Injectable dual-network hydrogel for phototherapy and immunomodulation in the treatment of MRSA-infected and diabetic wound

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 163026 - 163026

Опубликована: Апрель 1, 2025

Язык: Английский

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In situ microneedle-based system with “Tripartite Delivery” characteristics for local antisense oligonucleotide therapy in acute bacterial infections

Nano Today, Год журнала: 2025, Номер 64, С. 102780 - 102780

Опубликована: Май 7, 2025

Язык: Английский

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Thienoacene-Based Conjugated Oligoelectrolytes for Membrane-Targeting Antimicrobial Approaches: Synergistic Biofilm Eradication and Antimicrobial Resistance Reversal

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Май 25, 2025

Membrane-targeting antimicrobials represent a promising class of materials to combat the escalating issue antimicrobial resistance. Herein, we report series membrane-targeting conjugated oligoelectrolytes (COE-nT) featuring thienoacene moieties as π-conjugated cores, designed for tackling COE-nT exhibited higher activity against Gram-positive bacteria compared Gram-negative bacteria, with no intrinsic resistance observed in either drug-resistant strain. Notably, reduction length correlated an increase membrane permeability and toxicity toward cells animals. Moreover, demonstrated synergistic effects commercial antibiotics strains restored susceptibility ribosome-targeting antibiotics, such clindamycin erythromycin. To illustrate their potential, combination COE-4T mupirocin was employed treat methicillin-resistant Staphylococcus aureus infections murine wound model, resulting significant biofilm eradication enhanced efficacy. This new thienoacene-based COEs expands library defined structure-activity relationship profiles demonstrates its potential powerful adjunctive therapy overcoming

Язык: Английский

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Applications of In-Situ formed Hydrogels in Flexible Wearable Sensors

Material Sciences, Год журнала: 2025, Номер 15(05), С. 1123 - 1130

Опубликована: Янв. 1, 2025

Язык: Английский

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