The Use of Phosphotriesterase in the Synthesis of Enantiomerically Pure ProTide Prodrugs.

Chemico-Biological Interactions, Год журнала: 2025, Номер unknown, С. 111597 - 111597

Опубликована: Июнь 1, 2025

Язык: Английский

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Towards Clinical Development of Scandium Radioisotope Complexes for Use in Nuclear Medicine: Encouraging Prospects with the Chelator 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid (DOTA) and Its Analogues

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 5954 - 5954

Опубликована: Май 29, 2024

Scandium (Sc) isotopes have recently attracted significant attention in the search for new radionuclides with potential uses personalized medicine, especially treatment of specific cancer patient categories. In particular, Sc-43 and Sc-44, as positron emitters a satisfactory half-life (3.9 4.0 h, respectively), are ideal diagnosis via Positron Emission Tomography (PET). On other hand, Sc-47, an emitter beta particles low gamma radiation, may be used therapeutic radionuclide, which also allows Single-Photon Computed (SPECT) imaging. As these scandium follow same biological pathway chemical reactivity, they appear to fit perfectly into "theranostic pair" concept. A step-by-step description, initiating from moment isotope production leading up their preclinical clinical trial applications, is presented. Recent developments related nuclear reactions selected employed produce Sc-43, processing main target recovery methods included. Furthermore, radiolabeling chelator, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), its structural analogues discussed advantages disadvantages complexation evaluated. Finally, review studies trials involving scandium, well future challenges

Язык: Английский

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Tenofovir Prodrug Synthesis Inspires Novel C–P Bond-Forming Method

Synfacts, Год журнала: 2023, Номер 19(08), С. 0827 - 0827

Опубликована: Июль 14, 2023

Key words tenofovir prodrug - Pummerer reaction carbon-phosphorus bond formation

Язык: Английский

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