Chemistry - A European Journal,
Год журнала:
2023,
Номер
30(7)
Опубликована: Ноя. 6, 2023
Reaching
the
formidable
C-H
corners
has
been
one
of
top
priorities
organic
chemists
in
recent
past.
This
prompted
us
to
disclose
herein
a
vicinal
annulation
2-iodo
benzoates,
indoles,
and
carbazoles
with
N-embedded
1,6-enynes
through
7-/8-membered
palladacycles.
The
relay
does
not
require
assistance
any
directing
group,
leading
multicyclic
scaffolds,
which
are
readily
diversified
an
array
adducts
(with
new
functional
tethers
and/or
three
contiguous
stereocenters),
we
showcase
rare
benzylic
mono-oxygenation.
Asian Journal of Organic Chemistry,
Год журнала:
2021,
Номер
10(10), С. 2580 - 2590
Опубликована: Авг. 20, 2021
A
one-pot
spirocyclization
of
2-aryl-2,3-dihydrophthalazine-1,4-diones
with
maleimides
was
achieved
via
RhIII-catalyzed
sequential
ortho-alkenylation
followed
by
intramolecular
aza-Michael-type
addition/protonation
process.
The
featured
strategy
furnishes
a
series
diversely
decorated
spiro[indazolo[1,2-b]phthalazine-13,3′-pyrrolidine]-2′,5′,6,11-tetraones
in
high
yields
from
variety
and
N-aryl/alkyl
maleimides,
which
can
be
scaled-up
easily.
Isolation
characterization
maleimide-coordinated
five-membered
rhodacyclic
intermediate
provided
strong
evidence
for
the
proposed
mechanism
reaction.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
unknown
Опубликована: Март 20, 2024
Abstract
We
report
herein
a
palladium‐catalyzed,
site‐selective
cyclative
annulation
of
o
‐alkynyl
arylamides
with
maleimide
for
the
stereoselective
construction
succinimide‐fused
benzoxazine
derivatives.
This
operationally
simple
and
modular
protocol
provides
access
to
polycyclic
frameworks.
The
other
associated
features
are
high
functional
group
compatibility,
gram‐scale
synthetic
potential,
downstream
transformations.
Control
labeling
experiments
were
conducted
get
insights
into
mechanism.
Transition-metal-catalyzed
C-H
activation
has
proven
to
be
a
powerful
tool
for
the
late-stage
modification
of
peptides.
We
herein
report
method
site-selective
alkylation
peptides
with
maleimides
through
Pd-catalyzed
β-C(sp
Organic & Biomolecular Chemistry,
Год журнала:
2022,
Номер
20(32), С. 6368 - 6383
Опубликована: Янв. 1, 2022
A
rare
dipolarophile-induced
diastereo-selective
amidative
annulation
and
concomitant
3
+
2
cycloaddition
are
reported
using
α-amino
acids,
amino
aldehydes
maleimides.
Chemistry - A European Journal,
Год журнала:
2023,
Номер
30(7)
Опубликована: Ноя. 6, 2023
Reaching
the
formidable
C-H
corners
has
been
one
of
top
priorities
organic
chemists
in
recent
past.
This
prompted
us
to
disclose
herein
a
vicinal
annulation
2-iodo
benzoates,
indoles,
and
carbazoles
with
N-embedded
1,6-enynes
through
7-/8-membered
palladacycles.
The
relay
does
not
require
assistance
any
directing
group,
leading
multicyclic
scaffolds,
which
are
readily
diversified
an
array
adducts
(with
new
functional
tethers
and/or
three
contiguous
stereocenters),
we
showcase
rare
benzylic
mono-oxygenation.
