Abstract
Over
the
last
three
decades,
owing
to
labour
cost,
time
and
especially
environmental
issues,
one‐pot
synthesis
of
heterocyclic
compounds
involving
tandem
or
multicomponent
(sequential
consecutive)
reactions
has
gained
particular
attention
worldwide.
Most
marketed
drug
molecules
hold
one
more
rings.
Due
some
side
effects
several
drugs
along
with
gradual
emergence
antimicrobial
resistance,
necessity
for
developing
new
continues;
special
should
be
paid
in
this
respect
towards
employing
their
syntheses.
Pyrazolopyridines
are
fused
heterocycles
holding
pyridine
pyrazole
possess
a
wide
variety
biological
pharmaceutical
properties.
Several
existing
also
bear
pyrazolopyridine
scaffolds.
The
present
perspective
is
an
endeavour
encompass
green
syntheses
different
isomeric
systems,
most
these
published
during
past
five
years
few
cases.
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(22), С. 5717 - 5734
Опубликована: Янв. 1, 2023
Vinylene
carbonate
(VC)
has
emerged
as
a
promising
coupling
partner
to
participate
in
various
attractive
C–H
conversions
and
implement
an
increasing
number
of
novel
reactions.
In
this
review,
we
provide
summary
the
advancements
achieved
metal-catalyzed
functionalization
using
VC.
Advanced Synthesis & Catalysis,
Год журнала:
2023,
Номер
365(9), С. 1457 - 1464
Опубликована: Апрель 14, 2023
Abstract
In
this
study,
Rh(III)‐catalyzed
C−H
bifunctionalization
and
direct
vinylene
annulation
of
sulfoxonium
ylides
N
‐carbamoylindoles
with
carbonate
was
accomplished,
which
afforded
a
series
naphthalenones
containing
β‐ketosulfoxonium
ylide
moiety,
isocoumarins,
pyrimidones.
This
protocol
featured
mild
conditions,
broad
substrate
scope,
functional‐groups
compatibility.
addition,
related
applications
preliminary
mechanistic
exploratory
were
also
investigated
magnified
image
Green Chemistry,
Год журнала:
2023,
Номер
25(11), С. 4282 - 4291
Опубликована: Янв. 1, 2023
The
chemical
upcycling
of
poly(bisphenol
A
carbonate)
was
carried
out
through
organocatalysis
using
α-hydroxyketones
as
nucleophiles,
leading
to
valuable
vinylene
carbonates.
Advanced Synthesis & Catalysis,
Год журнала:
2023,
Номер
365(20), С. 3400 - 3412
Опубликована: Сен. 6, 2023
Abstract
Recently,
vinylene
carbonate
has
been
developed
as
a
powerful
synthon
in
transition
metal‐catalyzed
C−H
bond
activation/cyclization
reactions.
This
review
introduces
recent
progress
the
use
of
reactant,
by
analyzing
and
comparing
reaction
models
involving
surrogate
ethynol,
acetylene,
acetylation
reagents
or
other
reactants,
while
addressing
related
mechanisms
synthetic
applications.
Chemical Communications,
Год журнала:
2024,
Номер
60(26), С. 3571 - 3574
Опубликована: Янв. 1, 2024
Herein,
a
novel
Pd-catalyzed
denitrogenation/vinylation
of
benzotriazinones
using
vinylene
carbonate
as
the
vinylation
reagent
is
reported.
This
transformation
demonstrates
an
unprecedented
skeletal
editing
approach,
effectively
converting
NN
to
CC
fragments
Organic & Biomolecular Chemistry,
Год журнала:
2022,
Номер
20(48), С. 9604 - 9608
Опубликована: Янв. 1, 2022
An
efficient
metal-free
annulative
vinylene
transfer
protocol
for
the
synthesis
of
benzo-fused
indolizines
via
1,3-dipolar
cycloadditions
N-ylides
with
carbonate
has
been
developed.
Vinylene
serves
as
an
acetylene
surrogate
without
any
external
oxidant
involved.
This
transformation
leads
to
direct
construction
versatile
indolizine
derivatives
in
moderate
good
yields.
Organic Letters,
Год журнала:
2022,
Номер
24(41), С. 7502 - 7506
Опубликована: Окт. 11, 2022
A
highly
regioselective
synthesis
of
spiro[benzofuran-2,2'-furan]-3-ones
has
been
explored
via
Lewis
acid-catalyzed
[3
+
2]
cyclization
iodonium
ylides
with
azadienes.
The
acidity
the
acid
was
significantly
strengthened
strong
hydrogen
bond
donors,
thereby
promoting
enolization
isomerization
for
subsequent
cycloaddition.
This
reaction
compatible
a
broad
range
substrates
under
mild
conditions,
and
efficiently
delivered
spiro-heterocycles
excellent
stereoselectivity.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 3, 2025
A
divergent
[5
+
1]
cyclization
reaction
of
o-aminobenzamides
with
vinylene
carbonate
has
been
developed,
rapidly
generating
three
types
cyclic
molecules
including
quinazolinones,
2-methylquinazolinones,
and
2,3-dihydroquinazolinones
high
chemoselectivity.
In
this
discovery,
blooms
as
a
multifunctional
reagent
to
participate
in
cyclization.
The
potential
new
finding
is
further
emphasized
by
assembling
the
benzothiazole
heteroarene
via
[4
version
tolerating
bioactive
units
well.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 18, 2025
A
Pd-catalyzed
protocol
that
provides
efficient
access
to
acyclic
1,2-dioxygenated
dienes
has
been
established.
The
installation
of
the
bifunctional
carbonate
electrofuge
diene
cores
enabled
such
undergo
a
regioselective
decarboxylative
Diels-Alder
cycloaddition/aromatization
reaction,
affording
diverse
synthetic
challenging
multisubstituted
phenols
with
ease.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(5), С. 3238 - 3250
Опубликована: Фев. 14, 2024
A
Co(III)-catalyzed
vinylene
transfer
reaction
enabled
by
carboxylic
acid
is
presented.
This
redox-neutral
transformation
tolerates
various
functional
groups,
including
free
hydroxyl
and
features
practicality.
Five-step
routes
based
on
the
Heck
annulation
have
been
devised
to
total
synthesis
of
8-oxodehydrodiscretamine
2-demethyl-oxypalmatine
without
protection
functionality.
