Rhodium‐Catalyzed CH Functionalization to Construct Annulated Molecules DOI
Sujit Mahato, Writhabrata Sarkar, Koushik Naskar

и другие.

Handbook of CH‐Functionalization, Год журнала: 2022, Номер unknown, С. 1 - 39

Опубликована: Окт. 2, 2022

Abstract Rhodium complexes are exceptionally significant in homogeneous catalysis. The synthetic community observed the rapid burgeoning of such rhodium catalysis since discovery Wilkinson's catalyst. Rhodium‐catalyzed tandem C(sp 2 )H/C(sp 3 )H activation and annulation with alkenes, alkynes, arenes, other reactive partners is a rapidly growing research field to obtain new class heterocycles thereby generates potential biologically active pharmacophores. Superior reactivity catalysts attributed due its good π‐acceptor character that favors CH bond reaction substrates containing wide range directing groups, as amides, imines, carboxylic acid (derivatives), benzylic alcohols, ketones, various shown efficiency toward befitting partners; even undirected activations have also been achieved. This article provides brief account recent developments rhodium‐catalyzed activation/annulation reactions for synthesis classes fused cyclic scaffolds using suitable coupling partners. For strategies, different types cyclization reactions, namely, oxidative, redox‐neutral, photoredox, electrochemical discussed. In addition, enantioselective annulated molecules chiral has highlighted.

Язык: Английский

C–H activation: A sustainable approach for the synthesis of functionalized heterocycles DOI
Indu Sharma,

Mukesh Kumari,

Gargi Poonia

и другие.

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 115 - 138

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0
Silberfreie C−H‐Aktivierung: Strategische Ansätze zur Erschließung des vollen Potenzials von C−H‐Aktivierungen in der nachhaltigen organischen Synthese DOI Creative Commons
Arup Mondal, Manuel van Gemmeren

Angewandte Chemie, Год журнала: 2022, Номер 134(48)

Опубликована: Сен. 5, 2022

Abstract Die Aktivierung von C–H‐Bindungen gilt als eine der attraktivsten Methoden in organischen Synthesechemie, da sie das Potenzial hat, Synthesewege zu verkürzen und gegenüber herkömmlichen Synthesestrategien komplementäre Produktpalette erzeugen. Bei vielen aktuellen werden jedoch Silbersalze Additive eingesetzt, was stöchiometrischem Metallabfall führt so verhindert, dass volle C−H‐Aktivierung ausgeschöpft kann. Daher erhält die Entwicklung silberfreien Protokollen letzter Zeit immer mehr Aufmerksamkeit. Mechanistisch kann Silber bei verschiedene Funktionen erfüllen, sodass Vermeidung des Einsatzes unterschiedliche Ansätze erfordert, je nachdem, welche Funktion es einem bestimmten Prozess erfüllt. In diesem Aufsatz wird ein Vergleich silberbasierten ‐freien vorgestellt. Wir konzentrieren uns auf strategischen zur einer statten den Leser mit dem nötigen Grundwissen aus, um nachhaltige für entwickeln.

Процитировано

2
On the Brønsted acid-catalyzed aza-Michael reaction of isoxazol-5-ones to enones: reaction optimization, scope, mechanistic investigations and scale-up DOI

Marcelo Siqueira,

Pedro P. de Castro, Juliana Alves dos Santos

и другие.

Reaction Chemistry & Engineering, Год журнала: 2023, Номер 8(5), С. 1204 - 1215

Опубликована: Янв. 1, 2023

Regioselective aza-Michael-type of isoxazol-5-ones to activate double bonds.

Язык: Английский

Процитировано

0
Rhodium‐Catalyzed CH Functionalization to Construct Annulated Molecules DOI
Sujit Mahato, Writhabrata Sarkar, Koushik Naskar

и другие.

Handbook of CH‐Functionalization, Год журнала: 2022, Номер unknown, С. 1 - 39

Опубликована: Окт. 2, 2022

Abstract Rhodium complexes are exceptionally significant in homogeneous catalysis. The synthetic community observed the rapid burgeoning of such rhodium catalysis since discovery Wilkinson's catalyst. Rhodium‐catalyzed tandem C(sp 2 )H/C(sp 3 )H activation and annulation with alkenes, alkynes, arenes, other reactive partners is a rapidly growing research field to obtain new class heterocycles thereby generates potential biologically active pharmacophores. Superior reactivity catalysts attributed due its good π‐acceptor character that favors CH bond reaction substrates containing wide range directing groups, as amides, imines, carboxylic acid (derivatives), benzylic alcohols, ketones, various shown efficiency toward befitting partners; even undirected activations have also been achieved. This article provides brief account recent developments rhodium‐catalyzed activation/annulation reactions for synthesis classes fused cyclic scaffolds using suitable coupling partners. For strategies, different types cyclization reactions, namely, oxidative, redox‐neutral, photoredox, electrochemical discussed. In addition, enantioselective annulated molecules chiral has highlighted.

Язык: Английский

Процитировано

0