Research Progress in Synthesis and Application of Thiosulfonates

Chinese Journal of Organic Chemistry, Год журнала: 2022, Номер 42(8), С. 2322 - 2322

Опубликована: Янв. 1, 2022

As an important kind of synthons, thiosulfonates can react with alkynes, alkenes, aldehydes, and halogenated hydrocarbons to synthesize thioethers sulfones.At the same time, some thiosulfonate compounds have anti-viral anti-fungal bioactivities.The synthesis their applications in organic been under spotlight.Thus, according different types catalysts new progress green chemistry, is summarized.On other hand, reactants reaction types, application reviewed.In future, among researches on construction sulfides thiosulfonates, various difunctionalization reactions are still promising directions.

Язык: Английский

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Copper(I)-Catalyzed Three-Component Selenosulfonation of Maleimides with Sulfonyl Hydrazides and Diselenides via Radical Relay

The Journal of Organic Chemistry, Год журнала: 2022, Номер 87(22), С. 15661 - 15669

Опубликована: Ноя. 1, 2022

By employing Cu(CH3CN)4PF6 as the catalyst and tert-butyl hydroperoxide oxidant, we realized a three-component radical selenosulfonation of substituted maleimides, sulfonyl hydrazides, diphenyl diselenides, providing series 3,4-selenosulfonylated succinimides in moderate to good yields. This reaction features broad substrate scopes, high functional-group tolerability, feasibility gram-scale synthesis, enabling one-step construction C–SO2 C–Se bonds under mild conditions. Preliminary mechanistic studies support free-radical-induced pathway.

Язык: Английский

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Copper-catalyzed 1,2,2-trifunctionalization of maleimides with 1,7-enynes and oxime esters via radical relay/1,5-hydrogen-atom transfer

Organic Chemistry Frontiers, Год журнала: 2023, Номер 10(24), С. 6096 - 6102

Опубликована: Янв. 1, 2023

We describe a novel 1,2,2-trifunctionalization of maleimides with 1,7-enynes and oxime esters through simultaneous construction four C−C bonds C≡N bond in one pot based on the radical relay/1,5-hydrogen-atom transfer (HAT).

Язык: Английский

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Overcoming Radical Stability Order via DABCO-Triggered Desulfurization: Visible-Light-Promoted 1,2,4-Trifunctionalization of Butenyl Benzothiazole Sulfone with Thiosulfonate

The Journal of Organic Chemistry, Год журнала: 2023, Номер 89(1), С. 474 - 483

Опубликована: Дек. 14, 2023

A radical 1,2,4-trifunctional reaction of thiosulfonate to unactivated olefin is achieved by a migration strategy under mild conditions. In this reaction, the more unstable primary free radicals are in situ generated after heteroaryl groups presence DABCO. This trifunctionalization olefins involves two C–S bond formations and one C–C formation.

Язык: Английский

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Synthesis of Thiosulfonates through Aerobic Oxidation of Thiophenol under Metal-Free Conditions

Journal of Molecular Structure, Год журнала: 2024, Номер 1313, С. 138661 - 138661

Опубликована: Май 22, 2024

Язык: Английский

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