Base-promoted [4 + 2] annulation of pyrrole-2-carbaldehyde derivatives with β,γ-unsaturated α-ketoesters: syntheses of 5,6-dihydroindolizines DOI

You‐Ya Zhang,

Lin Li, Ai‐Jun Ma

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2022, Номер 20(44), С. 8633 - 8637

Опубликована: Янв. 1, 2022

A base-promoted [4 + 2] annulation of pyrrole-2-carbaldehyde derivatives with β,γ-unsaturated α-ketoesters for the syntheses multisubstituted 5,6-dihydroindolizines was developed.

Язык: Английский

Efficient Solvent-Free Synthesis of Indolizines Using CuBr Catalyst from Pyridine, Acetophenone, and Electron-Deficient Alkenes DOI Creative Commons
Xueguo Zhang, Jianpeng Zhang, Zhengyi Liu

и другие.

Molecules, Год журнала: 2024, Номер 29(9), С. 2061 - 2061

Опубликована: Апрель 29, 2024

Herein, we have developed a new approach for the synthesis of indolizine via Cu-catalyzed reaction pyridine, acetophenone, and nitroolefin under mild conditions in high yields. This involved formation C–N C–C bonds compounds with stereoselectivity excellent functional group tolerance.

Язык: Английский

Процитировано

2
Oxidative [4+2] Annulation of Pyrrole‐2‐carbaldehyde Derivatives with o‐Hydroxyphenyl Propargylamines: Syntheses of 5,6,7‐Trisubstituted Indolizines DOI Open Access
Yuqing Wang,

L.‐Y. CHEN,

Ruilin Yang

и другие.

Chemistry - A European Journal, Год журнала: 2024, Номер 30(63)

Опубликована: Авг. 23, 2024

Abstract A base promoted oxidative [4+2] annulation of pyrrole‐2‐carbaldehyde derivatives with o ‐hydroxyphenyl propargylamines for the synthesis highly substituted indolizines has been developed. Using DBN as base, a broad range 5,6,7‐trisubstituted have prepared in good to excellent yields under mild conditions, and many useful functional groups can be tolerated.

Язык: Английский

Процитировано

2
Iodine-Mediated Domino Cyclization for One-Pot Synthesis of Indolizine-Fused Chromones via Metal-Free sp3 C–H Functionalization DOI

Xiangjin Zhang,

Zhuo Wang, Han Zhang

и другие.

The Journal of Organic Chemistry, Год журнала: 2021, Номер 87(1), С. 835 - 845

Опубликована: Дек. 28, 2021

An efficient method for the synthesis of new indolizine-fused chromones has been accomplished from ethyl (E)-3-(2-acetylphenoxy)acrylates and pyridines in a "one-pot" manner. Facile operation open-air, metal-free, mild conditions renders this protocol particularly practical attractive. Moreover, can simultaneously construct two molecular fragments chromone indolizine. Scale-up experiment construction natural products further prove practicability strategy.

Язык: Английский

Процитировано

13
N-Difluoromethylation of N-pyridyl-substituted anilines with ethyl bromodifluoroacetate DOI
Jindian Duan, Pui Ying Choy, Kin Boon Gan

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2022, Номер 20(9), С. 1883 - 1887

Опубликована: Янв. 1, 2022

A general protocol for N -difluoromethylation of aniline derivatives is developed.

Язык: Английский

Процитировано

9
Base-promoted [4 + 2] annulation of pyrrole-2-carbaldehyde derivatives with β,γ-unsaturated α-ketoesters: syntheses of 5,6-dihydroindolizines DOI

You‐Ya Zhang,

Lin Li, Ai‐Jun Ma

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2022, Номер 20(44), С. 8633 - 8637

Опубликована: Янв. 1, 2022

A base-promoted [4 + 2] annulation of pyrrole-2-carbaldehyde derivatives with β,γ-unsaturated α-ketoesters for the syntheses multisubstituted 5,6-dihydroindolizines was developed.

Язык: Английский

Процитировано

9