Nano Energy, Год журнала: 2024, Номер unknown, С. 110618 - 110618
Опубликована: Дек. 1, 2024
Язык: Английский
Biomaterials, Год журнала: 2025, Номер 318, С. 123113 - 123113
Опубликована: Янв. 17, 2025
Язык: Английский
Процитировано
2
Chinese Science Bulletin (Chinese Version), Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 111059 - 111059
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1
Dyes and Pigments, Год журнала: 2025, Номер unknown, С. 112663 - 112663
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Фев. 13, 2025
Photothermal therapy (PTT), a popular local treatment that uses heat to ablate tumors, has limited efficacy in addressing metastatic and deeply located tumors when used alone. Integrating PTT with immunotherapy not only yields synergistic effect but also promotes cancer regression confers the benefit of immune memory, which can surmount challenges faced by isolation. Metal-based nanomaterials, renowned for their superior photothermal conversion efficiency distinctive photochemical properties, have been extensively researched applied field PTT. This review summarizes latest developments combination therapies, specific focus on checkpoint (ICT) treatment, including comprehensive overview recent advancements noble metal-based 2D transition metal chalcogenides (TMDCs)-based agents, anticancer combining blockades (anti-CTLA-4 anti-PD-L1) therapy. The goal this is present an application, current future prospects agents combined ICT treatment.
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Фев. 14, 2025
Abstract Piezoelectric semiconductor nanomaterials have attracted considerable interest in piezocatalytic tumor treatment. However, therapy encounters obstacles such as suboptimal piezoelectric responses, rapid electron‐hole recombination, inefficient energy harvesting, and the complexities of microenvironment. In this study, sulfur vacancy‐engineered cobalt (Co) single‐atom doped molybdenum disulfide (SA‐Co@MoS 2 ) nanoflowers are strategically designed, which exhibit enhanced effects. Specifically, introduction Co single atom not only induces lattice distortion out‐of‐plane polarization but also leads to formation numerous vacancies. These changes collectively narrow intrinsic bandgap material, facilitating effective separation migration charge carriers, enabling efficient production reactive oxygen species under ultrasound stimulation. Additionally, SA‐Co@MoS demonstrate improved enzymatic activity glutathione depletion capabilities attributed mixed valence states Co, intensifying oxidative stress cells, leading cell cycle arrest apoptosis, while inactivation peroxidase 4 ferroptosis. Both vitro vivo results indicate that can significantly eliminate cells. This study offers valuable insights into exploration doping‐enhanced sonosensitizers for cancer treatment, potentially paving way advancements field synergistic enzyodynamic therapy.
Язык: Английский
Процитировано
0
Pharmaceutics, Год журнала: 2025, Номер 17(4), С. 409 - 409
Опубликована: Март 25, 2025
Colorectal cancer poses a significant threat to human health due its high aggressiveness and poor prognosis. Key factors impacting patient outcomes include post-surgical recurrence, chemotherapeutic drug resistance, insensitivity immunotherapy. Consequently, early diagnosis the development of effective targeted therapies are essential for improving prevention treatment strategies. Inorganic nanomaterials have gained prominence in colorectal owing their unique size, advantageous properties, modifiability. Various types inorganic nanomaterials—such as metal-based, metal oxide, quantum dots, magnetic nanoparticles, carbon-based, rare-earth nanomaterials—have demonstrated potential enhancing multimodal imaging, delivery, synergistic therapies. These advancements underscore critical role therapeutic outcomes. This review highlights properties nanomaterials, summarizes recent applications progress treatment, discusses challenges translating these materials into clinical use. It aims provide valuable insights future research application management.
Язык: Английский
Процитировано
0
Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Март 26, 2025
The advancement of mitochondria-targeted near-infrared-II (NIR-II) excitable phototheranostics constitutes a promising strategy for improving fluorescence-image-guided cancer phototherapy. However, developing phototheranostic agents that simultaneously combine high-contrast NIR-II fluorescence imaging with effective multimodal therapeutic techniques remains substantial challenge. Herein, we reported shielding-donor-acceptor-donor-shielding structured (FCD-T) by molecular engineering strategy, followed self-assembly glutathione-responsive copolymer to form FCD-T nanoparticles. introduction functional bithiophene endows significant electron-donating properties and reduces intermolecular π-π stacking interactions. robust π-conjugation fluorene good rigidity would enhance the intramolecular charge transfer capability. Therefore, NPs exhibited an absorption peak at 1075 nm emission 1280 nm. Upon light excitation, such nanoparticles could generate excellent photothermal photodynamic performances biocompatibility. Moreover, phototherapy further facilitated mitochondrial apoptosis-related pathways, activating antitumor immunity inhibiting tumor growth single irradiation low doses.
Язык: Английский
Процитировано
0
Applied Surface Science, Год журнала: 2025, Номер unknown, С. 163491 - 163491
Опубликована: Май 1, 2025
Процитировано
0
Journal of Colloid and Interface Science, Год журнала: 2025, Номер 696, С. 137854 - 137854
Опубликована: Май 10, 2025
Язык: Английский
Процитировано
0