Enantioselective construction of spiro-tetrahydroquinoline scaffolds through asymmetric catalytic cascade reactions DOI
Jialü Zhang, Rui Ma,

Huanhuan Zhao

и другие.

Chemical Communications, Год журнала: 2022, Номер 58(21), С. 3493 - 3496

Опубликована: Янв. 1, 2022

An efficient and concise strategy has been successfully developed for merging spiro-tetrahydroquinoline with spiro-benzofuranone into a single new skeleton through asymmetric catalytic cascade reactions catalyzed by quinine-derived chiral bifunctional squaramide organocatalysts. In this approach, differently substituted derivatives were smoothly obtained high yields, excellent diastereoselectivities enantioselectivities (up to 99% yield, up >20 : 1 dr, >99% ee, 40 examples) under mild reaction conditions.

Язык: Английский

Palladium-Catalyzed Asymmetric Cascade Intramolecular Cyclization/Intermolecular Michael Addition Reaction of Allenyl Benzoxazinones with 1-Azadienes DOI

Huawei Lin,

Xianru Yang,

Wenyue Ning

и другие.

Organic Letters, Год журнала: 2022, Номер 24(51), С. 9442 - 9446

Опубликована: Дек. 20, 2022

We herein designed and synthesized allenyl benzoxazinones of a novel type, which were then involved in Pd-catalyzed asymmetric cascade intramolecular cyclization/intermolecular Michael addition reaction with 1-azadienes. A broad range chiral C2-functionalized quinoline derivatives afforded moderate to good yields (up 93%) high enantioselectivities 93% ee) this reaction.

Язык: Английский

Процитировано

16
Atroposelective Synthesis of 1,1′‐Bipyrroles Bearing a Chiral N−N Axis: Chiral Phosphoric Acid Catalysis with Lewis Acid Induced Enantiodivergence DOI
Yaru Gao,

Luo‐Yu Wang,

Tao Zhang

и другие.

Angewandte Chemie, Год журнала: 2022, Номер 134(16)

Опубликована: Фев. 17, 2022

Abstract We present herein a highly efficient atroposelective synthesis of axially chiral 1,1′‐bipyrroles bearing an N−N linkage from simple hydrazine and 1,4‐diones. Further product derivatizations led to bifunctional compounds with high potential in asymmetric catalysis. For this chrial phosphoric acid (CPA)‐catalyzed double Paal–Knorr reaction, intriguing Fe(OTf) 3 ‐induced enantiodivergence was also observed.

Язык: Английский

Процитировано

15
Recent Advances in Palladium-Catalyzed [4 + n] Cycloaddition of Lactones, Benzoxazinanones, Allylic Carbonates, and Vinyloxetanes DOI
Mengyan Guo, Panke Zhang, Er‐Qing Li

и другие.

Topics in Current Chemistry, Год журнала: 2023, Номер 381(6)

Опубликована: Ноя. 3, 2023

Язык: Английский

Процитировано

9
Phosphine-catalyzed [3 + 2]-annulation of Morita–Baylis–Hillman carbonates with benzofuran-derived azadienes: Synthesis of spiro-cyclopentane benzofurans DOI

Wanxing Liu,

Yandong Lv,

Xiaohang Liu

и другие.

Tetrahedron, Год журнала: 2025, Номер 182, С. 134703 - 134703

Опубликована: Май 9, 2025

Язык: Английский

Процитировано

0
Enantioselective construction of spiro-tetrahydroquinoline scaffolds through asymmetric catalytic cascade reactions DOI
Jialü Zhang, Rui Ma,

Huanhuan Zhao

и другие.

Chemical Communications, Год журнала: 2022, Номер 58(21), С. 3493 - 3496

Опубликована: Янв. 1, 2022

An efficient and concise strategy has been successfully developed for merging spiro-tetrahydroquinoline with spiro-benzofuranone into a single new skeleton through asymmetric catalytic cascade reactions catalyzed by quinine-derived chiral bifunctional squaramide organocatalysts. In this approach, differently substituted derivatives were smoothly obtained high yields, excellent diastereoselectivities enantioselectivities (up to 99% yield, up >20 : 1 dr, >99% ee, 40 examples) under mild reaction conditions.

Язык: Английский

Процитировано

14