Optimizing Phosphine Ligands for Ruthenium Catalysts in Asymmetric Hydrogenation of β-Keto Esters: The Role of Water in Activity and Selectivity

Molecular Catalysis, Год журнала: 2025, Номер 574, С. 114877 - 114877

Опубликована: Фев. 4, 2025

Язык: Английский

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Copper-Catalyzed Dynamic Kinetic Asymmetric Arylation of Secondary Phosphine-Boranes for the Synthesis of P(III)-Stereogenic Centers

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 14, 2025

Transition-metal-catalyzed asymmetric C-P(III) bond formation is a direct method for the construction of P(III)-stereogenic centers; however, achieving high enantioselectivity remains challenge. Herein, an unprecedented Cu-catalyzed dynamic kinetic resolution secondary phosphine-boranes was successfully developed. This C-P(BH3) coupling reaction provided and highly enantioselective synthesis centers, enabling chiral medium-sized benzophosphine-boranes (7-10-membered cycles). A mechanism involving unusual rapid racemization has been proposed.

Язык: Английский

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Synthesis of benzoheterocycles by palladium-catalyzed migratory cyclization through an unexpected reaction cascade

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 9, 2025

Migratory functionalization of C-H bonds through metal migration from carbon to under transition catalysis is a process significant academic and industrial interest. Herein, palladium-catalyzed migratory cyclization α-bromoalkene derivatives ArXCBr=CH2, in which X denotes phosphorus (P(O)R), silicon (SiR2), sulfur (SO2), (C(O)), nitrogen (NTs), or oxygen-based moiety, affording various benzoheterocyclic compounds has been developed. Mechanistic investigations have demonstrated that the reaction proceeds an unexpected cascade, with trans-1,2-palladium between sp2 carbons being key step catalytic cycle. To best our knowledge, this type not reported previously.

Язык: Английский

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Ruthenium Complexes for Asymmetric Hydrogenation and Selective Dehalogenation Revealed via Bayesian Optimization

Industrial & Engineering Chemistry Research, Год журнала: 2025, Номер unknown

Опубликована: Май 27, 2025

Язык: Английский

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Gold/HNTf₂-Cocatalyzed Asymmetric Annulation of Diazo-Alkynes: Divergent Construction of Atropisomeric Biaryls and Arylquinones

Journal of the American Chemical Society, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 30, 2024

Due to the inherent challenges posed by linear coordination of gold(I) complexes, asymmetric gold-catalyzed processes remain challenging, particularly in atroposelective synthesis axially chiral skeletons. Except for extremely few examples intramolecular annulations, construction axial chirality via intermolecular alkyne transformation is still undeveloped. Herein, a gold/HNTf

Язык: Английский

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Synthesis of a Sitagliptin Intermediate via Ruthenium-Catalyzed Asymmetric Hydrogenation of Enamine Ester

Chinese Journal of Organic Chemistry, Год журнала: 2024, Номер 44(12), С. 3720 - 3720

Опубликована: Янв. 1, 2024

Язык: Английский

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