Activation of Carbon─Chlorine Bond at Chlorpromazine for Access to New Derivatives Through Nickel‐Catalyzed Kumada–Tamao–Corriu Cross‐Coupling Reaction DOI

Rafid S. Dawood

ChemistrySelect, Год журнала: 2025, Номер 10(17)

Опубликована: Апрель 28, 2025

Abstract This study presents a simple and effective reaction for creating new derivatives of chlorpromazine with various substituents at C‐2, which is achieved through the Kumada–Tamao–Corriu cross‐coupling reaction. A moderate to excellent yield (39%–82%) was obtained under nickel(II) catalysis in presence readily available achiral organophosphorus ligand.

Язык: Английский

Advancing Base Metal Catalysis: Development and Execution of a Ni-catalyzed Borylation/Pd-catalyzed Suzuki Telescoped Process DOI
Matthew V. Joannou, Matthew J. Goldfogel, Eric M. Simmons

и другие.

Organic Process Research & Development, Год журнала: 2025, Номер unknown

Опубликована: Фев. 10, 2025

Язык: Английский

Процитировано

0
Activation of Carbon─Chlorine Bond at Chlorpromazine for Access to New Derivatives Through Nickel‐Catalyzed Kumada–Tamao–Corriu Cross‐Coupling Reaction DOI

Rafid S. Dawood

ChemistrySelect, Год журнала: 2025, Номер 10(17)

Опубликована: Апрель 28, 2025

Abstract This study presents a simple and effective reaction for creating new derivatives of chlorpromazine with various substituents at C‐2, which is achieved through the Kumada–Tamao–Corriu cross‐coupling reaction. A moderate to excellent yield (39%–82%) was obtained under nickel(II) catalysis in presence readily available achiral organophosphorus ligand.

Язык: Английский

Процитировано

0