Advancing CNS Therapeutics: Enhancing Neurological Disorders with Nanoparticle-Based Gene and Enzyme Replacement Therapies
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 1443 - 1490
Опубликована: Фев. 1, 2025
Abstract:
Given
the
complexity
of
central
nervous
system
(CNS)
and
diversity
neurological
conditions,
increasing
prevalence
disorders
poses
a
significant
challenge
to
modern
medicine.
These
disorders,
ranging
from
neurodegenerative
diseases
psychiatric
not
only
impact
individuals
but
also
place
substantial
burden
on
healthcare
systems
society.
A
major
obstacle
in
treating
these
conditions
is
blood-brain
barrier
(BBB),
which
restricts
passage
therapeutic
agents
brain.
Nanotechnology,
particularly
use
nanoparticles
(NPs),
offers
promising
solution
this
challenge.
NPs
possess
unique
properties
such
as
small
size,
large
surface
area,
modifiable
characteristics,
enabling
them
cross
BBB
deliver
drugs
directly
affected
brain
regions.
This
review
focuses
application
gene
therapy
enzyme
replacement
(ERT)
for
disorders.
Gene
involves
altering
or
manipulating
expression
can
be
enhanced
by
designed
carry
various
genetic
materials.
Similarly,
improve
efficacy
ERT
lysosomal
storage
(LSDs)
facilitating
delivery
brain,
overcoming
issues
like
immunogenicity
instability.
Taken
together,
explores
potential
revolutionizing
treatment
options
highlighting
their
advantages
future
directions
rapidly
evolving
field.
Keywords:
system,
nanoparticle,
therapy,
Язык: Английский
Current landscape of metal–organic framework-mediated nucleic acid delivery and therapeutics
International Journal of Pharmaceutics,
Год журнала:
2025,
Номер
unknown, С. 125295 - 125295
Опубликована: Фев. 1, 2025
Язык: Английский
Natural Bioactive Compounds Solanesol and Chlorogenic Acid Assembled Nanomicelles for Alzheimer’s Disease Therapy
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 25, 2025
Solanesol
(Sol)
and
chlorogenic
acid
(CHA)
are
naturally
active
compounds.
Sol
exhibits
a
significant
free
radical
absorption
ability
strong
antioxidant
activity.
CHA,
typical
phenolic
acid,
excellent
anticancer,
anti-inflammation,
antibacterial
properties.
Herein,
bifunctional
nanomicelles
(CI@SPK)
were
skillfully
designed
to
take
advantage
of
the
unique
properties
CHA
treat
Alzheimer's
disease
(AD).
Hydrophobic
was
modified
with
poly(ethylene
glycol)
self-assemble
into
stable
(SP).
could
be
encapsulated
hydrophobic
core
these
nanomicelles,
which
increased
its
bioavailability
greatly.
Short
peptide
K
(CKLVFFAED)
incorporated
facilitate
their
crossing
blood-brain
barrier.
Then,
CI@SPK
targeted
AD
lesion
area,
released
in
greater
quantities
help
IR780
under
irradiation
an
808
nm
laser,
resulting
synergistically
scavenging
reactive
oxygen
species
(ROS)
Sol.
Consequently,
demonstrated
capabilities
ROS,
inhibiting
β-amyloid
(Aβ)
aggregation,
eventually
modulating
microglia
phenotype
from
M1
M2
promote
Aβ
phagocytosis
clearance.
In
vivo
studies
indicated
that
improved
learning
cognitive
impairments
APP/PS1
mice
by
reducing
plaque
inflammation,
signifying
potential
value
clinical
application
for
treatment.
Язык: Английский
Polydopamine Powered Droplet Electricity Generator for Protein Assay with CRISPR/Cas Enabled Amplification
Nano Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 7, 2025
Protein
function
investigation
and
clinical
assay
are
fundamental
to
modern
biology
medical
diagnostics.
