Organometallics,
Год журнала:
2022,
Номер
41(21), С. 2942 - 2948
Опубликована: Окт. 31, 2022
The
mechanism
and
reactivity
of
Ir-catalyzed
α-amidation
2-acylimidazoles
have
been
investigated
at
the
B3LYP-D3
level,
with
emphasis
on
nitrene
insertion
selectivity.
calculation
results
show
that
catalytic
consists
iridacycle
formation,
CO2
release,
insertion,
amido
protonation
processes.
Thereinto,
is
both
rate-
selectivity-determining
steps.
origin
group
favorably
inserting
into
an
Ir–Cα
over
Cγ–H
bond
was
further
unraveled.
In
addition,
this
work
also
explored
difference
between
α-mono-
α,α-di-substituted
source
identified.
These
meaningful
insights
may
serve
as
basis
for
design
development
transition-metal-catalyzed
systems
featuring
high
Organic Chemistry Frontiers,
Год журнала:
2022,
Номер
9(9), С. 2529 - 2533
Опубликована: Янв. 1, 2022
A
transition
metal-
and
oxidant-free
C–C/C–N
annulation
of
azomethine
imines
with
vinylene
carbonate
as
dual
synthons
under
simple
reaction
conditions
is
described
herein.
New Journal of Chemistry,
Год журнала:
2023,
Номер
47(19), С. 9401 - 9413
Опубликована: Янв. 1, 2023
A
proficient
copper(
i
)
catalyzed
one
pot
synthetic
protocol
has
been
established
to
synthesize
medicinally
essential
substituted
imidazo[1,2-
a
]pyridines
via
C–H
bond
amination
followed
by
acetylene
incorporation
under
microwave
irradiation.
Advanced Synthesis & Catalysis,
Год журнала:
2022,
Номер
364(17), С. 2911 - 2915
Опубликована: Июль 13, 2022
Abstract
We
report
here
a
mechanochemical
Cu‐catalyzed
[3+2]
cycloaddition
of
azinium‐
N
‐imines
with
nitriles
under
solventless
grinding
conditions.
Various
1,2,4‐triazolos
derivatives
were
obtained
in
51–80%
yields.
The
developed
protocol
offers
advantages
functional‐group
compatibility,
scalability,
no
use
solvents,
shorter
reaction
time,
and
without
external
heating.
In
addition,
heterocyclic
such
as
quinolinium
isoquinolinium
salts
are
also
suitable
substrates,
resulting
the
production
1,2,4‐triazolo[1,5‐
]quinoline
1,2,4‐triazolo[5,1‐
]isoquinoline
magnified
image
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(11), С. 7199 - 7207
Опубликована: Май 12, 2023
Pyridinium
1,4-zwitterionic
thiolates
were
regarded
as
powerful
and
versatile
building
blocks
to
prepare
nitrogen-
sulfur-containing
heterocycles.
Herein,
we
reported
a
copper-catalyzed
formal
[4
+
1]
annulation
of
pyridinium
diazo
compounds
without
any
additives
access
library
trifunctionalized
indolizines
in
good
yields.
Besides,
isoquinolinium
imidazolium
also
applied
this
reaction.
Of
particular
note
is
that
various
functional
groups
such
-CO2R,
-CO2NR2,
-CF3,
-CN,
-(O)P(OR)2
could
be
easily
introduced
into
cycloaddition
products
by
strategy.
Green Chemistry,
Год журнала:
2024,
Номер
26(6), С. 3522 - 3526
Опубликована: Янв. 1, 2024
A
novel
strategy
for
synthesizing
triazolinone
with
C
,
N
-cycloazomethylimine
and
dioxazolone
has
been
developed,
in
which
the
isocyanate
formed
situ
from
is
employed
cyclization
instead
of
widely
used
-acyl
nitrene.
Chemical Communications,
Год журнала:
2022,
Номер
58(98), С. 13644 - 13647
Опубликована: Янв. 1, 2022
This
paper
describes
iron/photoredox
dual-catalyzed
acyl
nitrene
formation
and
the
use
of
in
constructing
various
C-O
bonds
towards
phthalides.
The
developed
reaction
starts
from
N-methoxyl-2-alkylbenzamides.
Mechanism
surveys
suggest
involves
iron
nitrene-based
hydrogen
atom
abstraction
(HAA),
radical-polar
crossover
O-nucleophilic
SN1.
Distinctively,
often-reported
radical
rebound
previous
publications
is
not
observed.
represents
first
example
on
synthesis
Moreover,
it
also
serves
as
a
supplement
for
marketed
medicines
such
3-butylphthalides
(NBP),
thalidomide,
Pomalyst
Otezia.
Molecules,
Год журнала:
2024,
Номер
29(4), С. 894 - 894
Опубликована: Фев. 18, 2024
A
catalyst-free,
additive-free,
and
eco-friendly
method
for
synthesizing
1,2,4-triazolo[1,5-a]pyridines
under
microwave
conditions
has
been
established.
This
tandem
reaction
involves
the
use
of
enaminonitriles
benzohydrazides,
a
transamidation
mechanism
followed
by
nucleophilic
addition
with
nitrile,
subsequent
condensation
to
yield
target
compound
in
short
time.
The
methodology
demonstrates
broad
substrate
scope
good
functional
group
tolerance,
resulting
formation
products
good-to-excellent
yields.
Furthermore,
scale-up
late-stage
functionalization
triazolo
pyridine
further
demonstrate
its
synthetic
utility.
plausible
pathway,
based
on
our
findings,
proposed.
Organic Letters,
Год журнала:
2024,
Номер
26(45), С. 9648 - 9653
Опубликована: Ноя. 1, 2024
An
unprecedented
five-component
[2
+
2
1
1]
benzannulation
strategy
for
regioselective
assembly
of
densely
functionalized
aromatic
amines
from
two
ynals,
malononitriles,
and
sodium
sulfinates
is
established.
The
protocol
enables
the
efficient
installation
five
substituents
on
a
benzene
ring
via
formation
multiple
chemical
bonds
in
single
operation,
providing
various
multifunctionalized
primary
moderate
to
good
yields.
Additionally,
three-component
[3
cycloaddition
NH4SCN
was
also
achieved
produce
2-amnopyridine
derivatives
with
serving
as
an
ammonia
surrogate.
