Bioconjugate Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 17, 2024
Currently,
pulmonary
complications
such
as
lung
infections
during
the
perioperative
period
are
still
main
cause
of
prolonged
hospitalization
and
death
in
patients
with
injury
due
to
lack
effective
drugs.
Clusterzyme,
a
kind
artificial
enzyme
high
enzyme-like
activity
safety
profile,
exhibits
good
effects
on
reducing
oxidative
stress
immunomodulation.
Here,
we
present
functionalized
patches
that
is
administered
airways
rescues
injured
organ
via
clusterzymes.
The
long-term
antioxidant
capacity
significantly
ameliorated
lipopolysaccharide-induced
function
impairment
significant
reduction
goblet
cell
metaplasia
stress.
inflammatory
factors
cytokines
interleukin-1β,
interleukin-6,
tumor
necrosis
factor-α
levels
decreased
by
50%,
while
mtDNA
copy
number
increased
50%
ATP
production
100%.
Mice
was
improved,
suggesting
can
rescue
modulating
immune
responses
well
protecting
mitochondria,
providing
an
avenue
for
intervention
injury.
Nano Letters,
Год журнала:
2024,
Номер
24(37), С. 11697 - 11705
Опубликована: Сен. 3, 2024
Osteoarthritis
(OA)
is
a
degenerative
joint
disease
characterized
by
obscure
etiology
and
unsatisfactory
therapeutic
outcomes,
making
the
development
of
new
efficient
therapies
urgent.
Superfluous
reactive
oxygen
species
(ROS)
have
historically
been
considered
one
crucial
factors
inducing
pathological
progression
OA.
Ultrasmall
Prussian
blue
nanoparticles
(USPBNPs),
approximately
sub-5
nm
in
size,
are
developed
regulating
configuration
polyvinylpyrrolidone
chains.
USPBNPs
display
an
excellent
ROS
eliminating
capacity
catalase-like
activity,
capable
decomposing
hydrogen
peroxide
(H
Molecules,
Год журнала:
2024,
Номер
29(14), С. 3339 - 3339
Опубликована: Июль 16, 2024
Signal
transduction
and
homeostasis
are
regulated
by
complex
protein
interactions
in
the
intracellular
environment.
Therefore,
transportation
of
impermeable
macromolecules
(nucleic
acids,
proteins,
drugs)
that
control
is
essential
for
modulating
cell
functions
therapeutic
applications.
However,
macromolecule
across
membrane
not
easy
because
separates
intra/extracellular
environments,
types
molecular
proteins.
Cell-penetrating
peptides
(CPPs)
expected
to
be
carriers
transport.
CPPs
can
transport
into
cells
through
endocytosis
direct
translocation.
The
mechanism
remains
largely
unclear
owing
several
possibilities.
In
this
review,
we
describe
methods
investigating
CPP
conformation,
translocation,
cargo
using
artificial
membranes.
We
also
investigated
biomolecular
living
membranes
via
CPPs.
Subsequently,
show
only
biochemical
applications
but
synthetic
biological
Finally,
recent
progress
biomolecule
nanoparticle
specific
tissues
described
from
viewpoint
drug
delivery.
This
review
provides
opportunity
discuss
these
two
platforms.