Flap
endonuclease
1
(FEN1),
a
key
enzyme
in
DNA
replication
repair,
plays
critical
role
the
progression
of
many
diseases.
Taking
FEN1
as
an
example,
we
present
novel
protein
detection
platform
combining
triboelectric
nanogenerator
(TENG)
CRISPR/Cas
technologies.
As
specific
form
TENG,
transistor-droplet
electricity
generator
(TDEG)
is
explored,
which
offers
low-cost,
simple
fabrication
approach
with
real-time
capability.
Meanwhile,
activated
system
catalyzes
reactions
on
three-dimensional
tetrahedron
interface,
promising
high
sensitivity.
This
work
not
only
demonstrates
powerful
method
for
rapid
but
also
pioneers
integration
TENG.
It
has
great
prospect
future
development
TENG
sensors.
Язык: Английский
Jahn–Teller-Driven Electronic Modulation of Bio-Heterojunction for Wound Regeneration after Postoperative Tumor Resection
Nano Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 12, 2025
Abundant
·OH,
1O2,
and
·O2-
provide
an
efficient
methodology
for
rapid
tumor
bacteria
killing,
whereas
a
limitation
focuses
on
the
catalytic
efficiency.
Thus,
Jahn-Teller-driven
electronic
modulation
of
bioheterojunction
(bioHJ)
platform
is
developed
remedy
in
diabetic
infectious
wound
regeneration
after
postoperative
resection.
The
bioHJ
composed
MoTe2/MnO2
glucose
oxidase
(GOx).
GOx
depletes
to
H2O2,
which
intercepts
their
metabolism.
H2O2
can
be
further
converted
into
highly
lethal
·OH
owing
peroxidase-mimetic
activity
via
Jahn-Teller
effect,
while
GSH
consumed
due
its
GPx-mimetic
activity.
Both
amplified
upon
NIR
irradiation
as
NIR-activatable
enzyme-mimetic
activities.
In
vivo
studies
subcutaneous
model
authenticate
ability
kill
tumor,
defeat
bacterial
infection,
accelerate
regeneration.
This
work
enlightens
powerful
resection
using
engineered
bioHJ.
Язык: Английский
Biomass spinach-drived metal-free carbon dots-based nanozyme for multimodal nitrite sensing and functionalized by glucose oxidase as ROS amplifiers to enhance tumor therapy
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
304, С. 140875 - 140875
Опубликована: Фев. 10, 2025
Язык: Английский
ROS-related nanoparticles for the management of Alzheimer’s disease: Wielding the double-edged sword
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 161784 - 161784
Опубликована: Март 1, 2025
Язык: Английский
Metal-organic framework mimetic enzymes: Exploring new horizons in brain chemistry
Chinese Chemical Letters,
Год журнала:
2024,
Номер
unknown, С. 110652 - 110652
Опубликована: Ноя. 1, 2024
Язык: Английский
Gold Nanoparticles Decorated CoAl LDH Monolayer: A Peroxidase-Like Nanozyme for Sensitive Colorimetric Detection of Acetylcholinesterase and Inhibitors
Inorganic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 9, 2024
Monitoring
acetylcholinesterase
(AChE)
activity
and
its
inhibitor
is
crucial
yet
challenging
for
the
early
diagnosis
treatment
of
neurological
diseases.
In
this
study,
we
present
Au
nanoparticle
decorated
CoAl
layered
double
hydroxide
monolayer
(Au@CoAl-LDH-m)
as
a
peroxidase-like
(POD)
nanozyme
sensitive
colorimetric
detection
AChE
inhibitor,
thiamine
pyrophosphate
(TPP).
Remarkably,
Au@CoAl-LDH-m
can
catalyze
oxidation
chromogenic
substrates
through
POD-like
activity,
which
effectively
inhibited
by
thiocholine
(TCh,
catalytic
product
AChE),
thereby
enabling
TPP
visible
readout.
The
approach
provides
highly
specificity
assay
with
broader
linear
response
range
(1-100
mU
mL
Язык: Английский