ICG‐Conjugated and ¹²⁵I‐Labeled Polymeric Micelles with High Biosafety for Multimodality Imaging‐Guided Photothermal Therapy of Tumors

Advanced Healthcare Materials, Год журнала: 2020, Номер 9(5)

Опубликована: Янв. 28, 2020

Noninvasive multimodality imaging-guided precision photothermal therapy (PTT) is proven to be an effective strategy for tumor theranostics by integrating diagnostics and therapeutics in one nanoplatform. In this study, indocyanine green (ICG)-conjugated radionuclide iodine-125 (

Язык: Английский

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Double Switch Biodegradable Porous Hollow Trinickel Monophosphide Nanospheres for Multimodal Imaging Guided Photothermal Therapy

Nano Letters, Год журнала: 2019, Номер 19(8), С. 5093 - 5101

Опубликована: Июнь 27, 2019

Due to the limitation of inorganic nanomaterials in present clinical applications induced by their inherent nonbiodegradability and latent long-term side effects, we successfully prepared double switch degradable clearable trinickel monophosphide porous hollow nanospheres (NiP PHNPs) modified with bovine serum albumin (BSA). Attributed acidic oxidative degradation capacities, NiP PHNPs can be effectively excreted from mice without toxicity. Moreover, because paramagnetic high molar extinction coefficient property resulting strong absorption second near-infrared light (NIR II) biowindow, have potential used for photoacoustic imaging (PAI) T1-weighted magnetic resonance (MRI) guided photothermal ablation tumors NIR II biowindow. Specifically, it is interesting that structure enable act as intelligent drug carriers an on-demand release ability. These findings highlight great cancer theranostics field inspire us further broaden bioapplications transition metal phosphides.

Язык: Английский

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Stimulus-Responsive Nanomedicines for Disease Diagnosis and Treatment

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(17), С. 6380 - 6380

Опубликована: Сен. 2, 2020

Stimulus-responsive drug delivery systems generally aim to release the active pharmaceutical ingredient (API) in response specific conditions and have recently been explored for disease treatments. These approaches can also be extended molecular imaging report on diagnosis management. The stimuli used activation are based differences between environment of diseased or targeted sites, normal tissues. Endogenous include pH, redox reactions, enzymatic activity, temperature others. Exogenous site-specific use magnetic fields, light, ultrasound endogenous exogenous lead structural changes cleavage cargo carrier, leading API. A wide variety stimulus-responsive developed-responsive both a single stimulus multiple stimuli-and represent theranostic tool treatment. In this review, commonly development nanoplatforms enumerated. An emphasis chemical structure property relationships is provided, aiming focus insights design systems. Several examples applications these nanomedicines discussed.

Язык: Английский

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Lanthanide-Doped Bi₂SiO₅@SiO₂ Core–Shell Upconverting Nanoparticles for Stable Ratiometric Optical Thermometry

ACS Applied Nano Materials, Год журнала: 2020, Номер 3(3), С. 2594 - 2604

Опубликована: Фев. 12, 2020

The development of nanomaterials with high sensitivity to external stimuli such as temperature is critical investigate the driving force not only biological processes but also catalytic mechanisms in extreme environments. However, instability nano-objects at temperatures and different environments a serious drawback limiting often their real use. This particularly severe case bismuth-based compounds, making highly stable nanosystems challenge. Here, we report synthesis uniform crystalline lanthanide-doped Bi2SiO5 nanoparticles into silica shell controlled thickness (Bi2SiO5:Ln@SiO2) for design reliable ratiometric optical thermometer acid fine control SiO2 modeled based on theoretical experimental approach. formation single phase triggered by local reactivity between Bi2O3 Bi2O3@SiO2 system, leading double-layered Bi2SiO5@SiO2 hollow nanosystem. potential Bi2SiO5:Ln@SiO2 nanosystem nanothermometer demonstrated upconverting Yb–Er couple. performances were evaluated wide range linearity Boltzmann law (280–800 K) showing suitable values relative sensitivity, uncertainty, repeatability (R > 99%) applications probe In fact, strategy results an acid-inert thermal up pH < 1 overcoming weakness materials promising properties situ thermometry reactions.

Язык: Английский

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Tumor-Microenvironment-Induced All-in-One Nanoplatform for Multimodal Imaging-Guided Chemical and Photothermal Therapy of Cancer

ACS Applied Materials & Interfaces, Год журнала: 2019, Номер 11(28), С. 25043 - 25053

Опубликована: Июнь 20, 2019

Precisely locating tumor site based on tumor-microenvironment-induced (TMI) multimodal imaging is especially interesting for accurate and efficient cancer therapy. In the present investigation, a novel TMI all-in-one nanoplatform, CuSNC@DOX@MnO2-NS, has been successfully fabricated chemical photothermal (Chem-PTT) therapy guided by site. Here, CuS nanocages with mesoporous hollow structure (CuSNC) acting as nanocarriers provide high capacity loading anticancer drug, doxorubicin (DOX). The outer layer of MnO2 nanoshell (MnO2-NS) acts "gatekeeper" to control DOX release until nanoplatform arrives at site, where abundant glutathione H+ decompose MnO2-NS into paramagnetic Mn2+. magnetic resonance fluorescent were then triggered locate tumor, which was further improved account intrinsic property CuSNC. Guided multimode imaging, combination upon CuSNC exhibits eminent efficiency ablation. biocompatibility avoid unwanted harm normal tissues during trans-shipment in body. investigation thus develops cost-effective facile preparations easy integration Chem-PTT treatment capabilities potential application precise

Язык: Английский

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