Angewandte Chemie,
Год журнала:
2023,
Номер
136(11)
Опубликована: Дек. 14, 2023
Abstract
The
use
of
reactive
gaseous
reagents
for
the
production
active
pharmaceutical
ingredients
(APIs)
remains
a
scientific
challenge
due
to
safety
and
efficiency
limitations.
implementation
continuous‐flow
reactors
has
resulted
in
rapid
development
gas‐handling
technology
because
several
advantages
such
as
increased
interfacial
area,
improved
mass‐
heat
transfer,
seamless
scale‐up.
This
enables
shorter
more
atom‐economic
synthesis
routes
compounds.
Herein,
we
provide
an
overview
literature
from
2016
onwards
well
gases
functionalization
APIs.
Journal of the American Chemical Society,
Год журнала:
2023,
Номер
145(8), С. 4355 - 4365
Опубликована: Фев. 14, 2023
How
do
you
get
into
flow?
We
trained
in
flow
chemistry
during
postdoctoral
research
and
are
now
applying
it
new
areas:
materials
chemistry,
crystallization,
supramolecular
synthesis.
Typically,
when
researchers
think
of
"flow",
they
considering
predominantly
liquid-based
organic
synthesis;
application
to
other
disciplines
comes
with
its
own
challenges.
In
this
Perspective,
we
highlight
why
use
champion
technologies
our
fields,
summarize
some
the
questions
encounter
discussing
entry
research,
suggest
steps
make
transition
field,
emphasizing
that
communication
collaboration
between
is
key.
Abstract
Flow
processing
offers
many
opportunities
to
optimize
reactions
in
a
rapid
and
automated
manner,
yet
often
requires
relatively
large
quantities
of
input
materials.
To
combat
this,
the
use
flexible
slug
flow
reactor,
equipped
with
two
analytical
instruments,
for
low‐volume
optimization
experiments
are
reported.
A
Buchwald–Hartwig
amination
toward
drug
olanzapine,
6
independent
optimizable
variables,
is
optimized
using
three
different
approaches:
self‐optimization,
design
experiments,
kinetic
modeling.
These
approaches
complementary
provide
differing
information
on
reaction:
pareto
optimal
operating
points,
response
surface
models,
mechanistic
respectively.
The
results
achieved
<10%
material
that
would
be
required
standard
operation.
Finally,
chemometric
model
built
utilizing
data
handling
subsequent
validation
demonstrate
good
agreement
between
reactor
(larger
scale)
reactor.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
63(11)
Опубликована: Дек. 14, 2023
The
use
of
reactive
gaseous
reagents
for
the
production
active
pharmaceutical
ingredients
(APIs)
remains
a
scientific
challenge
due
to
safety
and
efficiency
limitations.
implementation
continuous-flow
reactors
has
resulted
in
rapid
development
gas-handling
technology
because
several
advantages
such
as
increased
interfacial
area,
improved
mass-
heat
transfer,
seamless
scale-up.
This
enables
shorter
more
atom-economic
synthesis
routes
compounds.
Herein,
we
provide
an
overview
literature
from
2016
onwards
well
gases
functionalization
APIs.
Reaction Chemistry & Engineering,
Год журнала:
2023,
Номер
8(5), С. 955 - 977
Опубликована: Янв. 1, 2023
This
review
provides
a
holistic
description
of
flow
reactor
fouling
for
wet-chemical
nanomaterial
syntheses.
Fouling
origins
and
consequences
are
discussed
together
with
the
variety
reactors
its
prevention.
Lab on a Chip,
Год журнала:
2022,
Номер
23(5), С. 1349 - 1357
Опубликована: Окт. 12, 2022
For
decades,
a
production
paradigm
based
on
centralized,
stepwise,
large
scale
processes
has
dominated
the
chemical
industry
horizon.
While
effective
to
meet
an
ever
increasing
demand
for
high
value-added
chemicals,
so-called
macroscopic
batch
reactors
are
also
associated
with
inherent
weaknesses
and
threats;
some
of
most
obvious
ones
were
tragically
illustrated
over
past
decades
major
industrial
disasters
impactful
disruptions
advanced
supplies.
The
COVID
pandemic
further
emphasized
that
change
in
was
necessary
sustain
increased
safety,
reliable
supply
chains
adaptable
productivities.
More
than
decade
research
technology
development
led
alternative
relying
miniaturised
flow
(a.k.a.
micro
mesofluidic
reactors).
Such
bear
potential
solve
safety
concerns
improve
reliability
chains.
Will
they
initiate
new
more
localized,
safe
production?
Reaction Chemistry & Engineering,
Год журнала:
2023,
Номер
8(11), С. 2818 - 2825
Опубликована: Янв. 1, 2023
Using
dynamic
flow
experiments,
a
predictive
reaction
model
can
be
rapidly
fitted.
Here,
up
to
five
different
input
parameters
were
varied
simultaneously,
allowing
rapid
exploration
of
design
space.
