Handbook of CH‐Functionalization,
Год журнала:
2022,
Номер
unknown, С. 1 - 48
Опубликована: Окт. 1, 2022
Abstract
Transition
metal‐catalyzed
transformations
involving
converting
CH
bonds
into
CC
or
CX
bond
have
been
extensively
explored,
which
expedite
the
synthesis
of
target
molecules
via
novel
and
efficient
disconnections
in
retrosynthetic
analysis.
Directing
group‐assisted
activation
is
one
most
used
strategy
to
obtain
site‐selective
functionalization.
Ideal
directing
groups
are
ubiquitously
available,
stable,
easily
removed,
transformable.
Carboxylates
perfectly
meet
with
those
prerequisites.
Carboxylic
acids
widely
exist
organic
molecules,
can
be
tracelessly
removed
by
protodecarboxylation
converted
other
functional
groups.
Thus,
carboxylate‐directed
significant
importance.
Scientia Sinica Chimica,
Год журнала:
2023,
Номер
53(9), С. 1735 - 1740
Опубликована: Июнь 27, 2023
The
direct
functionalization
of
C–H
bonds
has
become
an
efficient
method
for
constructing
carbon–carbon
in
organic
synthesis.
As
the
transformation
does
not
require
pre-functionalization,
it
is
regarded
as
atom-economic
and
step-economic
method.
The
transition
metal
catalyzed
selective
provides
a
concise
construction
C–C
C–X
bonds.
Although
Rh(III)-catalyzed
ring-opening
reactions
azabenzonorbornadienes
via
activation
have
been
studied,
usually
addition
oxidant
or
harsh
reaction
conditions.
Herein,
we
develop
with
2-arylindole,
which
oxidants,
featured
by
high
regioselectivity
stereoselectivity
good
functional
group
compatibility.
yield
up
to
98%
under
mild
condition,
thus
convenient
synthesis
2-aryl
hydrogenaphthalene
derivatives.
Angewandte Chemie,
Год журнала:
2023,
Номер
136(1)
Опубликована: Ноя. 9, 2023
Abstract
A
Pd
II
‐catalyzed,
domino
enantioselective
desymmetrizative
coupling
of
7‐azabenzonorbornadienes
with
alkynylanilines
is
disclosed
herein.
This
operationally
simple
transformation
generates
three
covalent
bonds
and
two
contiguous
stereocenters
excellent
enantio‐
diastereo‐selectivity.
The
resulting
functionalized
indole‐dihydronaphthalene‐amine
conjugates
served
as
an
appealing
platform
to
streamline
the
diversity‐oriented
synthesis
(DOS)
other
valuable
enantioenriched
compounds.
DFT
calculations
revealed
that
stabilizing
non‐covalent
interactions
contributed
observed
enantioselectivity.
Handbook of CH‐Functionalization,
Год журнала:
2022,
Номер
unknown, С. 1 - 48
Опубликована: Окт. 1, 2022
Abstract
Transition
metal‐catalyzed
transformations
involving
converting
CH
bonds
into
CC
or
CX
bond
have
been
extensively
explored,
which
expedite
the
synthesis
of
target
molecules
via
novel
and
efficient
disconnections
in
retrosynthetic
analysis.
Directing
group‐assisted
activation
is
one
most
used
strategy
to
obtain
site‐selective
functionalization.
Ideal
directing
groups
are
ubiquitously
available,
stable,
easily
removed,
transformable.
Carboxylates
perfectly
meet
with
those
prerequisites.
Carboxylic
acids
widely
exist
organic
molecules,
can
be
tracelessly
removed
by
protodecarboxylation
converted
other
functional
groups.
Thus,
carboxylate‐directed
significant
importance.
