Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(24)
Опубликована: Март 25, 2022
A
palladium-catalyzed
chemoselective
coupling
of
readily
available
bicyclo[1.1.1]pentanyl
alcohols
(BCP-OH)
with
various
halides
is
reported,
which
offers
expedient
approaches
to
a
wide
range
cyclobutanone
and
β,γ-enone
skeletons
via
single
or
double
C-C
activation.
The
chemistry
shows
broad
substrate
scope
in
terms
both
the
BCP-OH
including
series
natural
product
derivatives.
Moreover,
dependency
reaction
chemodivergence
on
base
additive
has
been
investigated
through
experimental
density
functional
theory
(DFT)
studies,
expected
significantly
enrich
modes
increase
synthetic
potential
preparing
more
complex
molecules.
Green Chemistry,
Год журнала:
2024,
Номер
26(3), С. 1375 - 1380
Опубликована: Янв. 1, 2024
A
visible-light-mediated
tandem
ring
opening/1,6-conjugate
addition
of
cyclobutanols
with
p
-quinone
methides
was
developed.
This
protocol
allowed
the
formation
δ,δ-diaryl
ketones
in
presence
a
readily
available
organic
photocatalyst.
Organic Letters,
Год журнала:
2024,
Номер
26(10), С. 2114 - 2118
Опубликована: Март 4, 2024
Herein,
we
report
a
general
and
practical
nickel-catalyzed
deaminative
alkylation
of
Katritzky
salts
with
cyclopropyl
alcohols
via
merging
C–N
C–C
bond
activation.
This
protocol
enables
the
formation
an
alkyl–alkyl
along
generation
versatile
ketone
functional
group
in
single
operation,
thus
providing
convenient
approach
for
accessing
β-alkyl
ketones.
reaction
is
distinguished
by
its
high
tolerance,
broad
substrate
scope,
efficient
late-stage
derivatization
complex
bioactive
molecules.
Organic Letters,
Год журнала:
2021,
Номер
23(15), С. 5993 - 5997
Опубликована: Июль 22, 2021
We
report
herein
a
nickel-catalyzed
ring-opening
allylation
of
cyclopropanols
with
allylic
carbonates
that
occurs
under
mild
and
neutral
conditions.
The
reaction
displays
linear
selectivity
for
both
branched
acyclic
is
also
applicable
to
cyclic
carbonates,
affording
variety
δ,ε-unsaturated
ketones
in
moderate
good
yields.
Mechanistic
experiments
are
accord
catalytic
cycle
involving
decarboxylative
oxidative
addition
carbonate
Ni(0),
alkoxide
exchange
cyclopropanol,
cyclopropoxide-to-homoenolate
conversion
on
Ni(II),
C–C
reductive
elimination.
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(24)
Опубликована: Март 25, 2022
A
palladium-catalyzed
chemoselective
coupling
of
readily
available
bicyclo[1.1.1]pentanyl
alcohols
(BCP-OH)
with
various
halides
is
reported,
which
offers
expedient
approaches
to
a
wide
range
cyclobutanone
and
β,γ-enone
skeletons
via
single
or
double
C-C
activation.
The
chemistry
shows
broad
substrate
scope
in
terms
both
the
BCP-OH
including
series
natural
product
derivatives.
Moreover,
dependency
reaction
chemodivergence
on
base
additive
has
been
investigated
through
experimental
density
functional
theory
(DFT)
studies,
expected
significantly
enrich
modes
increase
synthetic
potential
preparing
more
complex
molecules.
