Organic & Biomolecular Chemistry,
Год журнала:
2022,
Номер
20(44), С. 8633 - 8637
Опубликована: Янв. 1, 2022
A
base-promoted
[4
+
2]
annulation
of
pyrrole-2-carbaldehyde
derivatives
with
β,γ-unsaturated
α-ketoesters
for
the
syntheses
multisubstituted
5,6-dihydroindolizines
was
developed.
Molecules,
Год журнала:
2024,
Номер
29(9), С. 2061 - 2061
Опубликована: Апрель 29, 2024
Herein,
we
have
developed
a
new
approach
for
the
synthesis
of
indolizine
via
Cu-catalyzed
reaction
pyridine,
acetophenone,
and
nitroolefin
under
mild
conditions
in
high
yields.
This
involved
formation
C–N
C–C
bonds
compounds
with
stereoselectivity
excellent
functional
group
tolerance.
Chemistry - A European Journal,
Год журнала:
2024,
Номер
30(63)
Опубликована: Авг. 23, 2024
Abstract
A
base
promoted
oxidative
[4+2]
annulation
of
pyrrole‐2‐carbaldehyde
derivatives
with
o
‐hydroxyphenyl
propargylamines
for
the
synthesis
highly
substituted
indolizines
has
been
developed.
Using
DBN
as
base,
a
broad
range
5,6,7‐trisubstituted
have
prepared
in
good
to
excellent
yields
under
mild
conditions,
and
many
useful
functional
groups
can
be
tolerated.
The Journal of Organic Chemistry,
Год журнала:
2021,
Номер
87(1), С. 835 - 845
Опубликована: Дек. 28, 2021
An
efficient
method
for
the
synthesis
of
new
indolizine-fused
chromones
has
been
accomplished
from
ethyl
(E)-3-(2-acetylphenoxy)acrylates
and
pyridines
in
a
"one-pot"
manner.
Facile
operation
open-air,
metal-free,
mild
conditions
renders
this
protocol
particularly
practical
attractive.
Moreover,
can
simultaneously
construct
two
molecular
fragments
chromone
indolizine.
Scale-up
experiment
construction
natural
products
further
prove
practicability
strategy.
Organic & Biomolecular Chemistry,
Год журнала:
2022,
Номер
20(44), С. 8633 - 8637
Опубликована: Янв. 1, 2022
A
base-promoted
[4
+
2]
annulation
of
pyrrole-2-carbaldehyde
derivatives
with
β,γ-unsaturated
α-ketoesters
for
the
syntheses
multisubstituted
5,6-dihydroindolizines
was
developed.