Palladium catalysts supported on biodegradable urea-based polymers in synthesis with CO – part B

Catalysis Today, Год журнала: 2024, Номер 440, С. 114831 - 114831

Опубликована: Май 24, 2024

Язык: Английский

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Nucleophilic addition of bulk chemicals with imines using N-functionalized hydroxylamine reagents as precursors

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 2, 2025

C–C and C–X bond forming reactions are essential tools in organic synthesis, constantly revolutionizing human life. Among the key methods for constructing new chemical bonds nucleophilic addition involving imines. However, inherent challenges synthesizing storing imines have stimulated interest designing stable precursors, which generates situ during reaction. This approach offers a promising alternative to traditional strategies holds significant potential future applications. Here we report direct general of with cost-effective feedstocks easily accessible nucleophiles, specifically utilizing N‑functionalized hydroxylamine reagents as bench-stable precursors. methodology streamlines synthesis various products, such amino acid derivatives, through wide range reaction types, including C–C, C–N, C–O, C–S constructions. Mechanistic studies DFT calculations provide insights into plausible mechanism that supports in-situ imine formation. The stimulate precursors can generate Here, authors N functionalized

Язык: Английский

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Flow heterogeneous catalysis via stable dispersion of silica gel-supported catalysts

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161346 - 161346

Опубликована: Март 1, 2025

Язык: Английский

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Defying the oxidative-addition prerequisite in cross-coupling through artful single-atom catalysts

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 25, 2025

Heterogeneous single-atom catalysts (SACs) have gained significant attention for their maximized atom utilization and well-defined active sites, but they often struggle with multi-stage organic cross-coupling reactions due to limited coordination space reactivity. Here, we report an “anchoring-borrowing” strategy combined facet engineering develop artful (ASACs) through anchoring foreign single atoms onto specific facets of the non-innocent reducible carriers. ASACs exhibit adaptive coordination, effectively bypassing oxidative-addition prerequisite bivalent elevation at a metal site in both homogenous heterogeneous cross-couplings. For example, Pd₁-CeO₂(110) ASAC exhibits unparalleled activity coupling more accessible aryl chlorides, challenging heterocycles, outperforming traditional remarkable turnover number 45,327,037. Mechanistic studies reveal that leverage dynamic structural changes, carriers acting as electron reservoirs, significantly lowering reaction barriers. Furthermore, enable efficient synthesis biologically compounds, drug intermediates, pharmaceutical ingredients (APIs) scalable high-speed circulated flow synthesis, underscoring great potential sustainable fine chemical manufacturing.

Язык: Английский

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Self-pillared hierarchical Silicalite-1 zeolites for enhanced Suzuki-Miyaura coupling reactions

Carbon Resources Conversion, Год журнала: 2025, Номер unknown, С. 100331 - 100331

Опубликована: Апрель 1, 2025

Язык: Английский

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