Biocatalytic and Antioxidant Nanostructures for ROS Scavenging and Biotherapeutics

Advanced Functional Materials, Год журнала: 2021, Номер 31(31)

Опубликована: Май 13, 2021

Abstract In human systems, reactive oxygen species (ROS) significantly affect different physiological activities and play critical roles in diverse living processes. It is widely known that excessive ROS generation inflammatory tissues can further deteriorate the localized tissue injury cause chronic diseases. Though promising for reducing levels, many antioxidant molecules natural enzymes suffer from abundant intrinsic limitations. Recently, a series of biocatalytic or nanostructures have been designed with distinctive scavenging capabilities, which show to overcome these kernel challenges. this timely review, most recent advances engineering are summarized. First, principles corresponding methods testing various enzymatic carefully concluded. Subsequently, rationally high efficiencies comprehensively discussed, especially on catalytic activities, mechanisms, structure‐function relationships. After that, representative applications biotherapeutics summarized detail. At last, primary challenges future perspectives emerging research frontier also outlined. believed progress review will offer cutting‐edge understanding guidance high‐performance broad biotherapeutic applications.

Язык: Английский

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Synergistic Reinforcing of Immunogenic Cell Death and Transforming Tumor‐Associated Macrophages Via a Multifunctional Cascade Bioreactor for Optimizing Cancer Immunotherapy

Advanced Materials, Год журнала: 2022, Номер 34(51)

Опубликована: Окт. 17, 2022

Immunogenic cell death (ICD) has aroused widespread attention because it can reconstruct a tumor microenvironment and activate antitumor immunity. This study proposes two-way enhancement of ICD based on CaO2 @CuS-MnO2 @HA (CCMH) nanocomposite to overcome the insufficient damage-associated molecular patterns (DAMPs) conventional ICD-inducers. The near-infrared (NIR) irradiation (1064 nm) CuS nanoparticles generates 1 O2 through photodynamic therapy (PDT) trigger ICD, also damages Ca2+ buffer function mitochondria. Additionally, react with H2 O produce large amount , which respectively lead enhanced PDT overload during mitochondrial damage, thereby triggering robust activation. Moreover, oxidative-damaged DNA, induced by released from cells, reprograms immunosuppressive transforming tumor-associated macrophages M1 subphenotype. shows that CCMH NIR-II elicit adequate DAMPs an active tumor-immune for both 4T1 CT26 models. Combining this method immune checkpoint blockade realize improved immunotherapy efficacy long-term protection effect body.

Язык: Английский

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Theranostic Fluorescent Probes

Chemical Reviews, Год журнала: 2024, Номер 124(5), С. 2699 - 2804

Опубликована: Фев. 29, 2024

The ability to gain spatiotemporal information, and in some cases achieve control, the context of drug delivery makes theranostic fluorescent probes an attractive intensely investigated research topic. This interest is reflected steep rise publications on topic that have appeared over past decade. Theranostic probes, their various incarnations, generally comprise a fluorophore linked masked drug, which released as result certain stimuli, with both intrinsic extrinsic stimuli being reported. release then signaled by emergence signal. Importantly, use appropriate fluorophores has enabled not only this emerging fluorescence marker for but also provided modalities useful photodynamic, photothermal, sonodynamic therapeutic applications. In review we highlight recent work particular focus are activated tumor microenvironments. We summarize efforts develop other applications, such neurodegenerative diseases antibacterials. celebrates diversity designs reported date, from discrete small-molecule systems nanomaterials. Our aim provide insights into potential clinical impact still-emerging direction.

Язык: Английский

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Recent advances on modulation of H2O2 in tumor microenvironment for enhanced cancer therapeutic efficacy

Coordination Chemistry Reviews, Год журнала: 2023, Номер 481, С. 215049 - 215049

Опубликована: Фев. 9, 2023

Язык: Английский

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Biomineralized Two‐Enzyme Nanoparticles Regulate Tumor Glycometabolism Inducing Tumor Cell Pyroptosis and Robust Antitumor Immunotherapy

Advanced Materials, Год журнала: 2022, Номер 34(50)

Опубликована: Окт. 4, 2022

Currently, immune checkpoint therapy combined with chemotherapy and radiotherapy is a useful strategy for improving immunotherapy's therapeutic efficacy. However, cause serious side effects, so finding safe effective methods to combine immunotherapy critical. In this work, regulating tumor glycometabolism found induce cell pyroptosis regulate the degree of expression programmed death-ligand 1 (PD-L1). Therefore, how treat tumors by in combination anti-PD-L1 investigated here. First, biomineralization-like method used construct nanoparticles two-enzymatic activity hybridizing nanozymes glucose oxidase (GOx). It has ability self-amplify regulation cells. can also increase PD-L1 To tumors, are further anti-PD-L1, which substantially inhibits development significantly increases survival time mice. Combination significant immunological memory effect, successfully preventing recurrence metastasis. This thought be first study that combines immunocheckpoint blocking cancer therapy. innovative, safe, low-toxic, highly anti-tumor have good prospects clinical applications.

Язык: Английский

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