Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Дек. 20, 2024
We present an efficient flow method for the preparation of disubstituted alkynes from isoxazolones under diazotisation conditions. This overcomes reproducibility issues batch variant and safely affords alkyne products on gram scale.
Язык: Английский
ChemSusChem, Год журнала: 2024, Номер 17(16)
Опубликована: Апрель 12, 2024
Abstract Photocatalytic synthesis of value‐added chemicals has gained increasing attention in recent years owing to its versatility driving many important reactions under ambient conditions. Selective hydrogenation, oxidation, coupling, and halogenation with a high conversion the reactants have been realized using designed photocatalysts batch reactors small volumes at laboratory scale; however, scaling‐up remains critical challenge due inefficient utilization incident light active sites photocatalysts, resulting poor catalytic performance that hinders practical applications. Flow systems are considered one solutions for applications light‐driven experienced great success photolytic homogeneous photocatalysis, yet their heterogeneous photocatalysis still development. In this perspective, we summarized progress photocatalytic synthetic chemistry performed flow from view reactor design special focus on photocatalysis. The advantages limitations different systems, as well some considerations strategies discussed.
Язык: Английский
Процитировано
7
Reviews in Inorganic Chemistry, Год журнала: 2024, Номер 44(3), С. 323 - 337
Опубликована: Фев. 16, 2024
Abstract In the last few decades, photochemistry has great influence on all type of synthetic processes. While photochemical synthesis is emerging field in inorganic chemistry as it impart various magnificent properties to materials that are used for nano-sized giant supramolecular structures. There many based approaches like electron, atom, energy transfer depending upon need product where one can switch pathway. A variety compounds have been synthesized dienes, nitrides, indoles, gold nano-particles and structures using route. Photochemical applications artificial photosynthesis fluorophores.
Язык: Английский
Процитировано
4
Advanced Synthesis & Catalysis, Год журнала: 2023, Номер 366(4), С. 710 - 716
Опубликована: Сен. 14, 2023
Abstract Flow chemistry has recently opened new windows thanks to the safer use of hazardous and sensitive reagents. Furthermore, flow procedures usually outperform their batch counterparts due improved mass heat transfer, offering a good opportunity for industrial application. Herein, rapid Simmons‐Smith cyclopropanation process is presented. Taking advantage in situ production zinc carbenoid species, several olefins bearing aromatic rings different electronic nature, aliphatic chains or heterocycles were smoothly cyclopropanated with residence time just 15 minutes. In addition, applicability protocol assured successful 12‐mmol scale experiment, which represents 3.59 grams per hour selected example, satisfactory synthesis pharmaceutical drugs.
Язык: Английский
Процитировано
9
Current Opinion in Green and Sustainable Chemistry, Год журнала: 2024, Номер 47, С. 100907 - 100907
Опубликована: Март 13, 2024
Reactive intermediates are transient high-energy species playing a pivotal role in the synthesis of organic molecules. Continuous flow processing is frequently exploited generating plethora reactive situ followed by their rapid transformation to target Reactor miniaturisation along with high heat and mass transfer rates key features that these processes provide for additional benefits such as safety scalability. This short review highlights recent advances field chemistry generation use photochemical reactions, low-temperature sequences well related transformations.
Язык: Английский
Процитировано
3
Organic Process Research & Development, Год журнала: 2023, Номер 27(12), С. 2385 - 2392
Опубликована: Ноя. 24, 2023
We report the development of a deoxyfluorination protocol using sulfur tetrafluoride (SF4) as reagent to prepare organofluorine compounds in continuous flow mode. The method uses mild conditions, without use HF, which provides an improved safety profile. methodology was applied successfully convert various alcohols, aldehydes, and carboxylic acids their corresponding fluorinated compounds. Advantages include tolerance protecting groups, high enantioselective control, easy incorporation inline reaction monitoring.
Язык: Английский
Процитировано
8
Chemistry - An Asian Journal, Год журнала: 2023, Номер 18(21)
Опубликована: Сен. 14, 2023
Fluorination reactions are important in constructing organofluorine motifs, which contribute to favorable biological properties pharmaceuticals and agrochemicals. However, fluorination reagents associated with various problems, such as their hazardous nature, high exothermicity, poor selectivity scalability. Continuous flow has emerged a transformative technology provide many advantages relative batch syntheses. This review article summarizes recent continuous techniques that address the limitations challenges of reactions. Approaches based on different discussed, including gas-liquid reactions, packed-bed reactors, in-line purifications, streamlined multistep synthesis, large-scale well photoredox- electrocatalysis.
Язык: Английский
Процитировано
7
Organic Process Research & Development, Год журнала: 2024, Номер 28(8), С. 3284 - 3294
Опубликована: Июль 24, 2024
Herein, we report an optimized process for 2,4-dichloro-5-fluoroacetophenone, a key intermediate of ciprofloxacin. In the nitration step, traditional mixed acid was replaced by microchannel continuous reaction technology. For fluorination reactions, quaternary ammonium salt catalyst novel CNC+ catalyst, which led to improved catalytic efficiency, lowered temperatures, and increased product yields. Furthermore, cost-effective method utilizing waste gases with high concentrations nitrogen oxides developed nitrochlorination reaction. acetylation magnetic materials featuring both Bronsted Lewis sites were utilized immobilize bisacid site [HPhIm][FeCl4]/MPNs, replacing AlCl3 approach. The overall yield this new sustainable across all four steps reached 86.4%, marking significant improvement over 10% compared method. Moreover, has resulted in 87% reduction emissions remarkable 96% exhaust emissions.
Язык: Английский
Процитировано
1
Journal of Fluorine Chemistry, Год журнала: 2024, Номер 279, С. 110349 - 110349
Опубликована: Сен. 14, 2024
Язык: Английский
Процитировано
1
Organic Process Research & Development, Год журнала: 2024, Номер 28(8), С. 3273 - 3283
Опубликована: Июль 31, 2024
Azvudine was approved for the treatment of adult HIV-1 infection in China 2021, and it conditional marketing SARS-CoV-2 2022. In this work, we describe a fully continuous flow synthesis 2′-deoxy-2′-fluoroarabinoside, key intermediate azvudine. The process accomplished via six chemical transformations, including chlorination, hydrolysis, fluorination, bromination, condensation, deprotection sequential devices. Under optimized conditions, total yield 32.3% with residence time 156 min. Compared batch doubled, reaction shortened 16 times, E factor reduced 1.63 times.
Язык: Английский
Процитировано
0
Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Дек. 20, 2024
We present an efficient flow method for the preparation of disubstituted alkynes from isoxazolones under diazotisation conditions. This overcomes reproducibility issues batch variant and safely affords alkyne products on gram scale.
Язык: Английский
Процитировано
0