745 - 113745
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101782 - 101782
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Molecular Biomedicine, Год журнала: 2024, Номер 5(1)
Опубликована: Дек. 16, 2024
Abstract Cancer, characterized by its immune evasion, active metabolism, and heightened proliferation, comprises both stroma cells. Although the research has always focused on parenchymal cells, non-parenchymal components must not be overlooked. Targeting cancer cells proven to a formidable challenge, yielding limited success broad scale. The tumor microenvironment(TME), critical niche for cell survival, presents novel way treatment. Cancer-associated fibroblast (CAF), as main component of TME, is dynamically evolving, dual-functioning stromal cell. Furthermore, their biological activities span entire spectrum development, metastasis, drug resistance, prognosis. A thorough understanding CAFs functions therapeutic advances holds significant clinical implications. In this review, we underscore heterogeneity elaborating origins, types function. Most importantly, elucidating direct or indirect crosstalk between extracellular matrix, emphasize tumorigenicity in cancer. Finally, highlight challenges encountered exploration list targeted therapies CAF, which have implications
Язык: Английский
Процитировано
2
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Окт. 13, 2024
Abstract Pancreatic cancer is a malignancy tumor with luxuriant extracellular matrix (ECM) and highly immunosuppressive microenvironment its therapy remains an enormous challenge. A two‐step targeting‐tunable strategy proposed for orthotopic pancreatic via designing semiconducting nanoswitches (C/SPN T /αP) to amplify the mitochondrion damage programmed death ligand 1 (PD‐L1) blockade. mitochondrion‐targeting small nanoparticle (SPN ) consisting of mitochondrial targeting moiety triphenylphosphine (TPP) polymer embedded PD‐L1 antibody (αPD‐L1) into sono‐responsive collagen binding peptide (CBP)‐conjugated nanoliposomes form C/SPN /αP. In first step, /αP achieve ECM observably increase their enrichment sites because CBP can effectively bind in ECM. Upon ultrasound (US) irradiation, mediate structural failure sonodynamic effect on‐demand releases SPN αPD‐L1. second target mitochondria induce under US irradiation triggering amplified cell apoptosis immunogenic (ICD). Moreover, released αPD‐L1 blocks pathway further boost immunological effect. Such novel therapeutic regimen almost completely eradicate Panc02 KPC tumors mouse models. This study presents nanomedicine treatments deep‐seated tumors.
Язык: Английский
Процитировано
1
Annals of Pancreatic Disorders and Treatment, Год журнала: 2024, Номер 6(1), С. 001 - 005
Опубликована: Апрель 6, 2024
Pancreatic cancer, which is regarded as the third deadliest cancer globally, poses a significant challenge because of its limited range treatment options and high mortality rate. Currently, there focus on both development novel concept in vaccine designing parallel study associated immune mechanisms. To further our understanding healthcare field, variety promising designs have been introduced for in-depth study. The were developed to include mKRAS-specific amphiphile vaccine, targets specific mutation KRAS gene addition multi-antigen targeted DNA aims stimulate an response against multiple antigens. Furthermore, later vaccines based peptide-based vaccines, mRNA-based cell-based engineered bacterial vectors using oral Salmonella-based vaccine. presents new discusses up-to-date immunological manifestations these designed vaccines.
Язык: Английский
Процитировано
0
Chemosensors, Год журнала: 2024, Номер 12(6), С. 113 - 113
Опубликована: Июнь 16, 2024
Tumors represent a significant threat to human health, underscoring the critical need for effective treatment strategies. However, conventional drug therapies are hampered by imprecise delivery, potentially leading inadequate efficacy and severe side effects. The strategic development of nanomedicines is believed harbor enormous potential enhancing safety efficacy, especially precise, tumor-targeted therapies. Nevertheless, fate these within body intricately governed various physiological barriers complex environments, posing challenges predicting their behaviors. Near-infrared II (NIR-II, 1000–1700 nm) fluorescence imaging technology serves as non-invasive, real-time monitoring method that can be applied precise evaluation nanomedicine delivery in cancer therapy due its numerous advantages, including high tissue penetration depth, spatiotemporal resolution, signal-to-noise ratio. In this review, we comprehensively summarize pivotal role NIR-II guiding intratumoral shed light on current applications, challenges, promising prospects field.
Язык: Английский
Процитировано
0
Aging, Год журнала: 2024, Номер unknown
Опубликована: Окт. 17, 2024
Precursor T-cell acute lymphoblastic leukemia (Pre-T ALL) is a malignant neoplastic disease in which T-cells proliferate the bone marrow. Single-cell sequencing technology could identify characteristic cell types, facilitating study of therapeutic mechanisms Pre-T ALL.
Язык: Английский
Процитировано
0