Rongalite as a Versatile Reagent in Organic Synthesis^†

Chinese Journal of Chemistry, Год журнала: 2023, Номер 41(23), С. 3388 - 3400

Опубликована: Июнь 24, 2023

Comprehensive Summary This review provides a comprehensive summary of progress to date in the utilization rongalite as versatile reagent organic synthesis, with focus on recent researches. The contents have been organized according functions exhibited by rongalite. Reaction mechanisms are provided, demonstrating multifaceted roles this compound various transformations, including sulfone, C1 or masked proton source and single electron donor reducing agent.

Язык: Английский

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Recent advances in the synthesis and transformations of sulfinate esters

Chemical Communications, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Recent sulfinate esters chemistry is summarized in this feature article. Efficient methods to synthesize diverse from readily available starting materials and various modern transformations of are introduced.

Язык: Английский

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Research Progress on Sultine

Acta Chimica Sinica, Год журнала: 2024, Номер 82(2), С. 171 - 171

Опубликована: Янв. 1, 2024

Язык: Английский

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Sultines as o-Quinodimethane Precursors in an Oxa-Diels–Alder Reaction: Synthesis of Functionalized Isochromans

Synlett, Год журнала: 2024, Номер 35(10), С. 1180 - 1184

Опубликована: Янв. 2, 2024

Abstract The development of an oxa-Diels–Alder reaction between sultines and carbonyl compounds is reported. o-Quinodimethanes, generated from sultines, undergo a [4+2]-cycloaddition with activated aldehydes or ketones in the presence Cu(OTf)2 to provide variety functionalized isochromans, including spiroisochromans, up 99% yield. developed protocol demonstrates broad functional-group compatibility tolerates unprotected isatins bearing free NH-functionalities.

Язык: Английский

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Transition‐Metal Catalyzed [4+2]‐Cycloaddition Reactions: A Sexennial Update

ChemistrySelect, Год журнала: 2024, Номер 9(12)

Опубликована: Март 21, 2024

Abstract Cycloaddition reactions serve as exceptionally useful strategy to provide atom‐economical, efficient and practical access complex molecules from simple starting materials. The [4+2]‐cycloaddition reaction allows for the stereospecific construction of six‐membered carbo‐/heterocycles. catalyzed by transition metals are potent methods rapid highly functionalized molecular frameworks. This review article summarizes different reports on transition‐metal involving various such Pd, Cu, Rh, Au, Fe, Ni, Sc, Sn, Hf, Ag, Mn, Dy, Co etc. straightforward pharmaceutically active heterocycles. An emphasis is laid mechanistic insights highlight unique application novel processes transition‐metals in these transformations build intricate polycyclic structures.

Язык: Английский

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In(OTf)₃-catalyzed reorganization/cycloaddition of two imine units and subsequent modular assembly of acridinium photocatalysts

Chemical Science, Год журнала: 2023, Номер 14(19), С. 5160 - 5166

Опубликована: Янв. 1, 2023

Herein, we disclose a novel reorganization/cycloaddition between two imine units catalyzed by In(OTf) 3 Lewis acid that differs from the well-known [4 + 2] cycloaddition version via Povarov reaction.

Язык: Английский

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Three‐Component Aza‐Diels‐Alder Reaction for the Syntheses of Tetrahydroisoquinoline Derivatives

Asian Journal of Organic Chemistry, Год журнала: 2023, Номер 12(9)

Опубликована: Авг. 4, 2023

Abstract Reported herein is the development of a normal electron‐demand, three‐component aza‐Diels‐Alder reaction between sultines, aldehydes, and amines. In presence Cu(OTf) 2 as Lewis acid catalyst, use sultines o ‐quinodimethane precursors in conjunction with situ generation imines enables facile preparation various polysubstituted tetrahydro‐isoquinoline derivatives from readily available substrates. The synthetic utility these products was further explored through number product transformations, including syntheses tricyclic N ‐heterocycles.

Язык: Английский

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Aza-[4 + 2] annulations of α-vinyl Morita–Baylis–Hillman adducts for regiodivergent synthesis of exomethylene-bearing azatricyclic compounds

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(12), С. 3415 - 3420

Опубликована: Янв. 1, 2024

The regiodivergent synthesis of exomethylene-bearing azatricyclic products was achieved via aza-[4 + 2] annulations cyclic imines with a single C4 synthon, the α-vinyl MBH adduct.

Язык: Английский

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Three-component diels-alder reaction through palladium carbene migratory insertion enabled dearomative C(sp3)-H bond activation

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Дек. 30, 2024

Owning to the versatile nature in participation of Diels-Alder (D-A) reactions, development efficient approaches generate active ortho-quinodimethanes (o-QDMs) has gained much attention. However, a catalytic method involving coupling two readily accessible components construct o-QDMs is lacking. Herein, we describe palladium carbene migratory insertion enabled dearomative C(sp

Язык: Английский

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Six-membered ring systems: pyridines and benzo derivatives

Progress in heterocyclic chemistry, Год журнала: 2023, Номер unknown, С. 383 - 425

Опубликована: Янв. 1, 2023

Язык: Английский

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