A facile route for highly enantioenriched six‐membered 1,4‐N,N‐ and N,O‐heterocycles from L‐serinate‐derived α‐bromoacetates DOI
So Jeong Lee,

Min Ji Park,

Seyeon Kim

и другие.

Bulletin of the Korean Chemical Society, Год журнала: 2023, Номер 44(12), С. 1025 - 1033

Опубликована: Окт. 14, 2023

Abstract Preparation of highly enantioenriched six‐membered 1,4‐ N,N‐ and N,O‐ heterocycles has been developed through [4 + 2] heteroannulation α‐bromoacetates with 1,4‐binucleophiles. Two consecutive substitutions diastereoenriched L‐serinate‐derived provide convenient access to a wide range C‐aryl/aliphatic substituted up 99:1 er.

Язык: Английский

Access to enantioenriched dihydroquinoxalinones via Cu-catalyzed propargylic substitution DOI
Yuxi Zhang, Shu Xiao, Wusheng Guo

и другие.

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(7), С. 1996 - 2001

Опубликована: Янв. 1, 2024

A Cu-catalyzed straightforward approach for the synthesis of otherwise synthetically challenging enantioenriched dihydroquinoxalinones from propargylic esters and commercially readily available o -phenylenediamines is developed.

Язык: Английский

Процитировано

0
Facile access to C-substituted piperazin-2-ones and mianserin derivative enabled by chemoselective carbene insertion and cyclization cascade DOI

Dharmendra Kumar,

Urmila Unnikrishnan,

Malleswara Rao Kuram

и другие.

Chemical Communications, Год журнала: 2024, Номер 60(44), С. 5691 - 5694

Опубликована: Янв. 1, 2024

A simple method to synthesize carbon-substituted piperazinones achieved from donor–acceptor diazo compounds and 1,2-diamine derivatives under Cu-catalyzed conditions.

Язык: Английский

Процитировано

0
Ketone Scope and Their Limitations in Transition Metal Catalyzed Direct Asymmetric Hydrogenative Aminations DOI
S. Dharani, Muhammad Kamran, Xinyu Ma

и другие.

ChemistrySelect, Год журнала: 2024, Номер 9(26)

Опубликована: Июль 10, 2024

Abstract Chiral amines are valuable building blocks in the manufacture of agrochemicals, pharmaceuticals, natural products, fine chemicals, functional materials among others. Compared to asymmetric hydrogenation imines/enamides and biocatalytic/organocatalytic reductive amination, transition metal catalyzed direct hydrogenative amination reactions (DAHA) using molecular dihydrogen as reductant highly economical, atom and/or step‐efficient thus attractive for researchers from both industry academia. In previous reviews, catalysts/methods development, applications synthesis pharmaceuticals [N] source were summarized discussed. this review, we summarize discuss ketone substrates scope upon utilizing state‐of‐the‐art catalysts. The substrate limitations, potential key mechanisms also critically concluded.

Язык: Английский

Процитировано

0
Development of spirocyclic phosphoramidite-based hybrid diphosphorus ligands for enantioselective iridium-catalyzed hydrogenation of imines DOI

Long-Fei Nan,

Xiu-Shuai Chen,

Hao Chen

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2022, Номер 20(43), С. 8420 - 8424

Опубликована: Янв. 1, 2022

Unsymmetrical hybrid chiral diphosphorus ligands bearing a spirocyclic phosphoramidite scaffold have been developed and successfully applied in the iridium-catalyzed asymmetric hydrogenation of imines. With this newly iridium catalytic system, wide range imines including sterically hindered ones could be hydrogenated to give corresponding optically active amines high yields (up >99%) with excellent enantioselectivities >99% ee). The utility has demonstrated by preparation fungicide (S)-benalaxyl.

Язык: Английский

Процитировано

1
A facile route for highly enantioenriched six‐membered 1,4‐N,N‐ and N,O‐heterocycles from L‐serinate‐derived α‐bromoacetates DOI
So Jeong Lee,

Min Ji Park,

Seyeon Kim

и другие.

Bulletin of the Korean Chemical Society, Год журнала: 2023, Номер 44(12), С. 1025 - 1033

Опубликована: Окт. 14, 2023

Abstract Preparation of highly enantioenriched six‐membered 1,4‐ N,N‐ and N,O‐ heterocycles has been developed through [4 + 2] heteroannulation α‐bromoacetates with 1,4‐binucleophiles. Two consecutive substitutions diastereoenriched L‐serinate‐derived provide convenient access to a wide range C‐aryl/aliphatic substituted up 99:1 er.

Язык: Английский

Процитировано

0