Chinese Journal of Organic Chemistry,
Год журнала:
2023,
Номер
43(8), С. 2864 - 2864
Опубликована: Янв. 1, 2023
A
Pd-catalyzed
decarboxylation
strategy
for
the
efficient
synthesis
of
cyclohepta
[b]indoles
in
good
yields
with
to
excellent
enantioselectivities
and
moderate
diastereoselectivities
is
reported.In
this
procedure,
viny
indoloxazolidones
were
activated
by
Pd
catalyst
generate
zwitterionic
intermediates
situ,
which
then
trapped
electro-deficient
diene
species
via
asymmetric
[3＋4]
cycloaddition
process.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(10), С. 4146 - 4174
Опубликована: Янв. 1, 2022
The
advances
on
metal-catalysed
high-order
dipolar
annulations
were
comprehensively
summarized
in
this
review.
To
further
exploit
the
potential
of
unique
annulation
strategy,
a
research
outlook
was
also
proposed.
Chemical Society Reviews,
Год журнала:
2023,
Номер
53(2), С. 883 - 971
Опубликована: Дек. 18, 2023
This
review
aims
to
collect
advancements
in
enantioselective
palladium-catalyzed
cyclization
reactions
over
the
past
eleven
years,
and
it
is
organized
into
thirteen
sections
depending
on
different
types
of
transformations
involved.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
63(6)
Опубликована: Дек. 15, 2023
Abstract
We
report
herein
an
unprecedented
enantioselective
(4+4)
cycloaddition
of
simple
1,3‐dienes
with
azadienes
for
the
construction
fused
eight‐membered
N
‐heterocycles.
In
this
transformation,
π‐Lewis
basic
Pd(0)
catalyst
achieves
activation
to
induce
nucleophilic
addition
followed
by
ring
cyclization
via
a
selective
terminal
allylic
substitution.
Furthermore,
highly
efficient
and
diastereoselective
derivatizations
rings
provide
facile
access
diverse
enantiopure
tetra‐
hexacyclic
compounds
potential
application
in
medicinal
chemistry.
Organic Chemistry Frontiers,
Год журнала:
2022,
Номер
9(17), С. 4685 - 4691
Опубликована: Янв. 1, 2022
We
developed
a
cycloisomerization/asymmetric
[4
+
3]
cycloaddition
cascade
reaction
via
gold/palladium
relay
catalysis,
furnishing
enantioenriched
furan-fused
azepines
efficiently.
Chinese Journal of Organic Chemistry,
Год журнала:
2022,
Номер
42(10), С. 3051 - 3051
Опубликована: Янв. 1, 2022
Chiral
heterocyclic
compounds
are
an
important
class
of
chiral
substances,
which
widespread
in
many
drugs,
pesticides
and
catalysts.Therefore,
the
efficient
asymmetric
synthesis
these
becomes
a
research
hotspot
organic
synthesis.Transition
metal-catalyzed
cyclization
with
heteroatom-dipole
precursors
is
method
to
construct
frameworks.Among
them,
designed
based
on
transition
allyl
or
propargyl
substitutions
have
been
extensively
studied
past
two
decades
occupied
role
this
field.The
cyclizations
introduced
detail.The
advantages
existing
problems
current
methods
analyzed,
would
provide
useful
reference
for
researchers
related
fields.
Advanced Synthesis & Catalysis,
Год журнала:
2022,
Номер
364(12), С. 2060 - 2066
Опубликована: Май 5, 2022
Abstract
A
palladium‐catalyzed
[4+2]
cycloaddition
of
hydroxy‐tethered
allyl
carbonates
with
five
types
electron‐deficient
alkenes
has
been
achieved,
in
which
a
type
new
acted
as
valuable
precursors
for
the
formation
1,4‐C,O‐dipole
allylpalladium
intermediates.
The
reaction
proceeded
efficiently
under
mild
conditions
to
provide
corresponding
tetrahydropyran
derivatives
moderate
high
yields
excellent
diastereoselectivities.
magnified
image
Chinese Journal of Chemistry,
Год журнала:
2023,
Номер
41(21), С. 2825 - 2831
Опубликована: Июнь 25, 2023
Comprehensive
Summary
We
developed
a
novel
Pd‐catalyzed
[4
+
4]
cycloaddition
of
(benzo)furan‐derived
azadienes
with
homo‐TMM
all‐carbon
1,4‐dipoles
in
situ
generated
from
α
‐allyl
malonate
derivatives,
affording
an
array
benzofuro[3,2‐
b
]azocines
and
furo[3,2‐
good
to
excellent
yields
(up
96%)
exclusive
regioselectivities.
This
methodology
featured
mild
reaction
conditions
functional
group
tolerance.
The
synthetic
utility
was
demonstrated
by
gram‐scale
reaction.
Furthermore,
the
catalytic
asymmetric
version
has
also
been
explored.
Organic Letters,
Год журнала:
2022,
Номер
24(20), С. 3747 - 3752
Опубликована: Май 13, 2022
A
phosphine-catalyzed
(4
+
2)
annulation
of
tetrahydrobenzofuranone-derived
allenoates
and
benzofuran-derived
azadienes
(BDAs)
has
been
achieved
to
construct
the
decahydro-2H-naphtho[1,8-bc]furan
derivatives,
which
were
subsequently
treated
with
4-methylbenzenethiol
trimethylamine
produce
thio-Michael
addition
products
in
high
excellent
yields
good
diastereoselectivities.
Chemical Communications,
Год журнала:
2022,
Номер
58(46), С. 6646 - 6649
Опубликована: Янв. 1, 2022
In
this
paper,
a
new
type
of
δ-vinylvalerolactone
was
designed
and
synthesized,
used
as
precursor
in
Pd-catalyzed
[6+3]
cycloaddition
with
azomethine
imines,
leading
to
nine-membered
1,2-dinitrogen-containing
heterocycles
77-98%
yields
>20
:
1
d.r.
These
ring-fused
products
were
further
transformed
into
unusual
tetracyclic
bridged-ring
compounds
without
loss
the
diastereoselectivities.
