Synthesis,
Год журнала:
2023,
Номер
55(10), С. 1593 - 1601
Опубликована: Янв. 12, 2023
Abstract
An
SbCl3-initiated
Csp3
–Csp3
coupling
between
N-aryltetrahydroisoquinolines
and
nitromethanes
was
realized
through
the
aerobic
oxidation
of
sp
3
C–H
bond,
providing
a
series
nitromethylated
tetrahydroisoquinoline
derivatives
in
high
yields.
The
results
exhibited
that
SbCl3,
as
cheap
commercially
available
reagent,
is
an
efficient
initiator
to
promote
direct
functionalization
sp3
bond
with
broad
functional
group
tolerance,
which
potentially
applied
wider
range
activation
reactions.
Chem,
Год журнала:
2024,
Номер
10(4), С. 1240 - 1251
Опубликована: Фев. 13, 2024
The
photoactivation
of
sulfonium
salt
EDA
(electron
donor-acceptor)
complexes
provides
a
mild
platform
for
aryl-radical-mediated
halogen
atom
transfer
activation
wide
range
functionalized
alkyl
iodides,
including
tertiary
iodides.
Using
an
aryl
with
carbonate
as
inexpensive
donor
complex
formation,
the
general
reaction
has
been
applied
in
divergent,
metal-free
photochemical
approach
to
nitriles
and
amides.
This
divergency
was
made
possible
by
tuning
isocyanide
radical
traps.
For
example,
identification
readily
accessible,
bench-stable,
crystalline
amide
containing
grants
access
nitrile
products
complete
selectivity.
Organic Letters,
Год журнала:
2022,
Номер
24(28), С. 5105 - 5108
Опубликована: Июль 13, 2022
The
development
of
sustainable
C(sp3)–H
functionalization
methods
is
great
interest
to
the
pharmaceutical
and
agrochemical
industries.
Anodic
oxidation
an
efficient
means
producing
benzylic
cations
that
can
undergo
subsequent
in
situ
nucleophilic
attack
afford
functionalized
products.
Herein,
we
demonstrate
suitability
carboxylic
acids
as
nucleophiles
yield
esters.
This
method
employs
a
series
secondary
substrates
demonstrated
on
gram
scale
flow.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(17), С. 12311 - 12318
Опубликована: Авг. 16, 2023
Dithiocarbamates
synthesis
is
extremely
important
in
plenty
of
biomedical
and
agrochemical
applications,
especially
fungicide
development,
but
remains
a
great
challenge.
In
this
work,
we
have
successfully
developed
multicomponent
reaction
protocol
to
convert
H2S
into
S-alkyl
dithiocarbamates
under
constant
current
conditions.
No
additional
oxidants
nor
catalysts
are
required,
due
mild
conditions,
the
reactions
display
broad
substrate
scope,
including
varieties
thiols
or
disulfides.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 30, 2024
With
the
assistance
of
nickel
as
catalyst,
2,2'-bipyridine
(bpy)
ligand,
and
manganese
reducing
metal,
reductive
amidation
isocyanates
with
readily
accessible
aryl
fluorosulfates
could
be
successfully
accomplished.
The
reactions
proceeded
effectively
via
C-O
bond
activation
in
DMF
at
room
temperature,
enabling
facile
synthesis
a
range
structurally
diverse
amides
moderate
to
high
yields
broad
functionality
compatibility.
In
addition,
synthetic
usefulness
method
was
further
demonstrated
by
applying
reaction
scale-up
late-stage
functionalization
complex
molecules
biological
activities.
The Chemical Record,
Год журнала:
2022,
Номер
23(1)
Опубликована: Сен. 20, 2022
Abstract
Isocyanides
are
well‐known
as
efficient
CO
surrogates
and
C1
synthons
in
modern
organic
synthesis.
Although
tremendous
efforts
have
been
devoted
to
fully
exploiting
the
reactivity
of
isocyanides,
these
transformations
primarily
limited
by
their
utilization
stoichiometric
toxic
chemical
oxidants.
With
recent
resurgence
electrochemistry,
which
has
considerably
laid
dormant
over
past
several
decades,
electrolysis
identified
a
green
powerful
tool
enrich
structural
diversity
solely
utilizing
electric
current
clean
inherently
safe
redox
equivalents
In
this
regard,
unique
isocyanides
studied
numerous
electrochemical
transformations.
This
review
comprehensively
highlights
most
relevant
progress
strategies
towards
functionalization
up
until
June
2022,
with
focus
on
reaction
outcomes
mechanisms.
Organic Chemistry Frontiers,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Reported
herein
is
a
transition
metal
catalyst-
and
oxidant-free
platform
for
diversity-oriented
benzylic
C–H
functionalization.
The
process
involves
electrochemical
C(sp
3
)–H
oxygenation
followed
by
elimination/substitution
with
diverse
nucleophiles.
