Iron-catalyzed oxosulfonylation of alkynes with small-ring compounds and Na2S2O5 for the synthesis of β-keto sulfones DOI

Liu-Bin Li,

Hui Qiu,

Mu-Han Li

и другие.

Organic Chemistry Frontiers, Год журнала: 2023, Номер 10(20), С. 5190 - 5197

Опубликована: Янв. 1, 2023

An efficient and rapid iron-catalyzed oxosulfonylation of alkynes with small-ring compounds Na 2 S O 5 for the synthesis β -keto sulfones has been developed.

Язык: Английский

Generation of Sulfamoyl Radical for the Modular Synthesis of Sulfonamides DOI

Haiping Lv,

Xinzhou Chen, Xuemei Zhang

и другие.

ACS Catalysis, Год журнала: 2024, Номер 14(9), С. 6513 - 6524

Опубликована: Апрель 13, 2024

Efficient synthesis of sulfonamides has long been pursued by chemists due to their frequent occurrence in pharmaceuticals, especially anti-inflammatory medicines. The traditional assembly from sulfonyl chlorides and amines, as well the recently developed one-step involving sulfur dioxide, still faces challenges such poor substrate compatibility and/or stringent reaction conditions. Herein, we present a strategy for situ generation sulfamoyl radicals modular both alkenyl alkyl with wide applicability (>100 examples), mild conditions, easily accessible starting materials. This method is successfully applied late-stage modification drug molecules (23 molecule naratriptan, 15N-labeling sulfonamides.

Язык: Английский

Процитировано

6
Photoinduced Regioselective Fluorination and Vinylation of Remote C(sp3)–H Bonds Using Thianthrenium Salts DOI

Mengqi Luo,

Shibo Zhu,

Chao Yang

и другие.

Organic Letters, Год журнала: 2024, Номер 26(20), С. 4388 - 4393

Опубликована: Май 16, 2024

Herein, a photoredox-driven practical protocol for fluorinated alkene synthesis using easily accessible and modular thianthrenium salts with electron-withdrawing alkynes or propargyl alcohols is reported. Vinyl radical intermediates, formed by the reaction between alkyl trifluoromethyl electronically diverse alkynes, can mediate key 1,5-HAT process of regioselective C(sp3)–H fluorination vinylation. This provides straightforward access to structurally trifluoromethyl- distally fluoro-functionalized products in 21–79% yields broad substrate range under mild photocatalytic conditions.

Язык: Английский

Процитировано

6
Photoredox-catalyzed intermolecular azidosulfonylation of alkenes with DABCO·(SO2)2, trimethylsilyl azide and thianthrenium salts DOI

Huiling Ma,

Yanzhi Li, Peiqi Wang

и другие.

Organic Chemistry Frontiers, Год журнала: 2022, Номер 10(4), С. 866 - 871

Опубликована: Дек. 21, 2022

Synthesis of β-azido alkylsulfones through a photoredox-catalyzed azido sulfonylation alkenes with DABCO·(SO 2 ) , trimethylsilyl azide and alkyl thianthrenium salts is developed.

Язык: Английский

Процитировано

22
Recent advances in visible light mediated photoinduced aryl radical generation and its application in synthesis DOI Creative Commons
Tubai Ghosh, Sougata Santra, Grigory V. Zyryanov

и другие.

Journal of Photochemistry and Photobiology, Год журнала: 2023, Номер 16, С. 100192 - 100192

Опубликована: Июнь 16, 2023

The reactions involving aryl radicals is an efficient strategy for the synthesis of a wide variety important molecules. We have highlighted here recent developments on generation from various substrates by visible light mediated photocatalysis and their with different to produce library arylated het-arylated compounds. These are performed at room temperature using LED bulbs. Thus, this green less energy.

Язык: Английский

Процитировано

12
Iron-catalyzed oxosulfonylation of alkynes with small-ring compounds and Na2S2O5 for the synthesis of β-keto sulfones DOI

Liu-Bin Li,

Hui Qiu,

Mu-Han Li

и другие.

Organic Chemistry Frontiers, Год журнала: 2023, Номер 10(20), С. 5190 - 5197

Опубликована: Янв. 1, 2023

An efficient and rapid iron-catalyzed oxosulfonylation of alkynes with small-ring compounds Na 2 S O 5 for the synthesis β -keto sulfones has been developed.

Язык: Английский

Процитировано

12