Alzheimer’s, Parkinson’s, Frontotemporal Lobar Degeneration, and Amyotrophic Lateral Sclerosis Start in Pediatric Ages: Ultrafine Particulate Matter and Industrial Nanoparticles Are Key in the Early-Onset Neurodegeneration: Time to Invest in Preventive Medicine
Toxics,
Год журнала:
2025,
Номер
13(3), С. 178 - 178
Опубликована: Фев. 28, 2025
Billions
of
people
are
exposed
to
fine
particulate
matter
(PM2.5)
levels
above
the
USEPA’s
annual
standard
9
μg/m3.
Common
emission
sources
anthropogenic,
producing
complex
aerosolized
toxins.
Ultrafine
(UFPM)
and
industrial
nanoparticles
(NPs)
have
major
detrimental
effects
on
brain,
but
USA
does
not
measure
UFPM
a
routine
basis.
This
review
focuses
development
progression
common
neurodegenerative
diseases,
as
diagnosed
through
neuropathology,
among
young
residents
in
Metropolitan
Mexico
City
(MMC).
MMC
is
one
most
polluted
megacities
world,
with
population
22
million
residents,
many
whom
unaware
brain
caused
by
their
atmosphere.
Fatal
diseases
(such
Alzheimer’s
Parkinson’s)
that
begin
childhood
populations
living
air
environments
preventable.
We
conclude
UFPM/NPs
capable
disrupting
neural
homeostasis
give
rise
relentless
processes
throughout
entire
life
highly
MMC.
The
paradigm
reaching
old
age
neurodegeneration
no
longer
supported.
Neurodegenerative
changes
start
early
pediatric
ages
irreversible.
It
time
invest
preventive
medicine.
Язык: Английский
A Practical Spectroscopic Protocol Based on Sialic Acid‐S‐Protein Interaction for SARS‐CoV‐2 Detection
ChemistrySelect,
Год журнала:
2024,
Номер
9(47)
Опубликована: Дек. 1, 2024
Abstract
This
work
aims
to
investigate
the
possible
role
of
sialic
acids
as
host
cell
receptors
for
SARS‐CoV‐2
infection
and
hence
develop
a
practical
spectroscopic
protocol
that
relies
on
interaction
between
fetuin
spike
protein
(S‐protein)
detection.
For
purpose,
firstly,
synthesized
gold
nanoparticles
(AuNPs)
were
functionalized
with
fetuin.
Then,
AuNPs
incubated
S‐protein
difference
in
absorbance
value
at
530
nm
was
measured
spectroscopically.
The
characterized
by
using
fourier
transform
infrared
spectroscopy
atomic
force
microscopy
methods
whereas
sole
AuNP
structure
investigated
transmission
electron
technique.
experimental
parameters
such
amount
(0,
5,
10,
20
µg/mL)
incubation
duration
20,
30,
40
min)
optimized
analytical
characteristics
developed
biosensors
investigated.
detection
limit
calculated
2.40
ng/mL,
linear
range
4.98
95.2
relative
standard
deviation
0.72%
9.95
ng/mL
S‐protein.
Finally,
biosensor
applied
real
samples
taken
from
non‐infected
infected
individuals.
Язык: Английский