Scientia Sinica Chimica,
Год журнала:
2022,
Номер
53(2), С. 129 - 144
Опубликована: Окт. 20, 2022
Amides
compounds
have
a
wide
range
of
application,
and
many
transforming
strategies
been
reported.
Transition
metals-catalyzed
non-decarbonylative
cross-coupling
reaction
amides
has
gained
considerable
attention
due
to
low
cost,
high
efficiency,
good
compatibility
functional
groups.
The
reactions
following
disadvantages
the
inherent
nature
catalytic
system:
expensive
catalysts,
complex
ligands,
cocatalysts
trace
metals
residues.
transition-metal-free
amide
activation
for
synthesis
ketones
avoid
above
problems
with
efficiency
simple
treatment.
From
perspective
sustainable
development,
development
strategy
without
transition
great
significance.
In
this
paper,
by
C–N
bond
cleavage
were
reviewed.
main
contents
as
follows:
(1)
direct
addition
alkali
metal/alkaline-earth
metal
reagents
amides;
(2)
Brønsted
base-promoted
alkanes
activated
groups;
(3)
based
on
strategy;
(4)
acid-promoted
Friedel-Crafts
acylation
amide;
(5)
Lewis
between
alkyl
ketone.
This
review
provides
inspiration
subsequent
economic
green
reaction.
Asian Journal of Organic Chemistry,
Год журнала:
2022,
Номер
11(10)
Опубликована: Авг. 17, 2022
Abstract
A
wide
range
of
functionalized
N
‐Cbz
amides
underwent
base‐promoted
C−C
coupling
reactions
with
enolizable
esters,
ketones
and
to
afford
1,3‐dicarbonyl
compounds
under
mild
conditions.
The
proceeded
at
room
temperature
in
the
presence
LiHMDS
cyclopentyl
methyl
ether
(CPME).
desired
β‐ketoesters,
β‐keto
1,3‐diketones
were
obtained
good
excellent
yields
a
short
reaction
time.
Broad
substrate
scope,
functional
group
tolerance
metal‐free
conditions
are
merits
developed
methodology.
Chinese Journal of Organic Chemistry,
Год журнала:
2024,
Номер
44(4), С. 1293 - 1293
Опубликована: Янв. 1, 2024
A
metal-free
catalytic
system
for
the
esterification
reaction
of
N-benzyl-N-t-butoxycarbonyl-amides
with
unsaturated
alcohols
was
reported.With
assistance
amounts
lithium
tert-butoxide,
highly
reactive
N-t-butoxycarbonyl-amides
were
able
to
act
as
electrophiles
and
undergo
reactions
produce
a
series
esters
in
excellent
yields.Furthermore,
this
allowed
relatively
mild
conditions,
making
it
suitable
choice
late-stage
modification
natural
products
drug
molecules.
Scientia Sinica Chimica,
Год журнала:
2022,
Номер
53(2), С. 129 - 144
Опубликована: Окт. 20, 2022
Amides
compounds
have
a
wide
range
of
application,
and
many
transforming
strategies
been
reported.
Transition
metals-catalyzed
non-decarbonylative
cross-coupling
reaction
amides
has
gained
considerable
attention
due
to
low
cost,
high
efficiency,
good
compatibility
functional
groups.
The
reactions
following
disadvantages
the
inherent
nature
catalytic
system:
expensive
catalysts,
complex
ligands,
cocatalysts
trace
metals
residues.
transition-metal-free
amide
activation
for
synthesis
ketones
avoid
above
problems
with
efficiency
simple
treatment.
From
perspective
sustainable
development,
development
strategy
without
transition
great
significance.
In
this
paper,
by
C–N
bond
cleavage
were
reviewed.
main
contents
as
follows:
(1)
direct
addition
alkali
metal/alkaline-earth
metal
reagents
amides;
(2)
Brønsted
base-promoted
alkanes
activated
groups;
(3)
based
on
strategy;
(4)
acid-promoted
Friedel-Crafts
acylation
amide;
(5)
Lewis
between
alkyl
ketone.
This
review
provides
inspiration
subsequent
economic
green
reaction.
