A
method
was
found
to
construct
sulfur-containing
five-
and
six-membered
heterocyclic
alkyl
sulfonyl
compounds
by
using
visible
light
free
radicals
activated
and/or
generated
EDA
complexes/homolytic
cleavage
as
initiators
stimulate
the
relay
reaction
of
alkynes/alkynones.
This
puts
forward
a
new
strategy
initiate
sulfonation
alkynes/alkynones
with
only
catalytic
amount
initiator.
generating
initiator
complex
activation/homolytic
provides
idea
for
following
substances
that
must
be
excited.
Organic & Biomolecular Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
highlights
the
recent
advances
in
multi-component
reactions
for
synthesizing
heterocyclic
compounds
via
green
approaches
including
photoredox
catalysis,
electrochemical
activation,
catalyst-free
methods
and
use
of
water
as
sole
solvent.
Organic Letters,
Год журнала:
2022,
Номер
24(25), С. 4704 - 4709
Опубликована: Июнь 20, 2022
A
novel
visible-light-catalyzed
tandem
radical
addition/1,5-hydrogen
atom
transfer/cyclization
cascade
of
2-alkynylarylethers
with
sulfonyl
chlorides
in
2-methyltetrahydrofuran
was
developed
under
photocatalyst-
and
additive-free
conditions.
This
reaction
relies
on
unique
energy
transfer
solvent-radical
relay
strategies
to
generate
radicals
for
the
preparation
a
series
sulfonyl-functionalized
dihydrobenzofurans
moderate
high
yields
catalyzed
by
visible
light
or
solar
radiation.
Green Chemistry,
Год журнала:
2024,
Номер
26(6), С. 3301 - 3307
Опубликована: Янв. 1, 2024
An
efficient
multicomponent
reaction
for
the
preparation
of
vinyl
sulfone
was
achieved
by
hydrogenation/bifunctional
sulfonylation
alkynyl
esters
with
N-
allyl
bromodifluoroacetamide,
DABSO,
and
H
2
O
under
visible-light-only
conditions.
Organic Letters,
Год журнала:
2024,
Номер
26(18), С. 3810 - 3815
Опубликована: Апрель 28, 2024
A
visible-light-driven
photocatalytic
protocol
is
established
for
the
diastereoselective
synthesis
of
pyrrolo[3,2,1-jk]carbazoles
via
a
radical-triggered
multicomponent
bicyclization
reaction
starting
from
readily
available
indole-tethered
1,6-enynes
and
α-benzyl-α-bromomalonates
under
mild
conditions.
This
approach
exhibits
wide
substrate
compatibility
excellent
tolerability
toward
various
functional
groups
boasts
benefit
efficient
ring
formation
chemical
bond
creation.
Chemistry - A European Journal,
Год журнала:
2024,
Номер
30(43)
Опубликована: Июнь 4, 2024
Vinyl
sulfones
are
crucial
building
blocks
in
synthetic
chemistry
and
core
structural
units
of
pharmaceutically
active
molecules,
thus
extensive
investigations
have
been
conducted
on
the
construction
these
skeletons.
In
contrast
to
classical
approaches,
radical
sulfonylation
alkynes
for
producing
vinyl
has
garnered
considerable
interest
because
its
mild
conditions
high
efficiency.
Radical
sulfonation
typically
begins
with
sulfonyl
attacking
alkynes,
followed
by
further
functionalization.
Moreover,
association
metal-catalyst-free
systems
multicomponent
reactions
(MCRs)
offers
an
environmentally
friendly
pathway
efficiently
constructing
complex
scaffolds
from
readily
available
partners.
However,
there
is
no
comprehensive
review
summarizing
advancements
alkynes.
Hence,
we
provide
a
categorical
overview
based
objects
(hydrosulfonylation,
carbosulfonylation,
aminosulfonylation,
oxysulfonylation,
sulfosulfonylation,
selenosulfonylation,
iodosulfonylation),
along
interpretations
reaction
mechanisms.
Chemistry - An Asian Journal,
Год журнала:
2024,
Номер
19(14)
Опубликована: Май 8, 2024
The
beginning
of
photochemical
reactions
revolutionized
synthetic
chemistry
through
sustainable
practices.
This
review
explores
cutting-edge
developments
in
leveraging
light-induced
processes
for
generating
cascaded
C-C
and
C-hetero
bonds
without
catalysts.
Significantly,
catalyst-free
photoinduced
methodologies
have
garnered
considerable
attention,
especially
the
creation
varied
heterocyclic
frameworks
drug
design
synthesis
natural
products.
article
delves
into
underlying
mechanisms,
addresses
limitations,
evaluates
various
methodologies,
emphasizing
potential
photocatalyst
transition
metal-free
to
enhance
sustainability.
Divided
two
sections,
it
covers
recent
strides
C-heteroatom
multiple
bond
formation
reactions.
European Journal of Organic Chemistry,
Год журнала:
2023,
Номер
unknown
Опубликована: Авг. 31, 2023
Abstract
Achieving
high
molecular
complexity
can
be
not
trivial,
but
the
exploitation
of
domino
reactions
provides
an
atom‐
and
step‐economical
method
to
reach
this
target.
Over
past
decades,
a
lot
efforts
have
been
put
on
development
photocatalytic
cascades
employing
both
metal‐based
purely
organic
catalysts.
Despite
effectiveness
these
protocols,
catalyst‐
additive‐free
light‐induced
are
gaining
momentum
thank
their
efficiency,
operational
simplicity
sustainability.
The
increasing
number
papers
published
field
in
last
years
is
proof
appeal
transformations.
In
Review,
we
discuss
multicomponent
mediated
by
light
with
focus
photocatalyst‐
processes.
most
recent
advances
synthesis
complex
nitrogen‐,
oxygen‐,
sulphur‐
selenium‐heterocycles
together
analysed
emphasis
experimental
mechanistic
studies.
We
herein
present
a
green
and
mild
photoredox
strategy
for
constructing
framework
of
benzannulated
6,5-spiroketal
glycosides.
This
method
employs
various
O-arylacetylene
glycosides
aryl
ketone
acids
as
the
starting
materials,
facilitating
rapid
straightforward
synthesis
with
up
to
92%
yields
under
catalytic
conditions.
efficient
approach
has
potential
significantly
enhance
molecular
library
carbohydrate-based
pharmaceuticals.
Advanced Synthesis & Catalysis,
Год журнала:
2022,
Номер
364(23), С. 4020 - 4025
Опубликована: Окт. 21, 2022
Abstract
A
copper‐catalyzed
multicomponent
oxysulfonylation
of
alkenes
with
cyclobutanone
oxime
esters
and
hydroxamic
acids
via
the
insertion
sulfur
dioxide
has
been
developed.
This
reaction
uses
K
2
S
O
5
as
surrogate
in
situ
generated
amidoxyl
radical
interceptor,
thus
providing
a
direct
approach
to
β‐amidoxy
sulfones
35–90%
yields.
Mechanistic
studies
revealed
that
radical‐radical
coupling
alkyl
might
be
involved
this
transformation.
magnified
image
