Inducers of Autophagy and Cell Death: Focus on Copper Metabolism

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 290, С. 117725 - 117725

Опубликована: Янв. 1, 2025

Язык: Английский

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Recent advances in chemodynamic nanotherapeutics to overcome multidrug resistance in cancers

Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 184, С. 117901 - 117901

Опубликована: Фев. 11, 2025

Язык: Английский

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“Mix‐and‐Match”: Self‐Sorting Assembly Governed Supramolecular Polymeric Nanomedicine for Boosting Combined Chemo/Phototherapy

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Abstract Precise cancer nanomedicine requires rational molecular instructions of therapeutic agents. Harnessing the structure‐property‐function relationships represents a practical strategy toward smart and effective nanomedicine. A structurally novel hydrogen‐bonded (H‐bonded) supramolecular nanoformulation generated by orthogonal self‐sorting assembly chemo‐prodrug (FPtF) phototherapeutics (BPeB) is here reported, to reach an autonomous with improved anti‐tumor efficacy combining chemo/phototherapy (CT/PT). The high‐fidelity H‐bonding modularity from privileged heterocomplementary diaminopyridine/5‐fluorouracil (DAP/FU) Hamilton wedge/barbiturate (HW/Ba) pairs, respectively enable precise spatial control binding interactions FPtF BPeB, in turn allowing process specific “mix‐and‐match” capability. To directly stimulate phototherapy BPeB via near‐infrared (NIR) light, spectral matched upconversion nanoparticles (UCNPs, β‐NaYF 4 :Yb,Er) are encapsulated simultaneously. As result, polymeric nanomicelles, i.e., F/B/U@PHDO, readily fabricated. Moreover, distinct association constant (Ka) DAP/FU (≈10 2 M −1 ) HW/Ba 4‐5 pairs reflect different strengths stabilities H‐bonds, thus endowing programmable dissociation, accompanied release through pH/thermal‐stimuli. Therapeutic regime appreciated outcomes ultimately accomplished combined CT/PT. opportunities offered design anticipated point new paradigm for therapy.

Язык: Английский

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Core-Shell Nanoconstructs for Cancer-Based Biomedical Applications

Опубликована: Янв. 1, 2025

Язык: Английский

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The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

Abstract Ferroptosis, as novel type of regulated cell death that has garnered widespread attention over the past decade, witnessed continuous discovery an increasing number regulatory mechanisms. Trace metal elements play a multifaceted and crucial role in oncology. Interestingly, it been increasingly evident these elements, such copper, are involved regulation iron accumulation, lipid peroxidation antiferroptotic systems, suggesting existence “nonferrous” mechanisms ferroptosis. In this review, comprehensive overview composition mechanism ferroptosis is provided. The interaction between copper metabolism (including cuproptosis) cancer, well roles other trace (such zinc, manganese, cobalt, molybdenum) specifically focused. Furthermore, applications nanomaterials based on metals cancer therapy also reviewed potential strategies for co‐targeting cuproptosis explored. Nevertheless, light intricate ambiguous nature interactions, ongoing research essential to further elucidate ferroptosis, thereby facilitating development therapeutic targets approaches treatment.

Язык: Английский

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Bimetallic nanoreactor mediates cascade amplification of oxidative stress for complementary chemodynamic-immunotherapy of tumor

Biomaterials, Год журнала: 2024, Номер 317, С. 123075 - 123075

Опубликована: Дек. 31, 2024

Язык: Английский

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