Hypoxia-induced
tumor
metastasis
severely
hinders
the
efficacy
of
photodynamic
therapy
(PDT)
in
cancer
treatment.
Current
strategies
predominantly
offer
palliative
suppression
HIF-1α
pathway,
emphasizing
urgent
need
for
innovative
PDT
approaches
to
prevent
from
outset.
Our
study
revealed
that
typical
triggers
an
increase
cytoplasmic
Ca2+
levels,
activating
HIF-1α,
and
reducing
levels
can,
turn,
mitigate
metastasis.
Considering
cytoplasm's
role
storage
regulation,
we
propose
PDT-induced
can
be
addressed
at
its
source
by
precise
intracellular
localization
photosensitizers
(PSs).
We
developed
near-infrared
(NIR)
cyanine
PSs
with
inherent
nucleus
targeting
capabilities.
These
effectively
inhibit
elevation
reduce
activity
upon
irradiation,
achieving
remarkable
antimetastatic
effects
4T1
tumors.
Consequently,
our
findings
highlight
pivotal
provide
a
robust
approach
circumventing
outset
using
new
nucleus-targeting
organic
PSs.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 14, 2025
Alveolar
echinococcosis
(AE)
is
a
serious
parasitic
infectious
disease
that
highly
invasive
and
destructive
to
the
liver
has
high
mortality
rate.
However,
currently,
there
no
effective
targeted
imaging
treatment
method
for
precise
detection
therapy
of
AE.
We
proposed
new
two-step
targeting
strategy
(TSTS)
AE
based
on
poly(lactic-co-glycolic
acid)
(PLGA).
designed
constructed
novel
type
ICG@PLGA@Lips
nanoprobe
with
integrated
properties.
First,
we
used
characteristics
PLGA
gluconeogenic
raw
material
target
during
blood
circulation.
Then,
utilized
specifically
penetrating
shell
achieve
specific
identification
in
liver.
Under
808
nm
laser
excitation,
effectively
achieved
accurate
near-infrared
II
(NIR-II,
900-1700
nm)
fluorescence
methods
through
PDT
effects.
improved
optical
properties
ICG,
while
liposomes
further
biocompatibility
nanoprobe.
As
showed
strong
NIR-II
emission
good
biocompatibility,
advantages
navigation
surgical
resection
lesions.
Thus,
assistance
ICG@PLGA@Lips,
real-time
first
time.
successfully
obtained
vivo
imaging-guided
photodynamic/surgical
This
TSTS-based
exploration
provided
early
AE,
which
expected
significantly
improve
prognosis
patients.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 3, 2025
Abstract
Organic
semiconducting
small
molecules
that
simultaneously
possess
NIR‐IIb
(1500–1700
nm)
fluorescence
imaging
(FLI),
hypoxia‐tolerant
photodynamic
therapy
(PDT)
as
well
photothermal
(PTT)
abilities
activated
by
a
single
NIR‐II
(1000‐1700
light
can
achieve
high‐performance
deep‐tissue
phototheranostics,
but
have
not
gain
much
attention.
Herein,
novel
organic
molecule
(DTT)
with
an
absorption
maximum
at
844
nm
and
emission
944
in
its
monomer
state
is
synthesized
through
delicate
molecular
design.
Surprisingly,
the
spectrum
of
DTT
extend
into
region.
Subsequently,
phototheranostic
nanoparticles
(DTT
NPs)
dramatically
red‐shifted
absorption/emission
peak
(1029/1128
are
skillfully
developed
based
on
J
‐aggregation
strategy,
which
show
greatly
high
molar
absorptivity
Upon
1064
excitation,
resolution
FLI
be
achieved
whole‐body
vessels,
cerebral
vasculatures,
tumors
living
mice
treated
NPs.
Moreover,
NPs
also
produce
type‐I
reactive
oxygen
species
hyperthermia
under
laser
irradiation
for
oxygen‐less‐dependent
PDT
PTT
combination
therapy,
eventually
achieving
efficient
antitumor
effects.
This
work
provides
facile
strategy
designing
high‐efficiency
phototheranostics.
Abstract
Photodynamic
therapy
(PDT)
represents
a
high‐efficient
and
non‐invasive
therapeutic
modality
for
current
future
tumor
treatments,
drawing
extensive
attention
in
the
fields
of
antitumor
drug
clinical
phototherapy.
In
recent
years,
photosensitizer
(PS)
market
PDT
applications
have
expanded
to
address
various
cancers
skin
diseases.
However,
hypoxic
environment
within
tumors
poses
substantial
challenge
capability
reactive
oxygen
species‐dependent
PDT.
Consequently,
researches
increasingly
focus
from
type
II
I
mechanism,
which
relies
on
radical
production
with
less
or
no
dependence.
Despite
significant
progress
development
PSs,
holistic
understanding
regarding
design
principles
these
molecules
remains
elusive.
Specifically,
electron
transfer‐mediated
are
extensively
studied
years
but
is
insufficiently
addressed
existing
reviews.
This
review
systematically
summarizes
advancements
molecular
rationales
organic
categorizing
them
into
three
key
fundamental
strategies:
modulating
PS
charge
distribution,
singlet
forbidden
via
low
triplet
excited
state,
accelerating
formation
inducing
transfer.
aims
offer
valuable
insights
advancement
anti‐hypoxia
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 6, 2025
Abstract
Integrating
imaging
guided
therapy
and
therapeutic
effect
self‐reporting
would
highly
benefit
clinic
applications.
J
‐type
aggregates
of
organic
dyes
with
corresponding
photothermal
have
made
them
popular
agents
for
photoacoustic
(PA)
(PTT).
However,
approaches
to
manipulate
the
disaggregation
‐aggregate
dye
fluorescence
recovery
rarely
been
reported,
which
limits
full
exploration
in
Herein,
indocyanine
green
(ICG)
is
designed
a
micelle
structure
(
‐ICG‐Micelle)
by
co‐assembling
ICG
DSPE‐Pep‐PEG,
contains
peptide
KADEVDAC
that
recognized
cleaved
caspase‐3.
Taking
advantages
red‐shifted
absorbance
‐ICG‐Micelle,
it
achieves
PA
navigated
delivery
process
an
indication
tumor
accumulation
time
position
perform
PTT.
Corresponding
cell
apoptosis
caspase‐3
generation
cleaves
results
ICG,
self‐reports
real
time,
intensity
demonstrates
similar
tendency
as
H&E
staining
at
sections.
The
as‐presented
‐ICG‐Micelle
promising
contribution
precise
cancer
therapy.
